Vacuolar H+-ATPase expression is increased in acid-secreting intercalated cells in kidneys of rats with hypercalcaemia-induced alkalosis

Acta Physiologica

Volumn 189, Issue 4, 2007, Pages 359-368

  Wang, W ^a   Praetorius, J ^a   Li, C ^a,b   Praetorius, H A ^a   Kwon, T H ^a,c   Frokiaer J ^a,b   Nielsen, S ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c Kyungpook National University School of Medicine   (South Korea)

Author keywords

Anion exchanger AE2; Electroneutral NBCn1; H+ ATPase; Kidney; Metabolic alkalosis

Indexed keywords

BICARBONATE; CALCIUM; COTRANSPORTER; PARATHYROID HORMONE; PROTON; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE;

ACID SECRETION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANION EXCHANGE; ARTICLE; CONTROLLED STUDY; HYPERCALCEMIA; IMMUNOHISTOCHEMISTRY; KIDNEY; KIDNEY MEDULLA; MALE; METABOLIC ALKALOSIS; NONHUMAN; OSMOTIC MINIPUMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RAT STRAIN; STATISTICAL SIGNIFICANCE; URINARY EXCRETION;

ALKALOSIS; ANIMALS; ANION EXCHANGE PROTEIN 1, ERYTHROCYTE; ANION TRANSPORT PROTEINS; ANTIPORTERS; CHLORIDE-BICARBONATE ANTIPORTERS; HYPERCALCEMIA; IMMUNOHISTOCHEMISTRY; INFUSIONS, PARENTERAL; KIDNEY; KIDNEY CORTEX; KIDNEY MEDULLA; MALE; PARATHYROID HORMONE; PROTON-TRANSLOCATING ATPASES; RATS; RATS, WISTAR; SODIUM-BICARBONATE SYMPORTERS; VACUOLES;

EID: 33947200585     PISSN: 17481708     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1748-1716.2007.01672.x     Document Type: Article

References (33)

