-
1
-
-
12244275009
-
GLP-1 receptor agonists and DPP-4 inhibitors in the treatment of type 2 diabetes
-
Ahren B, Schmitz O. GLP-1 receptor agonists and DPP-4 inhibitors in the treatment of type 2 diabetes. Horm Metab Res 2004; 36 (11-12):867-876.
-
(2004)
Horm Metab Res
, vol.36
, Issue.11-12
, pp. 867-876
-
-
Ahren, B.1
Schmitz, O.2
-
2
-
-
30944467225
-
-
Schirra J, Nicolaus M, Roggel R, et al. Endogenous glucagon-like peptide 1 controls endocrine pancreatic secretion and antro-pyloro-duodenal motility in humans. Gut 2006; 55:243-251. This paper reveals the physiologic effects of GLP-1 on glucose metabolism in humans. Here it was demonstrated for the first time that endogenous GLP-1 is a physiologic incretin in humans and plays an important role in postprandial antropyloro-duodenal motility.
-
Schirra J, Nicolaus M, Roggel R, et al. Endogenous glucagon-like peptide 1 controls endocrine pancreatic secretion and antro-pyloro-duodenal motility in humans. Gut 2006; 55:243-251. This paper reveals the physiologic effects of GLP-1 on glucose metabolism in humans. Here it was demonstrated for the first time that endogenous GLP-1 is a physiologic incretin in humans and plays an important role in postprandial antropyloro-duodenal motility.
-
-
-
-
4
-
-
33644618433
-
-
Drucker DJ. The biology of incretin hormones. Cell Metab 2006; 3:153-165. This is an excellent and comprehensive review of incretin biology. It outlines all important findings that contribute to the current understanding of incretin biology and discusses up-to-date publications on GLP-1 signaling and its effects beyond being an incretin.
-
Drucker DJ. The biology of incretin hormones. Cell Metab 2006; 3:153-165. This is an excellent and comprehensive review of incretin biology. It outlines all important findings that contribute to the current understanding of incretin biology and discusses up-to-date publications on GLP-1 signaling and its effects beyond being an incretin.
-
-
-
-
5
-
-
0026510891
-
-
Eissele R, Goke R, Willemer S, et al. Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pigandman. Eur J Clin Invest1992; 22:283-291.
-
Eissele R, Goke R, Willemer S, et al. Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pigandman. Eur J Clin Invest1992; 22:283-291.
-
-
-
-
6
-
-
0030031146
-
Gastric emptying and release of incretin hormones after glucose ingestion in humans
-
Schirra J, Katschinski M, Weidmann C, et al. Gastric emptying and release of incretin hormones after glucose ingestion in humans. J Clin Invest 1996; 97:92-103.
-
(1996)
J Clin Invest
, vol.97
, pp. 92-103
-
-
Schirra, J.1
Katschinski, M.2
Weidmann, C.3
-
7
-
-
0028838030
-
Glucagon-like peptide-1 and glucose-dependent insulin-releasing polypeptide plasma levels in response to nutrients
-
Herrmann C, Goke R, Richter G, et al. Glucagon-like peptide-1 and glucose-dependent insulin-releasing polypeptide plasma levels in response to nutrients. Digestion 1995; 56:117-126.
-
(1995)
Digestion
, vol.56
, pp. 117-126
-
-
Herrmann, C.1
Goke, R.2
Richter, G.3
-
8
-
-
12244271085
-
Nutrient, neural and endocrine control of glucagon-like peptide secretion
-
Dube PE, Brubaker PL. Nutrient, neural and endocrine control of glucagon-like peptide secretion. Horm Metab Res 2004; 36 (11-12):755-760.
-
(2004)
Horm Metab Res
, vol.36
, Issue.11-12
, pp. 755-760
-
-
Dube, P.E.1
Brubaker, P.L.2
-
9
-
-
30144444692
-
Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters
-
This publication systematically analyzes the changes in gut hormone profiles after diverse techniques of bariatric surgery and reflects on their contribution to the observed weight loss
-
Le Roux CW, Aylwin SJ, Batterham RL, et al. Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters. Ann Surg 2006; 243:108-114. This publication systematically analyzes the changes in gut hormone profiles after diverse techniques of bariatric surgery and reflects on their contribution to the observed weight loss.
