Polymorphism in the angiotensin converting enzyme but not in the angiotensinogen gene is associated with hypertension and type 2 diabetes: The Skaraborg Hypertension and Diabetes Project

Journal of Hypertension

Volumn 17, Issue 11, 1999, Pages 1569-1575

  Bengtsson, Kristina ^a,d   Orho Melander, Marju ^e   Lindblad, Ulf ^b   Melander, Olle ^e   Bøg Hansen, Erik ^a   Ranstam, Jonas ^c   Råstam, Lennart ^e   Groop, Leif ^e  

^a Skara Health Care Centre   (Sweden)

^b Skaraborgs Institutet   (Sweden)

^c Network for Pharmacoepidemiology Foundation   (Sweden)

^d Billingen Health Care Center   (Sweden)

^e NONE

Author keywords

Angiotensin converting enzyme gene; Angiotensinogen gene; Essential hypertension; Polymorphism; Type 2 diabetes

Indexed keywords

ANGIOTENSINOGEN; DIPEPTIDYL CARBOXYPEPTIDASE;

ADULT; AGE; AGED; ARTICLE; CONTROLLED STUDY; ESSENTIAL HYPERTENSION; GENE DELETION; GENE INSERTION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL;

EID: 0032729521     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-199917110-00010     Document Type: Article

References (44)

