Clavaminols A-F, novel cytotoxic 2-amino-3-alkanols from the ascidian Clavelina phlegraea

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 8, 2007, Pages 2920-2926

  Aiello, Anna ^a   Fattorusso, Ernesto ^a   Giordano, Antonella ^a   Menna, Marialuisa ^a   Navarrete, Carmen ^b   Muñoz, Eduardo ^b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF CÓRDOBA   (Spain)

Author keywords

Amino alcohols; Ascidians; Cytotoxic compounds; Marine natural products

Indexed keywords

ALKANOL; ANTINEOPLASTIC AGENT; CLAVAMINOL A; CLAVAMINOL B; CLAVAMINOL C; CLAVAMINOL D; CLAVAMINOL E; CLAVAMINOL F; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; ASCIDIACEA; BREAST CARCINOMA; CELL DEATH; CLAVELINA PHLEGRAEA; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; LUNG CARCINOMA; SPECTROSCOPY; STOMACH CARCINOMA;

AMINO ALCOHOLS; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA DAMAGE; FLUORESCEINS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT; STEREOISOMERISM; UROCHORDATA;

ASCIDIA; ASCIDIACEA; CLAVELINA;

EID: 33947157748     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.02.015     Document Type: Article

References (16)

1. Jares-Erijman E.A., Bapat C.P., Lithgow-Bertelloni A., Rinehart K.L., and Sakai R. J. Org. Chem. 58 (1993) 5732
2. Garrido L., Zubia E., Ortega M.J., Naranjo S., and Salva J. Tetrahedron 57 (2001) 4579
3. Kossuga M.H., MacMillan J.B., Rogers E.W., Molinski T.F., Nascimento G.G.F., Rocha R.M., and Berlinck R.G.S. J. Nat. Prod. 67 (2004) 1879
4. Gulavita N.K., and Scheuer P.J. J. Org. Chem. 54 (1989) 366
5. Jiménez C., and Crews P. J. Nat. Prod. 53 (1990) 978
6. Clark R.J., Garson M.J., and Hooper J.N.A. J. Nat. Prod. 64 (2001) 1568
7. Cuadros R., Montejo de Garcini E., Wandosell F., Faircloth G., Fernàndez-Sousa J.M., and Avila J. Cancer Lett. 152 (2000) 23
8. Kawai M., Nagai U., and Katsumi M. Tetrahedron Lett. (1975) 3165
9. Nicholas G.M., and Molinski T.F. J. Am. Chem. Soc. 122 (2000) 4011
10. Searle P.A., and Molinski T.F. J. Org. Chem. 58 (1993) 7578
11. Dorman D.E., Jautelat M., and Roberts J.D. J. Org. Chem. 36 (1971) 2757
12. Ivanciuc O., Rabine J.- P., Cabrol-Bass D., Panaye A., and Doucet P. J. Chem. Inf. Comput. Sci. 37 (1997) 587
13. Charan R.D., Garson M.J., Brereton I.M., Willis A.C., and Hooper J.N.A. Tetrahedron 52 (1996) 9111
14. Castedo M., Perfettini J.L., Roumier T., and Kroemer G. Cell Death Differ. 9 (2002) 1287
15. Ferri K.F., and Kroemer G. Nat. Cell Biol. 4 (2000) E63
16. Macho A., Lucena C., Calzado M.A., Blanco M., Donnay I., Appendino G., and Munoz E. Chem. Biol. 7 (2000) 483