-
(2006)
Ann Surg
, vol.243
, pp. 108-114
-
-
Le Roux, C.W.1
Aylwin, S.J.2
Batterham, R.L.3
-
10
-
-
0842303191
-
The early effect of the Roux-en-Y gastric bypass on hormones involved in body weight regulation and glucose metabolism
-
Rubino F, Gagner M, Gentileschi P, et al. The early effect of the Roux-en-Y gastric bypass on hormones involved in body weight regulation and glucose metabolism. Ann Surg 2004; 240:236-242.
-
(2004)
Ann Surg
, vol.240
, pp. 236-242
-
-
Rubino, F.1
Gagner, M.2
Gentileschi, P.3
-
11
-
-
0019413107
-
Control of body weight by lower gut signals
-
Koopmans HS, Sclafani A. Control of body weight by lower gut signals. Int J Obes 1981; 5:491-495.
-
(1981)
Int J Obes
, vol.5
, pp. 491-495
-
-
Koopmans, H.S.1
Sclafani, A.2
-
12
-
-
12144258579
-
-
Strader AD, Vahl TP, Jandacek RJ, et al. Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats. Am J Physiol Endocrinol Metab 2005; 288:E447-E453. This work shows for the first time that GLP-1 and PYY at least partially mediate the previously established effects of ileal transposition surgery on food intake and body weight.
-
Strader AD, Vahl TP, Jandacek RJ, et al. Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats. Am J Physiol Endocrinol Metab 2005; 288:E447-E453. This work shows for the first time that GLP-1 and PYY at least partially mediate the previously established effects of ileal transposition surgery on food intake and body weight.
-
-
-
-
13
-
-
12244281855
-
Circulation and degradation of GIP and GLP-1
-
Deacon CF. Circulation and degradation of GIP and GLP-1. Horm Metab Res 2004; 36 (11-12):761-765.
-
(2004)
Horm Metab Res
, vol.36
, Issue.11-12
, pp. 761-765
-
-
Deacon, C.F.1
-
14
-
-
33744945766
-
-
Meier JJ, Gethmann A, Nauck MA, et al. The glucagon-like peptide-1 metabolite GLP-1-(9-36) amide reduces postprandial glycemia independently of gastric emptying and insulin secretion in humans. Am J Physiol Endocrinol Metab 2006; 290:E1118-E1123. This recent study rejuvenates the controversy over the biological effects of the degraded major metabolite GLP-1(9-36).
-
Meier JJ, Gethmann A, Nauck MA, et al. The glucagon-like peptide-1 metabolite GLP-1-(9-36) amide reduces postprandial glycemia independently of gastric emptying and insulin secretion in humans. Am J Physiol Endocrinol Metab 2006; 290:E1118-E1123. This recent study rejuvenates the controversy over the biological effects of the degraded major metabolite GLP-1(9-36).
-
-
-
-
15
-
-
0036081143
-
GLP-1-(9-36) amide reduces blood glucose in anesthetized pigs by a mechanism that does not involve insulin secretion
-
Deacon CF, Plamboeck A, Moller S, Holst JJ. GLP-1-(9-36) amide reduces blood glucose in anesthetized pigs by a mechanism that does not involve insulin secretion. Am J Physiol Endocrinol Metab 2002; 282:E873-E879.
-
(2002)
Am J Physiol Endocrinol Metab
, vol.282
-
-
Deacon, C.F.1
Plamboeck, A.2
Moller, S.3
Holst, J.J.4
-
16
-
-
0038359686
-
Effects of GLP-1-(7-36)NH2, GLP-1-(7-37), and GLP-1-(9-36)NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humans
-
Vahl TP, Paty BW, Fuller BD, et al. Effects of GLP-1-(7-36)NH2, GLP-1-(7-37), and GLP-1-(9-36)NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humans. J Clin Endocrinol Metab 2003; 88:1772-1779.
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 1772-1779
-
-
Vahl, T.P.1
Paty, B.W.2
Fuller, B.D.3
-
17
-
-
31844433106
-
-
Zander M, Madsbad S, Deacon CF, Holst JJ. The metabolite generated by dipeptidyl-peptidase 4 metabolism of glucagon-like peptide-1 has no influence on plasma glucose levels in patients with type 2 diabetes. Diabetologia 2006; 49:369-374. The findings of this study, which demonstrate a lack of effects of endogenous GLP-1(9-36) on glucose metabolism in patients with diabetes, are highly relevant in the light of DPP-IV inhibition as a drug target.
