Estrogen and ghrelin decrease cytoplasmic expression of p27kip1, a cellular marker of ageing, in the striated anal sphincter and levator muscle of ovariectomized rats

International Urogynecology Journal

Volumn 18, Issue 4, 2007, Pages 413-418

  Rizk, Diaa E E ^a,b   Al Marzouqi, Ahmed H ^a   Hassan, Hazem A ^a   Al Kedrah, Soha S ^a   Fahim, Mohamed A ^a  

^a UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

^b NONE   (United Arab Emirates)

Author keywords

Ageing; Incontinence; Menopause; p27kip1; Rat

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1B; ESTRADIOL; GHRELIN; PLACEBO;

AGING; ANIMAL MODEL; ANIMAL TISSUE; ANUS SPHINCTER; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENTIATION; FEMALE; HORMONE SUBSTITUTION; LEVATOR ANI MUSCLE; MENOPAUSE; MONOTHERAPY; NONHUMAN; OVARIECTOMY; PELVIS FLOOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SKELETAL MUSCLE; URINE INCONTINENCE; WESTERN BLOTTING; WISTAR RAT;

EID: 33847797029     PISSN: 09373462     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00192-006-0159-x     Document Type: Article

References (25)

1. Tannenbaum C, Perrin L, Kuchel GA (2001) The aging pelvic floor. In: Crocos J, Schick E (eds) The urinary sphincter. Marcel Dekker, New York, pp 175-181
2. Plas E, Daha LK (2004) Hormone replacement therapy for the aging bladder. In: Plas E, Pfluger H, Maier, Hubner W (eds) The aging bladder. Springer, Berlin Heidelberg New York, pp 137-154
3. Wyman JF, Bliss DZ, Dougherty MC, Gray M, Kaas M, Newman DK et al (2004) Shaping future directions for incontinence research in aging adults: executive summary. Nurs Res 53(Suppl 1):S1-S10
4. Cayzergues L, El-Djouher Y, Tabard SB, Jestin A, Blanchard P, Giuliano F et al (2005) Morphological study of the spinal motoneurons controlling the urethral sphincter of female rats: Role of androgens in a menopausal model. J Urol 173:1022-1026
5. Tariq SH (2004) Geriatric fecal incontinence. Clin Geriatr Med 20:571-587
6. Cheetham MJ, Kenefick NJ, Kamm MA (2001) Non-surgical management of faecal incontinence. Br J Hosp Med 62:538-541
7. Hendrix SL, Cochrane BB, Nygaard IE, Handa VL, Barnabei VM, Iglesia C et al (2005) Effects of estrogen with and without progestin on urinary incontinence. JAMA 293:935-948
8. Moalli PA, Nancy S, Howden NS, Lowder JL, Navarro J, Debes KM et al (2005) A rat model to study the structural properties of the vagina and its supportive tissues. Am J Obstet Gynecol 192:80-88
9. Bukovsky A, Copas P, Caudle MR, Cekanova M, Dassanayake T, Asbury B et al (2004) Abnormal expression of p27kip1 protein in levator muscle of aging women with pelvic floor disorders - a relationship to the cellular differentiation and degeneration. BMC Clin Pathol 1:4
10. Fornell EU, Wingren G, Kjolhede P (2004) Factors associated with pelvic floor dysfunction with emphasis on urinary and fecal incontinence and genital prolapse: An epidemiologic study. Acta Obstet Gynecol Scand 83:383-389
11. Yiou R, Delmas V, Carmeliet P, Gherardi RK, Barlovatz-Meimon G, Chopin DK et al (2001) The pathophysiology of pelvic floor disorders: Evidence from a histometric study of the perineum and a mouse model of rectal prolapse. J Anat 199:599-607
12. Hall JE (2004) Neuroendocrine physiology of the early and late menopause. Endocrinol Metab Clin N Am 33:637-659
13. Constantinou CE, Hvistendahl G, Ryhammer A, Nagel LL, Djurhuus JC (2002) Determining the displacement of the pelvic floor and pelvic organs during voluntary contractions using magnetic resonance imaging in younger and older women. BJU Int 90:408-414
14. Jundt K, Kiening M, Fischer P, Bergauer F, Rauch E, Janni W et al (2005) Is the histomorphological concept of the female pelvic floor and its changes due to age and vaginal delivery correct? Neurourol Urodyn 24:44-50
15. Dimpfl T, Jaeger C, Mueller-Felber W, Anthuber C, Hirsch A, Brandmaier R et al (1998) Myogenic changes of the levator ani muscle in premenopausal women: The impact of vaginal delivery and age. Neurourol Urodyn 17:197-205
16. Steinauer JE, Waetjen LE, Vittinghoff E, Subak LL, Hulley SB, Grady D, for the Heart and Estrogen/Progestin Replacement Study Research Group et al (2005) Post-menopausal hormone therapy: Does it cause incontinence? Obstet Gynecol 106:940-945
17. Welle S, Brooks AI, Delehanty JM, Needler N, Bhatt K, Shakh B et al (2004) Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women. Exp Gerontol 39:368-377
18. Kellokoski E, Poykko SM, Karjalainen AH, Ukkola O, Heikkinen J, Kesaniemi YA et al (2005) Estrogen replacement therapy increases plasma ghrelin levels. J Clin Endocrinol Metab 90:2954-2963
19. Ghigo E, Broglio F, Arvat E, Maccario M, Papott M, Muccioli G (2005) Ghrelin: More than a natural GH secretagogue and/or an orexigenic factor. Clin Endocrinol 62:1-17
20. De Souza MJ, Leidy HJ, O'Donnell E, Lasley B, Williams NI (2004) Fasting ghrelin levels in physically active women: Relationship of menstrual disturbances and metabolic hormones. J Clin Endocrinol Metab 89:3536-3542
21. Russell B, Baumann M, Heidkamp MC, Svanborg A (1996) Morphometry of the aging female rat urethra. Int Urogynecol J 7:30-36
22. Souccar C, Goncalo MC, Buck HS, Lima-Landman MT, Lapa AJ (2005) Mild dystrophic damage in the androgen-sensitive levator ani muscle of the mdx mouse. Neuromuscul Disord 15:48-56
23. Nnodim JO (2000) Satellite cell numbers in senile rat levator ani muscle. Mech Ageing Dev 112:99-111
24. Rizk DEE, Hassan HA, Ramadan GA, Shafiullah M, Fahim MA (2005) Estrogen and ghrelin increase the number of submucosal urethral and anal canal blood vessels in ovariectomized rats. Urology 66:1343-1348
25. Wolf OT, Heinrich AB, Hanstein B, Kirschbaum C (2005) Estradiol or estradiol/progesterone in older women: No strong effect of cognition. Neurobiol Aging 26:1029-1033