Amlodipine bioequivalence achieved with a very sensitive liquid chromatography tandem mass spectrometric bioassay;Untersuchung der bioaquivalenz von amlodipin mit einem hochempfindlichen Flussigkeitschromatographie-tandem-massenspektrometrie-bioassay

Arzneimittel-Forschung/Drug Research

Volumn 50, Issue 8, 2000, Pages 688-694

  Marzo, A ^a   Dal Bo, L ^a   Mazzucchelli, P ^a   Ceppi Monti, N ^a   Crivelli, F ^a   Ismaili, S ^a   Uhr, M R ^a   La Commare, P ^a  

^a Institute for Pharmacokinetic and Analytical Studies SA   (Switzerland)

Author keywords

Amlodipine; Bioequivalence; CAS 12009268 4; CAS 88150 42 9; Manidipine; Pharmacokinetics

Indexed keywords

AMLODIPINE; MANIDIPINE;

ADULT; ARTICLE; BIOEQUIVALENCE; CAPSULE FILLING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG FORMULATION; DRUG HALF LIFE; DRUG SAFETY; ESSENTIAL HYPERTENSION; FEMALE; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; MALE; PHASE 3 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL; TABLET; TANDEM MASS SPECTROMETRY;

EID: 0033831370     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1300274     Document Type: Article

References (22)

1. Clinical pharmacokinetics of amlodipine
2. Amlodipine: A review of its pharmacodynamic and therapeutic use in cardiovascular disease
3. Amlodipine: A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease
4. Pharmacokinetic analysis, bioavailability and operating guidelines
5. Clinical pharmacokinetic registration file for NDA and ANDA procedures
6. Acceptable and unacceptable procedures in bioavailability and bioequivalence trials
7. Open questions on bioequivalence: Some problems and some solutions
8. High-performance liquid chromatography of nifedipine, its metabolites and photochemical degradation products
9. Swiss regulations for controlling clinical trials
10. Disposition of intravenous and oral cyclosporine after administration with grapefruit juice
11. Plasma concentrations of triazolam are increased by concomitant ingestion of grapefruit juice
12. Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid
13. Drug interactions with grapefruit juice
14. Grapefruit juice-drug interactions
15. Effect of grapefruit juice on the pharmacokinetics of amlodipine in healthy volunteers
16. Interaction of citrus juices with pranidipine, a new 1,4-dihydropyridine calcium antagonist, in healthy subjects
17. The bioequivalence: An updated reappraisal addressed to applications of interchangeable multi-source pharmaceutical products
18. A comparison of the two onesided tests procedure and the power approach for assessing the equivalence of average bioavailability
19. Analytical methods validation: Bioavailability, bioequivalence and pharmacokinetic studies
20. Quantitative determination of amlodipine in serum by liquid chromatography with atmosphere pressure chemical ionisation tandem mass spectrometry