-
Zander M, Madsbad S, Deacon CF, Holst JJ. The metabolite generated by dipeptidyl-peptidase 4 metabolism of glucagon-like peptide-1 has no influence on plasma glucose levels in patients with type 2 diabetes. Diabetologia 2006; 49:369-374. The findings of this study, which demonstrate a lack of effects of endogenous GLP-1(9-36) on glucose metabolism in patients with diabetes, are highly relevant in the light of DPP-IV inhibition as a drug target.
-
-
-
-
18
-
-
0031029936
-
Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem
-
Larsen PJ, Tang-Christensen M, Holst JJ, Orskov C. Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem. Neuroscience 1997; 77:257-270.
-
(1997)
Neuroscience
, vol.77
, pp. 257-270
-
-
Larsen, P.J.1
Tang-Christensen, M.2
Holst, J.J.3
Orskov, C.4
-
19
-
-
13344282056
-
A role for glucagon-like peptide-1 in the central regulation of feeding
-
Turton MD, O'Shea D, Gunn I, et al. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 1996; 379:69-72.
-
(1996)
Nature
, vol.379
, pp. 69-72
-
-
Turton, M.D.1
O'Shea, D.2
Gunn, I.3
-
20
-
-
0029859220
-
Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats
-
Tang-Christensen M, Larsen PJ, Goke R, et al. Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats. Am J Physiol Regul Integr Comp Physiol 1996; 271 (4 Pt 2):R848-R856.
-
(1996)
Am J Physiol Regul Integr Comp Physiol
, vol.271
, Issue.4 PART 2
-
-
Tang-Christensen, M.1
Larsen, P.J.2
Goke, R.3
-
21
-
-
0030944526
-
Central infusion of GLP-1, but not leptin, produces conditioned taste aversions in rats
-
Thiele TE, Van Dijk G, Campfield LA, et al. Central infusion of GLP-1, but not leptin, produces conditioned taste aversions in rats. Am J Physiol Regul Integr Comp Physiol 1997; 272 (2 Pt 2):R726-R730.
-
(1997)
Am J Physiol Regul Integr Comp Physiol
, vol.272
, Issue.2 PART 2
-
-
Thiele, T.E.1
Van Dijk, G.2
Campfield, L.A.3
-
22
-
-
0032763050
-
A functional role for central glucagon-like peptide-1 receptors in lithium chloride-induced anorexia
-
Rinaman L. A functional role for central glucagon-like peptide-1 receptors in lithium chloride-induced anorexia. Am J Physiol Regul Integr Comp Physiol 1999; 277 (5 Pt 2):R1537-R1540.
-
(1999)
Am J Physiol Regul Integr Comp Physiol
, vol.277
, Issue.5 PART 2
-
-
Rinaman, L.1
-
23
-
-
0034652302
-
The role of CNS glucagon-like peptide-1 (7-36) amide receptors in mediating the visceral illness effects of lithium chloride
-
Seeley RJ, Blake K, Rushing PA, et al. The role of CNS glucagon-like peptide-1 (7-36) amide receptors in mediating the visceral illness effects of lithium chloride. J Neurosci 2000; 20:1616-1621.
-
(2000)
J Neurosci
, vol.20
, pp. 1616-1621
-
-
Seeley, R.J.1
Blake, K.2
Rushing, P.A.3
-
24
-
-
0036896243
-
The diverse roles of specific GLP-1 receptors in the control of food intake and the response to visceral illness
-
Kinzig KP, D'Alessio DA, Seeley RJ. The diverse roles of specific GLP-1 receptors in the control of food intake and the response to visceral illness. J Neurosci 2002; 22:10470-10476.
-
(2002)
J Neurosci
, vol.22
, pp. 10470-10476
-
-
Kinzig, K.P.1
D'Alessio, D.A.2
Seeley, R.J.3
-
25
-
-
11144244302
-
-
Lachey JL, D'Alessio DA, Rinaman L, et al. The role of central glucagon-like peptide-1 in mediating the effects of visceral illness: differential effects in rats and mice. Endocrinology 2005; 146:458-462. This study underlines the importance of species differences in animal models and points to the limits of transgenic mouse models to determine universal mammalian (GLP-1) physiology.
