A conformational transition in the adenylyl cyclase catalytic site yields different binding modes for ribosyl-modified and unmodified nucleotide inhibitors

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 8, 2007, Pages 2993-3002

  Wang, Jenna L ^a   Guo, Jian Xin ^a,b   Zhang, Qi Yuan ^c   Wu, Jay J Q ^b   Seifert, Roland ^d   Lushington, Gerald H ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b VM Discovery   (United States)

^c INSTITUTE OF CHEMISTRY   (China)

^d UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Adenylyl cyclase; Conformational transition; MANT substituted nucleotides; Molecular modeling

Indexed keywords

ADENYLATE CYCLASE; ADENYLATE CYCLASE INHIBITOR;

ARTICLE; BINDING SITE; CATALYSIS; COMPUTER MODEL; CONFORMATIONAL TRANSITION; CORRELATION ANALYSIS; DECOMPOSITION; ENZYME ACTIVE SITE; LIGAND BINDING;

ADENYLATE CYCLASE; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; INDICATORS AND REAGENTS; KINETICS; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NUCLEOTIDES; PHOSPHATES; PURINES; PYRIMIDINES; RIBOSE;

EID: 33947144815     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.02.014     Document Type: Article

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