Simple preparative isolation of salvinorin a from the hallucinogenic sage, salvia divinorum, by centrifugal partition chromatography

Journal of Liquid Chromatography and Related Technologies

Volumn 30, Issue 8, 2007, Pages 1105-1114

  Shirota, Osamu ^a   Nagamatsu, Kumi ^a   Sekita, Setsuko ^a  

^a TOKUSHIMA BUNRI UNIVERSITY   (Japan)

Author keywords

Centrifugal partition chromatography; CPC; Hallucinogenic sage; Neo clerodane diterpene; Salvia divinorum; Salvinorin A

Indexed keywords

CENTRIFUGATION; CHROMATOGRAPHIC ANALYSIS; METHANOL; PLANTS (BOTANY); RECRYSTALLIZATION (METALLURGY); SILICA GEL;

CENTRIFUGAL PARTITION CHROMATOGRAPHY (CPC); HALLUCINOGENIC SAGE; NEO-CLERODANE DITERPENE; SALVIA DIVINORUM; SALVINORIN A;

PROTEINS;

DICHLOROMETHANE; HEXANE; METHANOL; SALVINORIN A; SILICON DIOXIDE; SOLVENT;

ARTICLE; CRYSTALLIZATION; DRUG ISOLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PARTITION CHROMATOGRAPHY; PHASE SEPARATION; SALVIA; SEPARATION TECHNIQUE;

SALVIA DIVINORUM;

EID: 33847776234     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826070601128477     Document Type: Article

References (6)

1. Valdes, L.J., III; Butler, W.M.; Hatfield, G.M.; Paul, A.G.; Koreeda, M. Divinorin A, a psychotropic terpenoid, and divinorin B from the hallucinogenic Mexican mint, Salvia divinorum. J. Org. Chem. 1984, 49 (24), 4716-4720.
2. Ortega, A.; Blount, J.F.; Manchand, P.S. Salvinorin, a new trans-neoclerodane diterpene from Salvia divinorum (Labiatae). J. Chem. Soc. Perkin Trans. 1982, 1 (10), 2505-2508.
3. Giroud, C.; Felber, F.; Augsburger, M.; Horisberger, B.; Rivier, L.; Mangin, P. Salvia divinorum: an hallucinogenic mint which might become a new recreational drug in Switzerland. Foren. Sci. Int. 2000, 112 (2-3), 143-150.
4. Sheffler, D.J; Roth, B.L. Salvinorin A: the 'magic mint' hallucinogen finds a molecular target in the kappa opioid receptor. Trends Pharmacol. Sci. 2003, 24 (3), 107-109.
5. Munro, T.A.; Rizzacasa, M.A. Salvinorins D.-F., New neoclerodane diterpenoids from Salvia divinorum, and an improved method for the isolation of Salvinorin A. J. Nat. Prod. 2003, 66 (5), 703-705.
6. Marchal, L.; Legrand, J.; Foucault, A. Centrifugal partition chromatography: A survey of its history, and our recent advances in the field. Chem. Rec. 2003, 3 (3), 133-143.