-
Lachey JL, D'Alessio DA, Rinaman L, et al. The role of central glucagon-like peptide-1 in mediating the effects of visceral illness: differential effects in rats and mice. Endocrinology 2005; 146:458-462. This study underlines the importance of species differences in animal models and points to the limits of transgenic mouse models to determine universal mammalian (GLP-1) physiology.
-
-
-
-
26
-
-
0033696456
-
-
Balkan B, Li X. Portal GLP-1 administration in rats augments the insulin response to glucose via neuronal mechanisms. Am J Physiol Regul Integr Comp Physiol 2000; 279:R1449-R1454.
-
Balkan B, Li X. Portal GLP-1 administration in rats augments the insulin response to glucose via neuronal mechanisms. Am J Physiol Regul Integr Comp Physiol 2000; 279:R1449-R1454.
-
-
-
-
27
-
-
0035434115
-
Glucose competence of the hepatoportal vein sensor requires the presence of an activated glucagon-like peptide-1 receptor
-
Burcelin R, Da Costa A, Drucker D, Thorens B. Glucose competence of the hepatoportal vein sensor requires the presence of an activated glucagon-like peptide-1 receptor. Diabetes 2001; 50:1720-1728.
-
(2001)
Diabetes
, vol.50
, pp. 1720-1728
-
-
Burcelin, R.1
Da Costa, A.2
Drucker, D.3
Thorens, B.4
-
28
-
-
33749260889
-
-
Ionut V, Liberty IF, Hucking K, et al. Exogenously imposed postprandial-like rises in systemic glucose and GLP-1 do not produce an incretin effect, suggesting an indirect mechanism of GLP-1 action. Am J Physiol Endocrinol Metab 2006; 291:E779-E785. This paper raises interesting questions about how GLP-1 physiologically mediates its incretin effects.
-
Ionut V, Liberty IF, Hucking K, et al. Exogenously imposed postprandial-like rises in systemic glucose and GLP-1 do not produce an incretin effect, suggesting an indirect mechanism of GLP-1 action. Am J Physiol Endocrinol Metab 2006; 291:E779-E785. This paper raises interesting questions about how GLP-1 physiologically mediates its incretin effects.
-
-
-
-
29
-
-
31044456099
-
-
Knauf C, Cani PD, Perrin C, et al. Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage. J Clin Invest 2005; 115:3554-3563. In this comprehensive study investigating the role of GLP-1 in the CNS, it has been shown for the first time that central GLP-1 controls peripheral glucose utilization. These findings illustrate the novel mechanisms by which GLP-1 contributes to glucose homeostasis and underline how peripheral and CNS physiology are integrated in GLP-1 physiology.
-
Knauf C, Cani PD, Perrin C, et al. Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage. J Clin Invest 2005; 115:3554-3563. In this comprehensive study investigating the role of GLP-1 in the CNS, it has been shown for the first time that central GLP-1 controls peripheral glucose utilization. These findings illustrate the novel mechanisms by which GLP-1 contributes to glucose homeostasis and underline how peripheral and CNS physiology are integrated in GLP-1 physiology.
-
-
-
-
30
-
-
0027495779
-
GLP-1 stimulates secretion of macromolecules from airways and relaxes pulmonary artery
-
Richter G, Feddersen O, Wagner U, et al. GLP-1 stimulates secretion of macromolecules from airways and relaxes pulmonary artery. Am J Physiol Lung Cell Mol Physiol 1993; 265 (4 Pt 1):L374-L381.
-
(1993)
Am J Physiol Lung Cell Mol Physiol
, vol.265
, Issue.4 PART 1
-
-
Richter, G.1
Feddersen, O.2
Wagner, U.3
-
31
-
-
0030013475
-
Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor
-
Bullock BP, Heller RS, Habener JF. Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor. Endocrinology 1996; 137:2968-2978.