1. Kurtz TW, Spence MA. Genetics of essential hypertension. Am J Med 1993; 94:77-84.
2. Barnett AH, Spiliopoulos AJ, Pyke DA, Stubbs WA, Burrin J, Alberti KG. Metabolic studies in unaffected co-twins of non-insulin-dependent diabetics. Br Med J Clin Res Ed 1981; 282:1656-1658.
3. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990; 86:1343-1346.
4. Cambien F, Costerousse O, Tiret L, Poirier O, Lecerf L, et al. Plasma level and gene polymorphism of angiotensin-converting enzyme in relation to myocardial infarction. Circulation 1994; 90:669-676.
5. Keavney BD, Dudley CRK, Stratton IM, Holman RR, Mattews DR, Ratcliff PJ, et al. UK Prospective Diabetes Study (UKPDS) 14: association of angiotensin-converting enzyme insertion/deletion polymorphism with myocardial infarction in NIDDM. Diabetologia 1995; 38:948-952.
6. Ruiz J, Blanche H, Cohen N, Velho G, Cambion F, Cohen D, et al. Insertion/deletion polymorphism of the angiotensin-coverting enzyme gene is strongly associated with coronary heart disease in non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA 1994; 91:3662-3665.
7. Chan JC, Cheung CK, Cockram CS, Critchley JA, Swaminathan R, Law LK, et al. Atrial natriuretic peptide and renin-angiotensin-aldosteron system in non-insulin-dependent diabetes mellitus. J Hum Hypertens 1994; 8:451-456.
8. Jeunemaitre X, Lifton RP, Hunt SC, Williams RR, Lalouel J-M. Absence of linkage between the angiotensin converting enzyme locus and human essential hypertension. Nature Genet 1992; 1:72-75.
9. Harrap SB, Davidsson HR, Connor JM, Soubrier F, Corvol P, Fraser R, et al. The angiotensin I converting enzyme gene and predisposition to high blood pressure. Hypertension 1993; 21:455-460.
10. Schmidt S, van Hooft IMS, Grobbee DE, Ganten D, Ritz E. Polymorphism of the angiotensin I converting enzyme is apparently not related to high blood pressure: Dutch Hypertension and Offspring Study. J Hypertens 1993; 11:345-348.
11. Jeunemaitre X, Soubrier F, Kotelevtsev YV, Lifton RP, Williams CS, Charru A, et al. Molecular basis of human hypertension: role of angiotensinogen. Cell 1992; 71:169-180.
12. Hala A, Namikawa C, Sasaki M, Sato K, Nakamura T, Tamura K, et al. Angiotensinogen as a risk factor for essential hypertension in Japan. J Clin Invest 1994; 93:1285-1287.
13. Nishiuma S, Kario K, Kayaba K, Nagio N, Shimada K, Matsuo T, et al. Effect of the angiotensinogen gene Met 235 to Thr variant on blood pressure and other cardiovascular risk factors in two Japanese populations. J Hypertens 1995; 13:717-722.
14. Johnson AG, Simons LA, Friedlander Y, Simons J, Davies DR, MaCallum J. M235 to T polymorphism of the angiotensinogen gene predicts hypertension in the elderly. J Hypertens 1996; 14:1061-1065.
15. Schmidt S, Sharma AM, Zilch O, Beige J, Walla-Friedel M, Ganten D, et al. Association of M235T variant of the angiotensinogen gene with familial hypertension of early onset. Nephrol Dial Transplant 1995; 10:1145-1148.
16. Inoue I, Nakajima T, Williams CS, Quackenbush J, Puryear R, Powers M, et al. A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro. J Clin Invest 1997; 99:1786-1797.
17. Caulfield M, Lavender P, Farrrall M, Munroe P, Lawson M, Turner P, et al. Linkage of the angiotensinogen gene to essential hypertension. New Engl J Med 1994; 330:1629-1633.
18. Hingorani AD, Sharma P, Jia H, Hopper R, Brown MJ. Blood pressure and the M235T polymorphism of the angiotensinogen gene. Hypertension 1996; 28:907-911.
19. Fornage M, Turner ST, Sing CF, Boerwinkle E. Variation at the M235T locus of the angiotensinogen gene and essential hypertension: a population-based case-control study from Rochester, Minnesota. Hum Genet 1995; 96:295-300.
20. Ringel J, Beige J, Kunz R, Distler A, Sharma AM. Genetic variants of the renin-angiotensin system, diabetic nephropathy and hypertension. Diabetologia 1997; 40:193-199.
21. Barnes U, Schmidt A, Illievich A, Kiener HP, Rabenstiener D, Kaider A, et al. Evaluation of risk factors for the development of nephropathy in patients with IDDM: insertion/deletion angiotensin converting enzyme gene polymorphism, hypertension and metabolic control. Diabetologia 1997; 40:327-331.
22. Berglund G, Isacsson S-O, Rydén L. The Skaraborg Hypertension Project. A controlled trial regarding the effect of structured hypertension care. Acta Med Scand 1979; 205 (suppl 626):64-68.
23. Rǎstam L, Berglund G, Isacsson S-O, Rydén, L. The Skaraborg Hypertension Project. III. Influence on blood pressure of a medical care program for hypertension. Acta Med Scand 1986; 219:261-269.
24. National Board of Health and Welfare, Drug Information Committee. Treatment of mild hypertension. Vol. 1. Stockholm: National Board of Health and Welfare, Drug Information Committee; 1987.
25. Medical Products Agency. Treatment of hypertension in the elderly. Stockholm: Medical Products Agency; 1993.
26. WHO Study Group. Diabetes mellitus. Geneva: World Health Organization; 1985.
27. Bög-Hansen E, Lindblad U, Bengtsson K, Ranstam J, Melander A, Råstam L. Risk factor clustering in patients with hypertension and NIDDM. The Skaraborg Hypertension Project. J Int Med 1998; 243:223-232.
28. Sambrooks J, Fritsch EF, Maniatis T. Molecular cloning: a laboratory manual. 2nd edn. New York: Cold Spring Harbour; 1989.
29. Rigat B, Hubert C, Corvol P, Soubrier F. PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidas 1). Nucl Acids Res 1992; 20:1433.
30. Shanmugan V, Sell KW, Saha BK. Mistyping ACE heterozygotes. PCR Methods Appl 1993; 3:120-121.
31. Russ AP, Maerz W, Ruzicka V, Stein U, Gross W. Rapid detection of the hypertension associated Met235 to Thr allele of the human angiotensinogen gene. Hum Mol Genet 1993; 2:609-610.
32. Kotelevtsev YV, Clauser E, Corvol P, Soubrier F. Dinucleotide polymorphism in the human angiotensinogen gene. Nucl Acids Res 1991; 19:6978.
33. Barley J, Blackwood A, Miller M, Markandu ND, Carter ND, Jeffery S, et al. Angiotensin converting enzyme gene I/D polymorphism, blood pressure and the renin-angiotensin system in Caucasian and Afro-Caribbean peoples. J Hum Hypertens 1996; 10:31-35.
34. Cambien F, Poirier O, Lecerf L, Evans A, Cambou J-P, Arveiler D, et al. Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Nature 1992; 359:641-644.
35. Summers KM, West JA, Huggard PR, West MJ. Angiotensin-converting enzyme and regulation of blood pressure in a large Australian family. Clin Exp Pharmacol Physiol 1993; 20:320-323.
36. Lander E, Schork N, Genetic dissection of complex traits. Science 1994; 265:2037-2048.
37. Kiema T-R, Kauma H, Rantala AO, Lilja M, Reunanen A, Kesäniemi YA, et al. Variation at the angiotensin-converting enzyme gene and angiotensinogen gene loci in relation to blood pressure. Hypertension 1996; 28:1070-1075.
38. Asamoah A, Yanamandra K, Thurmon TF, Richter R, Green R, Lakin T, et al. A deletion in the angiotensin converting enzyme (ACE) gene is common among African Americans with essential hypertension. Clinica Chimica Acta 1996; 254:41-46.
39. Duru K, Farrow S, Wang J-M, Lockette W, Kurtz T. Frequency of a deletion polymorphism in the gene for angiotensin converting enzyme is increased in African-Americans with hypertension. Am J Hypertens 1994; 7:759-762.
40. Abbud ZA, Wilson AC, Cosgrove NM, Kostis JB. Angiotensin-converting enzyme gene polymorphism in systemic hypertension. Am J Cardiol 1998; 81:244-246.
41. Panahloo A, Andres C, Mohamed-Ali V, Gould MM, Talmud P, Humphries SE, Yudkin JS. The insertion allele of the ACE gene I/D polymorphism a candidate gene for insulin resistance? Circulation 1995; 92:3390-3393.
42. Chiu KC, McCarthy JE. The insertion allele at the angiotensin I-converting enzyme gene locus is associated with insulin resistance. Metabolism 1997; 46:395-399.
43. Cong ND, Hamaguchi K, Saikawa T, Hara M, Sakata T. The I/D polymorphism of the angiotensin-converting enzyme gene but not the angiotensinogen gene is associated with insulin response to oral glucose in Japanese. Proc Soc Expl Biol Med 1999; 220:46-51.
44. Kurtz R, Kreutz R, Beige J, Distler A, Sharma AM. Association between the angiotensinogen 235T-variant and essential hypertension in whites. Hypertension 1997; 30:1331-1337.