Nonparametric extraction of transient changes in neurotransmitter concentration from dynamic PET data

IEEE Transactions on Medical Imaging

Volumn 26, Issue 3, 2007, Pages 359-373

  Constantinescu, Cristian C ^a,b   Bouman, Charles ^a,b,c   Morris, Evan D ^a,d  

^a IEEE   (United States)

^b PURDUE UNIVERSITY   (United States)

^c Indiana University Purdue University Indianapolis   (United States)

^d INDIANA UNIVERSITY   (United States)

Author keywords

Dopamine; Positron emission tomography; Singular value decomposition

Indexed keywords

DA SIGNALS; DOPAMINE; MINIMUM MEAN SQUARE ERRORS (MMSE); NEUROTRANSMITTERS;

BRAIN; COMPUTER SIMULATION; POSITRON EMISSION TOMOGRAPHY; SIGNAL PROCESSING; SINGULAR VALUE DECOMPOSITION; TISSUE;

DATA REDUCTION;

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ALCOHOL; DIAGNOSTIC AGENT; DOPAMINE; RACLOPRIDE; RADIOPHARMACEUTICAL AGENT;

ALGORITHM; ARTICLE; BIOLOGICAL MODEL; COMPUTER ASSISTED DIAGNOSIS; COMPUTER SIMULATION; DRUG EFFECT; HUMAN; METABOLIC CLEARANCE RATE; METABOLISM; METHODOLOGY; NUCLEUS ACCUMBENS; POSITRON EMISSION TOMOGRAPHY; TISSUE DISTRIBUTION;

ALGORITHMS; COMPUTER SIMULATION; DOPAMINE; ETHANOL; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; METABOLIC CLEARANCE RATE; MODELS, NEUROLOGICAL; NEUROTRANSMITTER AGENTS; NUCLEUS ACCUMBENS; POSITRON-EMISSION TOMOGRAPHY; RACLOPRIDE; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION;

EID: 33847791056     PISSN: 02780062     EISSN: None     Source Type: Journal    
DOI: 10.1109/TMI.2006.891501     Document Type: Article

References (44)

