Interaction between the angiotensin-converting enzyme gene insertion/deletion polymorphism and obstructive sleep apnoea as a mechanism for hypertension

Journal of Hypertension

Volumn 25, Issue 4, 2007, Pages 779-783

  Boström, Kristina Bengtsson ^a,c   Hedner, Jan ^b   Melander, Olle ^a   Grote, Ludger ^b   Gullberg, Bo ^a   Råstam, Lennart ^a   Groop, Leif ^a   Lindblad, Ulf ^a,c,d  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^c R and D Centre Skaraborg Primary Care   (Sweden)

^d Skaraborgs Institutet   (Sweden)

Author keywords

Angiotensin converting enzyme gene; Case control study; Genetics; Hypertension; Obstructive sleep apnoea; Polymorphisms

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE;

ADULT; ARTICLE; BLOOD PRESSURE; BLOOD PRESSURE MEASUREMENT; CASE CONTROL STUDY; CONFIDENCE INTERVAL; CONTROLLED STUDY; FEMALE; GENE DELETION; GENE INSERTION; GENE INTERACTION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; POLYSOMNOGRAPHY; PRIMARY MEDICAL CARE; PRIORITY JOURNAL; RISK ASSESSMENT; SLEEP APNEA SYNDROME;

EID: 33947112891     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/HJH.0b013e328017f6d5     Document Type: Article

References (28)

1. Yaggi HK, Conato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V. Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med 2005; 353:2034-2041.
2. Marin JM, Carrizo SJ, Vicente E, Agusti AGN. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with positive airway pressure: an observational study. Lancet 2005; 365:1046-1053.
3. He J, Kryger MH, Zorick FL, Conway W, Roth T. Mortality and apnea index in obstructive sleep apnea. Experience in 385 male patients. Chest 1988; 94:9-14.
4. Nieto FJ, Young TB, Lind BK, Shahar E, Samet JM, Redline S, D'Agostino RB, et al., for the Sleep Heart Health Study. Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. JAMA 2000; 283:1829-1836.
5. Møller DS, Lind P, Strunge B, Pedersen EB. Abnormal vasoactive hormones and 24-hour blood pressure in obstructive sleep apnea. Am J Hypertens 2003; 16:274-280.
6. Fletcher C, Bao G, Li R. Renin activity and blood pressure in response to chronic episodic hypoxia. Hypertension 1999; 34:309-314.
7. Buxbaum SG, Elston RC, Tishler PV, Redline S. Genetics of the apnea hypopnea index in Caucasians and African Americans. I. Segregation analysis. Genet Epidemiol 2002; 22:243-53.
8. Lifton RP, Jeunemaitre X. Finding genes that cause human hypertension. J Hypertens 1993; 11:231-236.
9. Ward R. Familial aggregation and genetic epidemiology of blood pressure. In: Laragh JH, Brenner BM, editors. Hypertension: pathophysiology, diagnosis and management. New York: Raven Press; 1990. pp. 81-100.
10. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990; 86:1343-1346.
11. O'Donnell CJ, Lindpaintner K, Larson MG, Rao VS, Ordovas JM, Schaefer EJ, et al. Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not in women in the Framingham Heart Study. Circulation 1998; 97:1766-1772.
12. Bengtsson K, Orho-Melander M, Lindblad U, Melander O, Bög-Hansen E, Ranstam J, et al. Polymorphism in the angiotensin converting enzyme but not in the angiotensinogen gene is associated with hypertension and type 2 diabetes: the Skaraborg Hypertension and Diabetes Project. J Hypertens 1999; 17:1569-1575.
13. Keavney B, McKenzie C, Parish S, Palmer A, Clark S, Youngman L, et al. Large-scale test of hypothesised associations between the angiotensin-converting-enzyme insertion/deletion polymorphism and myocardial infarction in about 5000 cases and 6000 controls. Lancet 2000; 355:434-442.
14. Barcelo A, Elorza MA, Barbe F, Santos C, Mayoralas LR, Agusti AGN, et al. Angiotensin converting enzyme in patients with sleep apnoea syndrome: plasma activity and gene polymorphism. Eur Respir J 2001; 17:728-732.
15. Zhang J, Zhao B, Gesongluobu, Sun Y, Wu Y, Pei W, et al. Angiotensin-converting enzyme gene insertion/deletion (I/D) polymorphism in hypertensive patients with different degrees of obstructive sleep apnea. Hypertens Res 2000; 23:407-411.
16. Hedner J, Bengtsson Boström K, Peker Y, Grote L, Rastam L, Lindblad U. Hypertension prevalence in obstructive sleep apnoea and sex: a population-based case-control study. Eur Respir J 2006; 27:564-570.
17. Bog-Hansen E, Lindblad U, Bengtsson K, Ranstam J, Melander A, Rastam L. Risk factor clustering in patients with hypertension and NIDDM. The Skaraborg Hypertension Project. J Intern Med 1998; 243:223-232.
18. National Board of Health and Welfare, Drug Information Committee. Treatment of mild hypertension, vol. 1. Stockholm: National Board of Health and Welfare, Drug Information Committee; 1987.
19. Medical Products Agency. Treatment of hypertension in the elderly. Stockholm: Medical Products Agency; 1993.
20. Råstam L, Sjönell G. A new device for measuring blood pressure in adults. Lancet 1991; 337:249-250.
21. Sleep Medicine Task Force. Sleep-related breathing disorders in adults recommendations for syndrome definition and sleep measurement techniques in clinical research. The Report of an American Academy of Sleep Medicine Task Force. Sleep 1999; 22:667-689.
22. Rechtschaffen A, Kales A. A manual of standardized terminology: techniques and scoring system for sleep stages of human subjects. Los Angeles: UCLA Brain Information Service/Brain Research Institute; 1968.
23. Phillips C, Hedner J, Berend N, Grunstein R. Diurnal and obstructive sleep apnea influences on arterial stiffness and central blood pressure in men. Sleep 2005; 28:604-609.
24. Lin L, Finn L, Zhang J, Young T, Mignot E. Angiotensin-converting enzyme, sleep-disordered breathing, and hypertension. Am J Respir Crit Care Med 2004; 170:1349-1353.
25. Costerousse O, Allegrini J, Lopez M, Alhenc-Gelas F. Angiotensin I-converting enzyme in human circulating mononuclear cells: genetic polymorphism of expression in T-lymphocytes. Biochem J 1993; 290:33-40.
26. Rutledge DR, Kubilis P, Browe CS, Ross EA. Polymorphism of the angiotensin I converting enzyme gene in essential hypertensive patients. Biochem Mol Biol Int 1995; 35:661-668.
27. Yoshida K, Ishigami T, Nakazawa I, Ohno A, Tamura K, Fukuoka M, et al. Association of essential hypertension in elderly Japanese with I/D polymorphism of the angiotensin-converting enzyme (ACE) gene. J Hum Genet 2000; 45:294-298.
28. Barley J, Blackwood A, Miller M, Markandu ND, Carter ND, Jeffery S, et al. Angiotensin converting enzyme gene I/D polymorphism, blood pressure and the renin-angiotensin system in Caucasian and Afro-Caribbean peoples. J Hum Hypertens 1996; 10:31-35.