Aerosol-derived airway morphometry (ADAM) in patients with lung emphysema diagnosed by computed tomography - Reproducibility, diagnostic information and modelling

European Journal of Medical Research

Volumn 12, Issue 2, 2007, Pages 74-83

  Lehnigk, B ^a   Schleiss, M ^a   Brand, P ^b,c   Heyder, J ^b   Magnussen, H ^a   Jörres, Rudolf A ^a,d  

^a KRANKENHAUS GROSSHANSDORF   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c Inamed Research GmbH and Co KG   (Germany)

^d LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Airway dimensions; Diagnostic power; Lung model; Parametric fitting

Indexed keywords

ADULT; AEROSOL; AGED; AIRWAY OBSTRUCTION; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC IMAGING; DIAGNOSTIC VALUE; DISEASE SEVERITY; FEMALE; FORCED EXPIRATORY VOLUME; HIGH RESOLUTION COMPUTER TOMOGRAPHY; HUMAN; LUNG EMPHYSEMA; LUNG MODEL; MAJOR CLINICAL STUDY; MALE; MORPHOMETRICS;

ADULT; AEROSOLS; AGED; AGED, 80 AND OVER; DECANOIC ACIDS; FEMALE; HUMANS; LUNG; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; PULMONARY EMPHYSEMA; PULMONARY VENTILATION; RESPIRATORY FUNCTION TESTS; SENSITIVITY AND SPECIFICITY; TOMOGRAPHY, X-RAY COMPUTED;

