Antagonism of antinociceptive effect of hydro-ethanolic extract of Hypericum perforatum Linn. by a non selective opioid receptor antagonist, naloxone

Pakistan Journal of Biological Sciences

Volumn 10, Issue 5, 2007, Pages 792-796

  Subhan, Fazal ^a   Khan, M ^a   Ibrar, M ^a   Nazar ul Islam, ^a   Khan, A ^b   Gilani, A H ^b  

^a UNIVERSITY OF PESHAWAR   (Pakistan)

^b AGA KHAN UNIVERSITY MEDICAL COLLEGE   (Pakistan)

Author keywords

Antinociceptive effect; Hypericum perforatum; Mice; Opioid receptors

Indexed keywords

ANIMALIA; CLUSIACEAE; HYPERICUM PERFORATUM; MUS;

EID: 33947138212     PISSN: 10288880     EISSN: 18125735     Source Type: Journal    
DOI: 10.3923/pjbs.2007.792.796     Document Type: Article

References (19)

1. Di Carlo, D.G., F. Borrelli, A.A. Izzo and E. Ernest, 2001. St John's wort. Prozac from the Plant kingdom. Trends Pharmacol., Sci., 22: 292-297.
2. Duke, J.A., 1992. Handbook of Phytochemical Constituents of GRAS Herbs and other economical Plants. London: CRC Press, pp: 302.
3. Gilani, A.H., A. Khan, F. Subhan and M. Khan, 2005. antisposmodic and bronchodilator activities of St John's wort are putatively mediated through dual inhibition of calcium influx and phosphodiaestrases Fund. Clin. Pharmacol. J. Compilation, 19: 695-705.
4. Girzu, M.A., A.M. Carnat, J. Privat, A.P. Fialip and J.L. Carnat, 1997. Sedative activity in mice of a hydroalcohol extract of Hyparicum perforatum. Phytother. Res., 11: 395-397.
5. Gray, A.M., P.S.J. Spencer and R.D.E. Sewell, 1998. The involvement of the opioidergic system in the antinociceptive mechanism of action of antidepressant compounds. Br. J. Pharmacol., 124: 669-674.
6. Kasper, S., 2001. Hypericum perforatum, a review of clinical studies. Pharmacopsychiatry, 34 (Supp. 1): 51-55.
7. Krishtal, O., N. Lozovaya, A. Fisunov, T. Tsintsadze, Y. Pankratov, M. Kopanitsa and S.S. Chatterjee, 2001. Modulation of ion channels in rat neurons by the constituents of Hyparicum perforatum. Pharmacopsychiatry, 34 (Supp. 1): S74-82.
8. Kumar, V., P.N. Singh and S.K. Bhattacharya, 2001. Anti-inflammatory and analgesia of Indian Hyparicum perforatum L. Ind. J. Exp. Biol., 39: 339-343.
9. Linde, K., G.T. Riet, M. Hondras, A. Vickers, R. Saller and D. Melchart, 2001. Systemic reviews of complementary therapies-an annotated bibliography. Part 2: Herbal medicine. BMC Complementary Alter Med., 1: 5.
10. Meruelo, D., G. Lavie and D. Lavie, 1988. Theraputic agents with dramatic antiretroviral activity and little toxicity at effective doses: Aromatic polycyclic diones hypericin and pseudohypericin. Proc. Natl. Acad. Sci., 85: 5230-5234.
11. Millan, M.J., K. Bervoets, J.M. Rivet, P. Widdowson, A. Renouard, S. Le Marouille-Girardon and A. Gobert, 1994. Multiple alpha2-A adrenergic subtypes, II. Evidence for a role of Rat R alpha-2A adrenergic receptors in the control of nociception motor behaviour and hippocampal synthesis of noradrenaline. J. Pharmacol. Exp. Ther., 270: 958-972.
12. Negrash, A.K. and P.Y. Pochinok, 1972. Comparative study of chemotherapeutic and pharmacological properties of antimicrobial preparations from common St. John's wort. Fitonotsidy Mater. Soveshch, 6: 198-200.
13. Rommelspacher, H., B. Siemanowitz and M. Mannel, 2001. Acute and Chronic actions of a dry methanolic extract of Hyparicum perforatum and a hyperforin-rich extract on dopaminergic and serotogenic neurons in rat nucleus accumbens. Pharmacopsychiatry, 34 (Supp. 1): S 119-126.
14. Sherwood, L., 1993. Human Physiology: From Cells to Systems. 2nd Edn., San Francisco: West Publishing Company.
15. Simmen, U., C. Schweitzer, W. Burkard, W. Schaffner and K. Lundstrom, 1998. Hyparicum perforatum inhibits the binding of mu- and kappa-opioid receptor expressed with the Semliki Forest Virus system. Pharm-Acta Helv., 73: 53-56.
16. Simmen, U., J. Higelin, Berger, K. Butter, W. Schaffner and K. Lundstorm, 2001. Neurochemical studies with St John's Wort in vitro. Pharmacopsychiatry, 34 (Supp. 1):S 137-142.
17. Vasilchenko, E.A., 1986. The analgesic effect of flavonoids of Rhododendron luteum Sweet, Hyparicum perforatum L., Lespedeza bicolor and Lespedeza hedysaroides. Rastit. Resur., 22: 12-21.
18. Wagner, H. and S. Bladt, 1994. Pharmaceutical quality of Hyparicum extract. J. Geriatr. Psychiatry Neurol., 7 (Supp. 1): 65-68.
19. Weiss, R.F., 1988. Herbal Medicine. Beaconsfield Publisher; Beaconsfield, England.