Behavioural effects in mice and intoxication symptomatology of weak neurotoxin from cobra Naja kaouthia

Basic and Clinical Pharmacology and Toxicology

Volumn 100, Issue 4, 2007, Pages 273-278

  Mordvintsev, Dmitry Y ^a   Rodionov, Dmitry I ^a   Makarova, Mariya V ^a   Kamensky, Andrey A ^b   Levitskaya, Natalya G ^b   Ogay, Alexey Y ^a   Rzhevsky, Dmitry I ^a   Murashev, Arkady N ^a   Tsetlin, Victor I ^a   Utkin, Yuri N ^a  

^a SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

^b MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINERGIC RECEPTOR; MUSCARINIC RECEPTOR; NEUROTOXIN; SNAKE VENOM;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXPLORATORY BEHAVIOR; FEMALE; HEMODYNAMICS; IN VITRO STUDY; IN VIVO STUDY; INTOXICATION; LOCOMOTION; MALE; MOUSE; NEUROTOXICITY; NONHUMAN; ORIENTATION; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; SNAKE; TASK PERFORMANCE;

ACOUSTIC STIMULATION; ANIMALS; BEHAVIOR, ANIMAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COBRA NEUROTOXINS; DEFECATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENOUS; MALE; MICE; MOTOR ACTIVITY; NEUROTOXICITY SYNDROMES; NEUROTOXINS; REACTION TIME; RESPIRATORY INSUFFICIENCY; SALIVATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TEMPERATURE SENSE; TIME FACTORS;

MUS; NAJA KAOUTHIA; RATTUS;

EID: 33947191564     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2007.00045.x     Document Type: Article

References (27)

1. Carlsson FHH. Snake venom toxins; the primary structure of protein S4C11; a neurotoxin homologue from the venom of forest cobra (Naja melanoleuca). Biochim Biophys Acta 1975;400:310-21.
2. 4 from Dendroaspis jamesoni Kaimosae (Jameson's mamba). S Afr J Chem 1979;32:151-5.
3. Shafquat J, Siddiqi AR, Zaidi ZH, Jornvall H. Extensive multiplicity of the miscellaneous type of neurotoxins from the venom of the cobra Naja naja naja and structural characterization of major components. FEBS Lett 1991;284:70-2.
4. Servent D, Menez A. Snake neurotoxins that interact with nicotinic acetylcholine receptors. In: Massaro EJ (ed.). Handbook of Neurotoxicology, Vol. 1. Humana Press, Totowa, NJ, 2001;385-425.
5. Nirthanan S, Gopalokrishnakone P, Gwee MCE, Khoo HE, Kini RM. Non-conventional toxins from Elapidae venoms. Toxicon 2003;41:397-407.
6. Tsetlin VI. Snake venom alpha-neurotoxins and other 'three-finger' proteins. Eur J Biochem 1999;264:281-6.
7. Kini RM. Molecular moulds with multiple missions: functional sites of three-finger toxins. Clin Exp Pharmacol Physiol 2002;29:815-22.
8. Nirthanan S, Gwee MCE. Three-finger neurotoxins and the nicotinic acetylcholine receptor, forty years on. J Pharm Sci 2004;94:1-17.
9. Menez A. Function architecture of animal toxins: a clue to drug design? Toxicon 1998;36:1557-72.
10. Kordis D, Gubensek F. Adaptive evolution of animal toxin multigene families. Gene 2000;261:43-52.
11. Aird SD, Womble GC, Yates JR, Griffin PR. Primary structure of γ-bungarotoxin, a new postsynaptic neurotoxin from venom of Bungarus multicinstus. Toxicon 1999;37:609-25.
12. Nirthanan S, Charpantier E, Gopalakrishnakone P et al. Candoxin, a novel toxin from Bungarus candidus, is a reversible antagonist of muscle (α2βγδ) but a poorly reversible antagonist of neuronal α7 nicotinic acetylcholine receptors. J Biol Chem 2002;277:17,811- 20.
13. Ogay AY, Rzhevsky DI, Murashev AN, Tsetlin VI, Utkin YN. Weak neurotoxin from Naja kaouthia cobra venom affects haemodynamic regulation by acting on acetylcholine receptors. Toxicon 2005;45:93-9.
14. Utkin YuN, Kukhtina VV, Maslennikov IV et al. First tryptophan-containing weak toxin from cobra venom. Toxicon 2001;39:921-7.
15. Utkin YuN, Kukhtina VV, Kryukova EV et al. Weak toxin from Naja kaouthia is a nontoxic antagonist of α7 and muscle-type nicotinic acetylcholine receptors. J Biol Chem 2001;276:15,810-5.
16. Chang LS, Lin SR, Wang JJ, Hu WP, Wu BN, Huang HB. Structure-function studies on Taiwan cobra long neurotoxin homologue. Biochim Biophys Acta 2000;1480:293-301.
17. Poh SL, Mourier G, Thai R et al. A synthetic weak neurotoxin binds with low affinity to Torpedo and chicken α7 nicotinic acetylcholine receptor. Eur J Biochem 2002;269:4247-56.
18. Chang LS, Chung C, Wu B, Yang C. Characterization and gene organization of Taiwan banded krait (Bungarus multicinctus) γ-bungarotoxin. J Protein Chem 2002;21:223-9.
19. Nirthanan S, Charpantier E, Gopalakrishnakone P et al. Neuromuscular effects of candoxin, a novel toxin from the venom of the Malayan krait (Bungarus candidus). Br J Pharmacol 2003;139:832-44.
20. Osipov AV, Levashov MY, Tsetlin VI, Utkin YN. Cobra venom contains a pool of cysteine-rich secretory proteins. Biochem Biophys Res Commun 2005;328:177-82.
21. Irwin S. Comprehensive observational assessment: a systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. Psychopharmacologia 1968;13:222-57.
22. Taylor P, Brown JH. Acetylcholine. In: Siegel GL, Agranoff BW, Albers RW, Fisher SK, Uhler MP (eds). Basic Neurochemistry: Molecular, Cellular and Medical Aspects, 6th edition. Lippincott-Raven Publishers, Philadelphia, electronic edition. 1999.
23. Järv J. Neurotoxic agents interacting with the muscarinic acetylcholine receptor. In: Herken H, Hucho F (eds). Handbook of Experimental Pharmacology, Vol. 102. Springer Verlag, Berlin, 1992;659-80.
24. Kukhtina VV, Weise C, Osipov AV et al. The MALDI mass-spectrometry in the identification of new proteins in snake venom. Bioorgan Khim 2000;26:803-7.
25. Laterra J, Keep RF, Betz L, Goldstein GW. Blood-brain-cerebrospinal fluid barriers. In: Siegel GL, Agranoff BW, Albers RW, Fisher SK, Uhler MP (eds). Basic Neurochemistry: Molecular, Cellular and Medical Aspects, 6th edition. Lippincott-Raven publishers, Philadelphia, electronic edition. 1999.
26. Michel AD, Whiting RL. Methoctramine reveals heterogeneity of M2 muscarinic receptors in longitudinal ileal smooth muscle membranes. Eur J Pharmacol 1988;145:305-11.
27. Nakamura T, Matsui M, Uchida K et al. M(3) muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice. J Physiol 2004;558:561-75.