1. E. D. Morris, R. E. Fisher, N. M. Alpert, S. L. Rauch, and A. J. Fischman, "In vivo imaging of neuromodulation using positron emission tomography: optimal ligand characteristics and task length for detection of activation," Hum. Brain Mapp., no. 3, pp. 35-55, 1995.
2. R. E. Fisher, E. D. Morris, N. M. Alpert, and A. J. Fischman, "In vivo imaging of neuromodulatory synaptic transmission using PET: A review of relevant neurophysiology," Hum. Brain Mapp., no. 3, pp. 24-34, 1995.
3. M. Lamelle, R. N. Iyer, M. S. al Tikriti, Y. Zea-Ponce, R. Malison, S. S. Zoghbi, R. M. Baldwin, H. F. Kung, D. S. Charney, P. B. Hoffer, R. B. Innis, and C. W. Bradberry, "Microdialysis and SPECT measurements of amphetamine-induced dopamine release in nonhuman primates," Synapse, vol. 25, no. 1, pp. 1-14, Jan. 1997.
4. R. E. Carson, A. Breier, A. de Bartolomeis, R. C. Saunders, T. P. Su, B. Schmall, M. G. Der, D. Pickar, and W. C. Eckelman, "Quantification of amphetamine-induced changes in [11C]raclopride binding with continuous infusion," J. Cereb. Blood Flow Metab., vol. 17, no. 4, pp. 437-447, Apr. 1997.
5. M. J. Koepp, R. N. Gunn, A. D. Lawrence, V. J. Cunningham, A. Dagher, T. Jones, D. J. Brooks, C. J. Bench, and P. M. Grasby, "Evidence for striatal dopamine release during a video game," Nature, vol. 393, no. 6682, pp. 266-268, May 1998.
6. S. Pappata, Dehaene, J. B. Poline, M. C. Gregoire, A. Jobert, J. Delforge, V. Frouin, M. Bottlaender, F. Dolle, L. Di Giamberardino, and A. Syrota, "In vivo detection of striatal dopamine release during reward: A PET study with [(11)C]raclopride and a single dynamic scan approach," Neuroimage, vol. 16, no. 4, pp. 1015-1027, Aug. 2002.
7. R. D. Badgaiyan, A. J. Fischman, and N. M. Alpert, "Striatal dopamine release during unrewarded motor task in human volunteers," Neuroreport, vol. 14, no. 11, pp. 1421-1424, Aug. 2003.
8. A. Breier, T. P. Su, R. Saunders, R. E. Carson, B. S. Kolachana, A. de Bartolomeis, D. R. Weinberger, N. Weisenfeld, A. K. Malhotra, W. C. Eckelman, and D. Pickar, "Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method," Proc. Natl. Acad. Sci. USA, vol. 94, no. 6, pp. 2569-2574, Mar. 1997.
9. N. Ginovart, L. Farde, C. Halldin, and C. G. Swahn, "Effect of reserpine-induced depletion of synaptic dopamine on [11C]raclopride binding to D2-dopamine receptors in the monkey brain," Synapse, vol. 25, no. 4, pp. 321-325, Apr. 1997.
10. K. K. Yoder, C. Wang, and E. D. Morris, "Change in binding potential as a quantitative index of neurotransmitter release is highly sensitive to relative timing and kinetics of the tracer and the endogenous ligand," J. Nucl. Med., vol. 45, no. 5, pp. 903-911, May 2004.
11. C. J. Endres, B. S. Kolachana, R. C. Saunders, T. Su, D. Weinberger, A. Breier, W. C. Eckelman, and R. E. Carson, "Kinetic modeling of [11C]raclopride: Combined PET-microdialysis studies," J. Cereb. Blood Flow Metab., vol. 17, no. 9, pp. 932-942, Sep. 1997.
12. C. J. Endres and R. E. Carson, "Assessment of dynamic neurotransmitter changes with bolus or infusion delivery of neuroreceptor ligands," J. Cereb. Blood Flow Metab., vol. 18, no. 11, pp. 1196-1210, Nov. 1998.
13. K. J. Friston, A. L. Malizia, S. Wilson, V. J. Cunningham, T. Jones, and D. J. Nutt, "Analysis of dynamic radioligand displacement or "activation" studies," J. Cereb. Blood Flow Metab., vol. 17, no. 1, pp. 80-93, Jan. 1997.
14. R. N. Gunn, A. A. Lammertsma, S. P. Hume, R. Myers, P. M. Bloomfield, and V. J. Cunningham, "A simplified reference region approach to parametric imaging of ligand receptor binding in PET," J. Nucl. Med., vol. 38, no. 5, p. 875, May 1997.
15. N. M. Alpert, R. D. Badgaiyan, E. Livni, and A. J. Fischman, "A novel method for noninvabsive detection of neuromodulatory changes in specific neurotransmitter systems," Neuroimage, vol. 19, no. 3, pp. 1049-1060, July 2003.
16. A. A. Grace, "The tonic/phasic model of dopamine system regulation and its implications for understanding alcohol and psychostimulant craving," Addiction, vol. 95, pp. S119-S128, Aug. 2000.
17. N. D. Volkow, Y. S. Ding, J. S. Fowler, G. J. Wang, J. Logan, J. S. Gatley, S. Dewey, C. Ashby, J. Liebermann, and R. Hitzemann, "Is methylphenidate like cocaine? Studies on their pharmacokinetics and distribution in the human brain," Arch. Gen. Psych., vol. 52, no. 6, pp. 456-463, Jun. 1995.
18. N. D. Volkow and J. M. Swanson, "Variables that affect the clinical use and abuse of methylphenidate in the treatment of ADHD," Amer. J Psych., vol. 160, no. 11, pp. 1909-1918, Nov. 2003.
19. E. D. Morris, K. K. Yoder, C. Wang, M. D. Normandin, Q. H. Zheng, B. Mock, R. F. Muzic, Jr., and J. C. Froehlich, "ntPET: A new application of PET imaging for characterizing the kinetics of endogenous neurotransmitter release," Mol. Imag., vol. 4, no. 4, pp. 473-489, Oct. 2005.
20. G. H. Golub and C. F. Van Loan, Matrix Computation, 3rd ed. Baltimore, MD: Johns Hopkins Univ. Press, 1996.
21. K. J. Friston, C. D. Frith, P. F. Liddle, and R. S. J. Frackowiak, "Functional connectivity - the principal-component analysis of large (pet) data sets," J. Cereb. Blood Flow Metabol., vol. 13, no. 1, pp. 5-14, Jan. 1993.
