An assessment of recombinant human erythropoietin effect on reticulocyte production rate and lifespan distribution in healthy subjects

Pharmaceutical Research

Volumn 24, Issue 4, 2007, Pages 758-772

  Krzyzanski, Wojciech ^a   Perez Ruixo, Juan Jose ^b,c  

^a UNIVERSITY AT BUFFALO   (United States)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^c MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

Author keywords

Lifespan; NONMEM; Pharmacodynamic model; Precursor successor relationship; Recombinant human erythropoietin

Indexed keywords

RECOMBINANT ERYTHROPOIETIN;

ADULT; ARTICLE; CELL SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG RESPONSE; ERYTHROCYTE COUNT; ERYTHROPOIESIS; HEMATOLOGICAL PARAMETERS; HEMATOPOIESIS; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RETICULOCYTE; RETICULOCYTE COUNT; SINGLE DRUG DOSE;

CELL SURVIVAL; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTE COUNT; ERYTHROPOIETIN, RECOMBINANT; HEMATINICS; HUMANS; INJECTIONS, SUBCUTANEOUS; MALE; MODELS, BIOLOGICAL; PREDICTIVE VALUE OF TESTS; REFERENCE VALUES; RETICULOCYTES; RETICULOCYTOSIS; TIME FACTORS;

EID: 33947188218     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-006-9195-y     Document Type: Article

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