EID: 33947143025     PISSN: 09492321     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Heyder J. Assessment of airway geometry with inert aerosols. J Aerosol Med. 1989(2): 89-97.
2. Kohlhäufl M, Brand P, Häussinger K, Scheuch G, Schulz H, Heyder J. Pneumologic diagnosis with model aerosols - 1: Intrapulmonary morphometry. Principles and initial results of clinical research (German). Pneumologie. 1997(51): 40-46.
3. Thurlbeck WM, Simon G. Radiographic appearence of the chest in emphysema. Am J Roentgenol. 1978(130): 429-440.
4. Gelb AF, Hogg JC, Müller NL, Schein MJ, Kuei J, Tashkin DP, Epstein JD, Kollin J, Green RH, Zamel N, Elliott WM, Hadjiaghai LN. Contribution of emphysema and small airways in COPD. Chest. 1996(109): 353-359.
5. Rosenthal FS. Aerosol deposition and dispersion characterize lung injury in a canine model of emphysema. J Appl Physiol. 1995(78): 1585-1595.
6. Beinert T, Brand P, Behr J, Vogelmeier C, Heyder J. Peripheral airspace dimensions in patients with COPD. Chest 1995(108): 998-1003.
7. Siekmeier, R, Joder S, Wiewrodt R, Stahlhofen W, Caspary W, Buhl R. Aerosol-derived airway dimensions and conventional lung function parameters in patients with hereditary alpha 1-antitrypsin deficiency. Eur J Respir Dis. 1995; 8: A209 (abstract).
8. Zeman KL, Mascarella JJ, Bennett WD. Abnormal effective airway diameters (EADs) associated with COPD are related to impaired pulmonary function. J Aerosol Med. 1995; 8: A126 (abstract).
9. Brand P, Beinert T, Fruhmann G, Hillebrecht A, Heyder J. Aerosol derived airway morphometry at different levels of lung inflation. J Aerosol Med. 1993; 6: 165-176.
10. Brand P, Rieger C, Beinert Z, Heyder J. Aerosol derived airway morphometry in healthy subjects. Eur Respir J. 1995; 8: 1639-1646.
11. Thurlbeck WM, Müller NL. Emphysema: Definition, imaging, and quantification. Am J Roentgenol. 1994; 163: 1017-1025.
12. Kohlhäufl M, Brand P, Selzer Z, Scheuch G, Meyer T, Weber N, Schulz H, Häussinger K, Heyder J. Diagnosis of emphysema in patients with chronic bronchitis - a new approach. Eur Respir J. 1998; 12: 793-798.
13. Kohlhäufl M, Brand P, Rock C, Radons T, Scheuch G, Meyer T, Schulz H, Pfeifer KJ, Häussinger K, Heyder J. Noninvasive diagnosis of emphysema: aerosol morphometry and aerosol bolus dispersion in comparison to HRCT. Am J Respir Crit Care Med. 1999; 160: 913-918.
14. Brand P, Letzel S, Buchta M, Scheuch G, Windorfer K, Hilla W, Smith HJ, Kraus T. Can aerosol-derived airway morphometry detect early, asymptomatical lung emphysema? J Aerosol Med. 2003; 16: 143-151.
15. Lehnigk B, Schleiss M, Jörres R, Magnussen H, Vogt-Ladner G, Schmid M, Worth H, Brand P, Kohlhäufl M, Schulz H, Häußinger K, Heyder J. Non-invasive definition of dimensions of peripheral lung structures via aerosol morphometry: present knowledge and perspectives (German). Pneumologie. 2001; 55: 279-288.
16. American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1995; 152: S77-S120.
17. Quanjer PH (ed). Standardized lung function testing. Eur Respir J. 1993; 6(suppl 16): 5-100.
18. Bergin C, Müller NL, Nichols DM, Lillington G, Hogg JC, Mullen B, Grymalowski MR, Osborne S, Paré PD. The diagnosis of emphysema. Am Rev Respir Dis. 1986; 133: 541-546.
19. Miller RR, Müller NL, Vedal S, Morrison NJ, Staples CA. Limitations of computed tomography in the assessment of emphysema. Am Rev Respir Dis. 1989; 139: 980-983.
20. Rosenthal FS. Lung structure parameters estimated from modeling aerosol deposition in isolated dog lungs. J Appl Physiol. 1989; 67: 2014-2025.
21. Brand P, Kohlhäufl M, Meyer T, Selzer T, Heyder J, Häußinger K. Aerosol-derived airway morphometry and aerosol bolus dispersion in patients with lung fibrosis and lung emphysema. Chest 1999; 116: 543-548.
22. Brand P, Selzer T, Tuch T, Schulz A, Heyder J. Accuracy and resolution power of aerosol derived airway morphometry in a simple lung model. Exp Lung Res. 1994; 20: 185-205.
23. Haefli-Bleuer B, Weibel E. Morphometry of the human pulmonary acinus. Anat Rec. 1988; 220: 401-414.
24. Nikiforov AI, Lippmann M, Palmes FD. Validation of an in vivo aerosol probe technique by measurement of deposition and morphometry in exised human lungs. Ann Occup Hyg. 1988; 32: 33-39.
25. Thurlbeck WM. The internal surface area of nonemphysematous lungs. Am Rev Respir Dis. 1967; 95: 765-773.
26. Sanders C. The radiographic diagnosis of emphysema. Radiol Clin North Am. 1991; 29: 1019-1030.
27. Loubeyre P, Paret M, Revel D, Wiesendanger T, Brune J. Thin-section CT detection of emphysema associated with bronchiectasis and correlation with pulmonary function tests. Chest. 1996; 109: 360-365.
28. Shaker SB, Maltbaek N, Brand P, Haeussermann S, Dirksen A. Quantitative computed tomography and aerosol morphometry in COPD and a1-antitrypsin deficiency. Eur Respir J. 2005; 25: 23-30.
29. MacNee W, Gould G, Lamb D. Quantifying emphysema by CT scanning. Ann NY Acad Sci. 1991; 624: 179-194.
30. Gevenois PA, Yernault JC. Can computed tomography quantify pulmonary emphysema? Eur Respir J 1995; 5: 843-848.
31. Müller NL, Miller RR, Staples CA, Abboud RT. "Density Mask" An objective method to quantitate emphysema using computed tomography. Chest. 1988; 94: 782-787.