22. K. J. Worsley, "An overview and some new developments in the statistical analysis of PET and fMRI data," Hum. Brain Mapp., vol. 5, no. 4, pp. 254-258, 1997.
23. K. J. Friston, J. B. Poline, A. P. Holmes, C. D. Frith, and R. S. J. Frackowiak, "A multivariate analysis of PET activation studies," Hum. Brain Mapp., vol. 4, no. 2, pp. 140-151, 1996.
24. A. H. Andersen, D. M. Gash, and M. J. Avison, "Principal component analysis of the dynamic response measured by fMRI: A generalized linear systems framework," Magn. Resonan. Imag., vol. 17, no. 6, pp. 795-815, Jul. 1999.
25. C. W. Bradberry, "Acute and chronic dopamine dynamics in a nonhuman primate model of recreational cocaine use," J. Neurosci., vol. 20, no. 18, pp. 7109-7115, Sep. 2000.
26. H. Tsukada, N. Harada, S. Nishiyama, H. Ohba, and T. Kakiuchi, "Dose-response and duration effects of acute administrations of cocaine and GBR 12909 on dopamine synthesis and transporter in the conscious monkey brain: PET studies combined with microdialysis," Brain Res., vol. 860, no. 1-2, pp. 141-148, Mar. 2000.
27. K. Yoshimoto, W. J. McBride, L. Lumeng, and T. K. Li, "Alcohol stimulates the release of dopamine and serotonin in the nucleus accumbens," Aleohol, vol. 9, no. 1, pp. 17-22, Jan. 1992.
28. K. K. Yoder, D. A. Kareken, R. A. Seyoum, S. J. O'Connor, C. Wang, Q. H. Zheng, B. Mock, and E. D. Morris, "Dopamine D(2) receptor availability is associated with subjective responses to alcohol," Alcohol Clin. Exp. Res., vol. 29, no. 6, pp. 965-970, June 2005.
29. S. O'Connor, S. Morzorati, J. Christian, and T. K. Li, "Clamping breath alcohol concentration reduces experimental variance: Application to the study of acute tolerance to alcohol and alcohol elimination rate," Alcohol Clin. Exp. Res., vol. 22, no. 1, pp. 202-210, Feb. 1998.
30. D. A. Kareken, E. D. Claus, M. Sabri, M. Dzemidzic, A. E. Kosobud, A. J. Radnovich, D. Hector, V. A. Ramchandani, S. J. O'Connor, M. Lowe, and T. K. Li, "Alcohol-related olfactory cues activate the nucleus accumbens and ventral tegmental area in high-risk drinkers: preliminary findings," Alcohol Clin. Exp. Res., vol. 28, no. 4, pp. 550-557, Apr. 2004.
31. C. Heidbreder and P. De Witte, "Ethanol differentially affects extracellular monoamines and GABA in the nucleus accumbens," Pharmacol. Biochem. Behav., vol. 46, no. 2, pp. 477-481, Oct. 1993.
32. I. Boileau, J. M. Assaad, R. O. Pihl, C. Benkelfat, M. Leyton, M. Diksic, R. E. Tremblay, and A. Dagher, "Alcohol promotes dopamine release in the human nucleus accumbens," Synapse, vol. 49, no. 4, pp. 226-231, Sep. 2003.
33. J. Jackson, A Users Guide to Principal Components. New York: Wiley, 1991.
34. N. Wiener, Extrapolation, Interpolation and Smoothing of Stationary Time Series With Engineering Applications. New York: Wiley, 1949.
35. D. P. Berrar, W. Dubitzky, and M. Granzow, "Singular value decomposition and principal component analysis," in A Practical Approach to Microarray Data Analysis. Boston, MA: Kluwer Academic, 2003, pp. 91-109.
36. M. D. Normandin and E. D. Morris, "Temporal resolution of ntPET using either arterial or reference region-derived plasma input functions," in Proc. 28th Annu. IEEE Conf. Eng. Med. Biol., New York, 2006, pp. 2005-2008.
37. L. Farde, L. Eriksson, G. Blomquist, and C. Halldin, "Kinetic analysis of central [11C]raclopride binding to D2-dopamine receptors studied by PET - A comparison to the equilibrium analysis," J. Cereb. Blood Flow Metab., vol. 9, no. 5, pp. 696-708, Oct. 1989.
38. B. Johnson, L. Lamki, B. Fang, B. Barron, L. Wagner, L. Wells, P. Kenny, D. Overton, S. Dhother, D. Abramson, R. Chen, and L. Kramer, "Demonstration of dose-dependent global and regional cocaine-induced reductions in brain blood flow using a novel approach to quantitative single photon emission computerized tomography," Neuropsychopharmacology, vol. 18, no. 5, pp. 377-384, May 1998.
39. E. A. Wallace, G. Wisniewski, G. Zubal, C. H. vanDyck, S. E. Pfau, E. O. Smith, M. I. Rosen, M. C. Sullivan, S. W. Woods, and T. R. Kosten, "Acute cocaine effects on absolute cerebral blood flow," Psychopharmacology (Berl), vol. 128, no. 1, pp. 17-20, Nov. 1996.
40. N. D. Volkow, N. Mullani, L. Gould, S. S. Adler, R. W. Guynn, J. E. Overall, and S. Dewey, "Effects of acute alcohol intoxication on cerebral blood flow measured with PET," Psych. Res., vol. 24, no. 2, pp. 201-209, May 1988.
41. A. Dagher, R. Gunn, G. Lockwood, V. J. Cunningham, and P. M. Grasby, R. Carson, M. Daube-Witherspoon, and P. Herscovitch, Eds., "Measuring neurotransmitter release with Positron Emission Tomography: Methodological issues," in Quantitative Functional Brain Imaging with Positron Emission Tomography. San Diego, CA: Academic, 1998, pp. 449-454.
42. R. F. Muzic, Jr. and S. Cornelius, "COMKAT: compartment model kinetic analysis tool," J. Nucl. Med., vol. 42, no. 4, pp. 636-645, Apr. 2001.
43. C. C. Peck, S. L. Beal, L. B. Sheiner, and A. I. Nicholas, "Extended least squares nonlinear regression: A possible solution to the "choice of weights" problem in analysis of individual pharmacokinetic data," J. Pharmacokinet Biopharm., no. 12, pp. 545-548, 1984.
44. R. F. Muzic, Jr. and B. T. Christian, "Evaluation of objective functions for estimation of kinetic parameters," Med. Phys., vol. 33, no. 2, pp. 342-353, Feb. 2006.