-
(1996)
Endocrinology
, vol.137
, pp. 2968-2978
-
-
Bullock, B.P.1
Heller, R.S.2
Habener, J.F.3
-
32
-
-
0028042205
-
Changes in arterial blood pressure and heart rate induced by glucagon-like peptide-1-(7-36) amide in rats
-
Barragan JM, Rodriguez RE, Blazquez E. Changes in arterial blood pressure and heart rate induced by glucagon-like peptide-1-(7-36) amide in rats. Am J Physiol Endocrinol Physiol 1994; 266 (3 Pt 1):E459-E466.
-
(1994)
Am J Physiol Endocrinol Physiol
, vol.266
, Issue.3 PART 1
-
-
Barragan, J.M.1
Rodriguez, R.E.2
Blazquez, E.3
-
33
-
-
0032714917
-
Neural contribution to the effect of glucagon-like peptide-1-(7-36) amide on arterial blood pressure in rats
-
Barragan JM, Eng J, Rodriguez R, Blazquez E. Neural contribution to the effect of glucagon-like peptide-1-(7-36) amide on arterial blood pressure in rats. Am J Physiol Endocrinol Physiol 1999; 277 (5 Pt 1):E784-E791.
-
(1999)
Am J Physiol Endocrinol Physiol
, vol.277
, Issue.5 PART 1
-
-
Barragan, J.M.1
Eng, J.2
Rodriguez, R.3
Blazquez, E.4
-
34
-
-
0036307872
-
Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons
-
Yamamoto H, Lee CE, Marcus JN, et al. Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons. J Clin Invest 2002; 110:43-52.
-
(2002)
J Clin Invest
, vol.110
, pp. 43-52
-
-
Yamamoto, H.1
Lee, C.E.2
Marcus, J.N.3
-
35
-
-
0038577144
-
Cardiac function in mice lacking the glucagon-like peptide-1 receptor
-
Gros R, You X, Baggio LL, et al. Cardiac function in mice lacking the glucagon-like peptide-1 receptor. Endocrinology 2003; 144:2242-2252.
-
(2003)
Endocrinology
, vol.144
, pp. 2242-2252
-
-
Gros, R.1
You, X.2
Baggio, L.L.3
-
36
-
-
1442311383
-
Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion
-
Nikolaidis LA, Mankad S, Sokos GG, et al. Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion. Circulation 2004; 109:962-965.
-
(2004)
Circulation
, vol.109
, pp. 962-965
-
-
Nikolaidis, L.A.1
Mankad, S.2
Sokos, G.G.3
-
37
-
-
8544258807
-
Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease
-
Nystrom T, Gutniak MK, Zhang Q, et al. Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease. Am J Physiol Endocrinol Metab 2004; 287:E1209-E1215.
-
(2004)
Am J Physiol Endocrinol Metab
, vol.287
-
-
Nystrom, T.1
Gutniak, M.K.2
Zhang, Q.3
-
38
-
-
4344605042
-
Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy
-
Nikolaidis LA, Elahi D, Hentosz T, et al. Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy. Circulation 2004; 110:955-961.
-
(2004)
Circulation
, vol.110
, pp. 955-961
-
-
Nikolaidis, L.A.1
Elahi, D.2
Hentosz, T.3
-
39
-
-
28144441354
-
-
Nikolaidis LA, Elahi D, Shen YT, Shannon RP. Active metabolite of GLP-1 mediates myocardial glucose uptake and improves left ventricular performance in conscious dogs with dilated cardiomyopathy. Am J Physiol Heart Circ Physiol 2005; 289:H2401-H2408. The novelty in this paper is the apparent activity of GLP-1(9-36) on glucose metabolism and cardiac function in dogs
-
Nikolaidis LA, Elahi D, Shen YT, Shannon RP. Active metabolite of GLP-1 mediates myocardial glucose uptake and improves left ventricular performance in conscious dogs with dilated cardiomyopathy. Am J Physiol Heart Circ Physiol 2005; 289:H2401-H2408. The novelty in this paper is the apparent activity of GLP-1(9-36) on glucose metabolism and cardiac function in dogs.
-
-
-
-
40
-
-
11844269899
-
-
Nikolaidis LA, Doverspike A, Hentosz T, et al. Glucagon-like peptide-1 limits myocardial stunning following brief coronary occlusion and reperfusion in conscious canines. J Pharmacol Exp Ther 2005; 312:303-308. This study adds to the literature demonstrating the positive effects of GLP-1 on myocardial function by demonstrating a protective effect on ischemia in a clinically relevant animal model.
