Novel 1-oxyl-2-substitutedphenyl-4,4,5,5-tetramethylimidazolines: Synthesis, selectively analgesic action, and QSAR analysis

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 8, 2007, Pages 2815-2826

  Zhao, Ming ^a   Li, Zheng ^a   Peng, Li ^a   Tang, Yu Rong ^c   Wang, Chao ^b   Zhang, Ziding ^c   Peng, Shiqi ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

^c CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

Analgesic; QSAR; Tetramethylimidazoline; Vasorelaxation

Indexed keywords

1 OXYL 2 (2' FLUOROPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE; 1 OXYL 2 (2' HYDROXYLPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE; 1 OXYL 2 (2' NITROPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE; 1 OXYL 2 (2',4' DICHLOROPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE; 1 OXYL 2 (2',4' DIMETHOXYLPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE; 1 OXYL 2 (3' HYDROXY 4' METHOXYPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE; 1 OXYL 2 (3' HYDROXYLPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE; 1 OXYL 2 (3' METHOXYL 4' HYDROXYPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE; 1 OXYL 2 (3' NITROPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE; 1 OXYL 2 (3',4' DICHLOROPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE; 1 OXYL 2 (3',4' DIMETHOXYLPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE; 1 OXYL 2 (3',4' METHYLENDIOXYPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE; 1 OXYL 2 (4' BROMOPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE; 1 OXYL 2 (4' CHLOROPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE; 1 OXYL 2 (4' HYDROXYLPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE; 1 OXYL 2 (4' METHOXYPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE; 1 OXYL 2 (4' METHYLPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE; 1 OXYL 2 (4' N,N DIMETHYLPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE; 1 OXYL 2 (4' NITROPHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE; 1 OXYL 2 (PHEN 1' YL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE; ANALGESIC AGENT; IMIDAZOLINE DERIVATIVE; NORADRENALIN; PROSTACYCLIN RECEPTOR; SODIUM CHLORIDE; UNCLASSIFIED DRUG; VASODILATOR AGENT;

ACCURACY; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; AORTA STRIP; ARTICLE; BLEEDING TIME; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; MOUSE; MULTIPLE LINEAR REGRESSION ANALYSIS; NONHUMAN; PAIN THRESHOLD; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RISK; TAIL; VASODILATATION;

ALGORITHMS; ANALGESICS; ANIMALS; AORTA, THORACIC; BLEEDING TIME; BLOOD COAGULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; IMIDAZOLINES; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MICE, INBRED ICR; MUSCLE RELAXATION; NOREPINEPHRINE; PAIN THRESHOLD; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; RECEPTORS, EPOPROSTENOL; REGRESSION ANALYSIS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, INFRARED; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS;

MUS; RATTUS;

EID: 33947167863     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.02.023     Document Type: Article

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