1. Alper, S.L., Natale, J., Gluck, S., Lodish, H.F. & Brown, D. 1989. Subtypes of intercalated cells in rat kidney collecting duct defined by antibodies against erythroid band 3 and renal vacuolar H+-ATPase. Proc Natl Acad Sci USA 86, 5429-5433.
2. Alper, S.L., Stuart-Tilley, A.K., Biemesderfer, D., Shmukler, B.E. & Brown, D. 1997. Immunolocalization of AE2 anion exchanger in rat kidney. Am J Physiol 273, F601-F614.
3. Arruda, J.A. & Kurtzman, N.A. 1980. Hyperparathyroidism and metabolic acidosis: a complex interaction of multiple factors. Nephron 26, 1-6.
4. Arruda, J.A., Nascimento, L., Westenfelder, C. & Kurtzman, N.A. 1977. Effect of parathyroid hormone on urinary acidification. Am J Physiol 232, F429-F433.
5. Bank, N. & Aynediian, H.S. 1976. A micropuncture study of the effect of parathyroid hormone on renal bicarbonate reabsorption. J Clin Invest 58, 336-344.
6. Bengele, H.H., McNamara, E.R. & Alexander, E.A. 1984. Effect of acute thyroparathyroidectomy on nephron acidification. Am J Physiol 246, F569-F574.
7. Berdud, I., Martin-Malo, A., Almaden, Y., Aljama, P., Rodriguez, M. & Felsenfeld, A.J. 1998. The PTH-calcium relationship during a range of infused PTH doses in the parathyroidectomized rat. Calcif Tissue Int 62, 457-461.
8. Bichara, M., Mercier, O., Paillard, M. & Leviel, F. 1986. Effects of parathyroid hormone on urinary acidification. Am J Physiol 251, F444-F453.
9. Brown, D., Hirsch, S. & Gluck, S. 1988. Localization of a proton-pumping ATPase in rat kidney. J Clin Invest 82, 2114-2126.
10. Choi, I., Aalkjaer, C., Boulpaep, E.L. & Boron, W.F. 2000. An electroneutral sodium/bicarbonate cotransporter NBCn1 and associated sodium channel. Nature 405, 571-575.
11. Crumb, C.K., Martinez-Maldonado, M., Eknoyan, G. & Suki, W.N. 1974. Effects of volume expansion, purified parathyroid extract, and calcium on renal bicarbonate absorption in the dog. J Clin Invest 54, 1287-1294.
12. Eladari, D., Blanchard, A., Leviel, F., Paillard, M., Stuart-Tilley, A.K., Alper, S.L. & Podevin, R.A. 1998. Functional and molecular characterization of luminal and basolateral Cl-/HCO-3 exchangers of rat thick limbs. Am J Physiol 275, F334-F342.
13. Frische, S., Kwon, T.H., FrokiAEr, J., Madsen, K.M. & Nielsen, S. 2003. Regulated expression of pendrin in rat kidney in response to chronic NH4Cl or NaHCO3 loading. Am J Physiol Renal Physiol 284, F584-F593.
14. Frische, S., Zolotarev, A.S., Kim, Y.H., Praetorius, J., Alper, S., Nielsen, S. & Wall, S.M. 2004. AE2 isoforms in rat kidney: immunohistochemical localization and regulation in response to chronic NH4Cl loading. Am J Physiol Renal Physiol 286, F1163-F1170.
15. Girardi, A.C., Titan, S.M., Malnic, G. & Reboucas, N.A. 2000. Chronic effect of parathyroid hormone on NHE3 expression in rat renal proximal tubules. Kidney Int 58, 1623-1631.
16. Good, D.W. 1990. Bicarbonate absorption by the thick ascending limb of Henle's loop. Semin Nephrol 10, 132-138.
17. Heinemann, H.O. 1965. Metabolic alkalosis in patients with hypercalcemia. Metabolism 14, 1137-1152.
18. Huber, S., Asan, E., Jons, T., Kerscher, C., Puschel, B. & Drenckhahn, D. 1999. Expression of rat kidney anion exchanger 1 in type A intercalated cells in metabolic acidosis and alkalosis. Am J Physiol 277, F841-F849.
19. Hulter, H.N. & Peterson, J.C. 1985. Acid-base homeostasis during chronic PTH excess in humans. Kidney Int 28, 187-192.
20. Hulter, H.N., Sebastian, A., Toto, R.D., Bonner, E.L. Jr & Ilnicki, L.P. 1982. Renal and systemic acid-base effects of the chronic administration of hypercalcemia-producing agents: calcitriol, PTH, and intravenous calcium. Kidney Int 21, 445-458.
21. Hulter, H.N., Toto, R.D., Ilnicki, L.P., Halloran, B. & Sebastian, A. 1983. Metabolic alkalosis in models of primary and secondary hyperparathyroid states. Am J Physiol 245, F450-F461.
22. Kim, Y.H., Kwon, T.H., Frische, S., Kim, J., Tisher, C.C., Madsen, K.M. & Nielsen, S. 2002. Immunocytochemical localization of pendrin in intercalated cell subtypes in rat and mouse kidney. Am J Physiol Renal Physiol 283, F744-F754.
23. Kim, Y.H., Kwon, T.H., Christensen, B.M., Nielsen, J., Wall, S.M., Madsen, K.M., FrokiAEr, J. & Nielsen, S. 2003. Altered expression of renal acid-base transporters in rats with lithium-induced NDI. Am J Physiol Renal Physiol 285, F1244-F1257.
24. Kwon, T.H., Fulton, C., Wang, W., Kurtz, I., FrokiAEr, J., Aalkjaer, C. & Nielsen, S. 2002. Chronic metabolic acidosis upregulates rat kidney Na-HCO cotransporters NBCn1 and NBC3 but not NBC1. Am J Physiol Renal Physiol 282, F341-F351.
25. Leviel, F., Eladari, D., Blanchard, A., Poumarat, J.S., Paillard, M. & Podevin, R.A. 1999. Pathways for HCO-3 exit across the basolateral membrane in rat thick limbs. Am J Physiol 276, F847-F856.
26. Mercier, O., Bichara, M., Paillard, M. & Prigent, A. 1986. Effects of parathyroid hormone and urinary phosphate on collecting duct hydrogen secretion. Am J Physiol 251, F802-F809.
27. Mitnick, P., Greenberg, A., Coffman, T., Kelepouris, E., Wolf, C.J. & Goldfarb, S. 1982. Effects of two models of hypercalcemia on renal acid base metabolism. Kidney Int 21, 613-620.
28. Parks, J.H., Worcester, E.M., Coe, F.L., Evan, A.P. & Lingeman, J.E. 2004. Clinical implications of abundant calcium phosphate in routinely analyzed kidney stones. Kidney Int 66, 777-785.
29. Praetorius, J., Kim, Y.H., Bouzinova, E.V., Frische, S., Rojek, A., Aalkjaer, C. & Nielsen, S. 2004. NBCn1 is a basolateral Na+-. Am J Physiol Renal Physiol 286, F903-F912.
30. Quentin, F., Eladari, D., Frische, S., Cambillau, M., Nielsen, S., Alper, S.L., Paillard, M. & Chambrey, R. 2004. Regulation of the Cl-/. J Am Soc Nephrol 15, 2988-2997.
31. Sabolic, I., Brown, D., Gluck, S.L. & Alper, S.L. 1997. Regulation of AE1 anion exchanger and H(+)-ATPase in rat cortex by acute metabolic acidosis and alkalosis. Kidney Int 51, 125-137.
32. Wagner, C.A., Finberg, K.E., Stehberger, P.A., Lifton, R.P., Giebisch, G.H., Aronson, P.S. & Geibel, J.P. 2002. Regulation of the expression of the Cl-/anion exchanger pendrin in mouse kidney by acid-base status. Kidney Int 62, 2109-2117.
33. Wang, W., Li, C., Kwon, T.H., Miller, R.T., Knepper, M.A., FrokiAEr, J. & Nielsen, S. 2004. Reduced expression of renal Na+ transporters in rats with PTH-induced hypercalcemia. Am J Physiol Renal Physiol 286, F534-F545.