Topical testosterone versus clobetasol for vulvar lichen sclerosus

International Journal of Gynecology and Obstetrics

Volumn 96, Issue 2, 2007, Pages 117-121

  Ayhan, A ^a   Guven, S ^a   Guvendag Guven, E S ^a   Sakinci, M ^a   Gultekin, M ^a   Kucukali, T ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Clobetasol; ; Testosterone; ; Topical treatment; ; Vulvar lichen sclerosus

Indexed keywords

CLOBETASOL; CLOBETASOL PROPIONATE; TESTOSTERONE;

ADULT; AGED; ARTICLE; BIOPSY TECHNIQUE; CONTROLLED STUDY; FEMALE; HUMAN; HYSTERECTOMY; LICHEN SCLEROSUS ET ATROPHICUS; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; POSTMENOPAUSE; PRIORITY JOURNAL; RECURRENCE RISK; REMISSION; RETROSPECTIVE STUDY; SYMPTOMATOLOGY; VULVA DISEASE;

EID: 33947140949     PISSN: 00207292     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijgo.2006.09.018     Document Type: Article

References (25)

1. Jones R.W., Sadler L., Grant S., Whineray J., Exeter M., and Rowan D. Clinically identifying women with vulvar lichen sclerosus at increased risk of squamous cell carcinoma: a case-control study. J Reprod Med 49 (2004) 808-811
2. Smith Y.R., and Haefner H.K. Vulvar lichen sclerosus: pathophysiology and treatment. Am J Clin Dermatol 5 (2004) 105-125
3. Lorenz B., Kaufman R.H., and Kutzner S.K. Lichen sclerosus: therapy with clobetasol propionate. J Reprod Med 43 (1998) 790-794
4. Wilkinson E.J. Benign vulvovaginal disorders. In: Scott J.R. (Ed). Danforth's obstetrics and gynecology. 9th ed. (2003), Lippincott Williams & Wilkins, Philadelphia, Pa 606-607 [chapter 33]
5. Cattaneo A., De Marco A., Sonni L., Bracco G.L., Carli P., and Taddei G.L. Clobetasol vs. testosterone in the treatment of lichen sclerosus of the vulvar region. Minerva Ginecol 44 (1992) 567-571
6. Bracco G.L., Carli P., Sonni L., Maestrini G., De Marco A., Taddei G.L., et al. Clinical and histologic effects of topical treatments of vulval lichen sclerosus: a critical evaluation. J Reprod Med 38 (1993) 37-40
7. Cattaneo A., Carli P., De Marco A., Sonni L., Bracco G., De Magnis A., et al. Testosterone maintenance therapy. Effects on vulvar lichen sclerosus treated with clobetasol propionate. J Reprod Med 41 (1996) 99-102
8. Bornstein J., Heifetz S., Kellner Y., Stolar Z., and Abramovici H. Clobetasol dipropionate 0.05% versus testosterone propionate 2% topical application for severe vulvar lichen sclerosus. Am J Obstet Gynecol 178 (1998) 80-84
9. Kaufman R.H., Gardner H.L., Brown Jr. D., and Beyth Y. Vulvar dystrophies: an evaluation. Am J Obstet Gynecol 120 (1974) 363-367
10. Cattaneo A., Bracco G.L., Maestrini G., Carli P., Taddei G.L., Colafranceschi M., et al. Lichen sclerosus and squamous hyperplasia of the vulva. A clinical study of medical treatment. J Reprod Med 36 (1991) 301-305
11. Gadducci A., Facchini V., Del Bravo B., Dell'Arciprete T., Madrigali A., and Fioretti P. The topical administration of steroids in the treatment of typical vulvar dystrophies. Clin Exp Obstet Gynecol 16 (1989) 12-15
12. Ayhan A., Urman B., Yuce K., Ayhan A., and Gokoz A. Topical testosterone for lichen sclerosus. Int J Gynecol Obstet 30 (1989) 253-255
13. Paslin D. Treatment of lichen sclerosus with topical dihydrotestosterone. Obstet Gynecol 78 (1991) 1046-1049
14. Wright A.J. Testosterone pellet implant therapy for lichen sclerosus. Mo Med 90 (1993) 711-713
15. Sideri M., Origoni M., Spinaci L., and Ferrari A. Topical testosterone in the treatment of vulvar lichen sclerosus. Int J Gynecol Obstet 46 (1994) 53-56
16. Zorlu C.G., and Cobanoglu O. Medical treatment of squamous hyperplasia and lichen sclerosus of the vulva. Int J Gynecol Obstet 51 (1995) 235-238
17. Joura E.A., Zeisler H., Bancher-Todesca D., Sator M.O., Schneider B., and Gitsch G. Short-term effects of topical testosterone in vulvar lichen sclerosus. Obstet Gynecol 89 (1997) 297-299
18. Kohlberger P.D., Joura E.A., Bancher D., Gitsch G., Breitenecker G., and Kieback D.G. Evidence of androgen receptor expression in lichen sclerosus: an immunohistochemical study. J Soc Gynecol Investig 5 (1998) 331-333
19. Meyrick Thomas R.H., Ridley C.M., McGibbon D.H., and Black M.M. Lichen sclerosus et atrophicus and autoimmunity: a study of 350 women. Br J Dermatol 118 (1988) 41-46
20. Clark T.J., Etherington I.J., and Luesley D.M. Response of vulvar lichen sclerosus and squamous cell hyperplasia to graduated topical steroids. J Reprod Med 44 (1999) 958-962
21. Fischer G., and Rogers M. Treatment of childhood vulvar lichen sclerosus with potent topical corticosteroid. Pediatr Dermatol 14 (1997) 235-238
22. Sinha P., Sorinola O., and Luesley D.M. Lichen sclerosus of the vulva: long-term steroid maintenance therapy. J Reprod Med 44 (1999) 621-624
23. Diakomanolis E.S., Haidopoulos D., Syndos M., Rodolakis A., Stefanidis K., Chatzipapas J., et al. Vulvar lichen sclerosus in postmenopausal women: a comparative study for treating advanced disease with clobetasol propionate 0.05%. Eur J Gynaecol Oncol 23 (2002) 519-522
24. Cooper S.M., Gao X.H., Powell J.J., and Wojnarowska F. Does treatment of vulvar lichen sclerosus influence its prognosis?. Arch Dermatol 140 (2004) 702-706
25. Renaud-Vilmer C., Cavelier-Balloy B., Porcher R., and Dubertret L. Vulvar lichen sclerosus: effect of long-term topical application of a potent steroid on the course of the disease. Arch Dermatol 140 (2004) 709-712