-
Nikolaidis LA, Doverspike A, Hentosz T, et al. Glucagon-like peptide-1 limits myocardial stunning following brief coronary occlusion and reperfusion in conscious canines. J Pharmacol Exp Ther 2005; 312:303-308. This study adds to the literature demonstrating the positive effects of GLP-1 on myocardial function by demonstrating a protective effect on ischemia in a clinically relevant animal model.
-
-
-
-
41
-
-
12144260853
-
-
Bose AK, Mocanu MM, Carr RD, et al. Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury. Diabetes 2005; 54:146-151. This careful study uses in-vivo and ex-vivo models to demonstrate that at least some GLP-1 effects on the heart are directly mediated through myocardial GLP-1r. This paper also identifies the outline of important intracellular signaling by the GLP-1r.
-
Bose AK, Mocanu MM, Carr RD, et al. Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury. Diabetes 2005; 54:146-151. This careful study uses in-vivo and ex-vivo models to demonstrate that at least some GLP-1 effects on the heart are directly mediated through myocardial GLP-1r. This paper also identifies the outline of important intracellular signaling by the GLP-1r.
-
-
-
-
42
-
-
0033513455
-
Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats
-
Xu G, Stoffers DA, Habener JF, Bonner-Weir S. Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes 1999; 48:2270-2276.
-
(1999)
Diabetes
, vol.48
, pp. 2270-2276
-
-
Xu, G.1
Stoffers, D.A.2
Habener, J.F.3
Bonner-Weir, S.4
-
43
-
-
0035046251
-
Glucagon-like peptide-1 causes pancreatic duodenal homeobox-1 protein translocation from the cytoplasm to the nucleus of pancreatic beta-cells by a cyclic adenosine monophosphate/protein kinase A-dependent mechanism
-
Wang X, Zhou J, Doyle ME, Egan JM. Glucagon-like peptide-1 causes pancreatic duodenal homeobox-1 protein translocation from the cytoplasm to the nucleus of pancreatic beta-cells by a cyclic adenosine monophosphate/protein kinase A-dependent mechanism. Endocrinology 2001; 142:1820-1827.
-
(2001)
Endocrinology
, vol.142
, pp. 1820-1827
-
-
Wang, X.1
Zhou, J.2
Doyle, M.E.3
Egan, J.M.4
-
44
-
-
0036896712
-
Glucagon-like peptide-1 receptor activation antagonizes voltage-dependent repolarizing K(+) currents in beta-cells: A possible glucose-dependent insulinotropic mechanism
-
MacDonald PE, Salapatek AM, Wheeler MB. Glucagon-like peptide-1 receptor activation antagonizes voltage-dependent repolarizing K(+) currents in beta-cells: a possible glucose-dependent insulinotropic mechanism. Diabetes 2002; 51 (Suppl 3):S443-S447.
-
(2002)
Diabetes
, vol.51
, Issue.SUPPL. 3
-
-
MacDonald, P.E.1
Salapatek, A.M.2
Wheeler, M.B.3
-
45
-
-
1842855402
-
Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells
-
Wang Q, Li L, Xu E, et al. Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells. Diabetologia 2004; 47:478-487.
-
(2004)
Diabetologia
, vol.47
, pp. 478-487
-
-
Wang, Q.1
Li, L.2
Xu, E.3
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46
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Li L, El-Kholy W, Rhodes CJ, Brubaker PL. Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B. Diabetologia 2005; 48:1339-1349. This report builds on previous work by this group, demonstrating the importance of PKB to mediate GLP-1 effects in β cells, and extends the findings to cytokine toxicity, a model relevant to type 1 diabetes.
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Li L, El-Kholy W, Rhodes CJ, Brubaker PL. Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B. Diabetologia 2005; 48:1339-1349. This report builds on previous work by this group, demonstrating the importance of PKB to mediate GLP-1 effects in β cells, and extends the findings to cytokine toxicity, a model relevant to type 1 diabetes.
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47
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-/- mice convincingly demonstrate that IRS2 is necessary for the growth effects of GLP-1 but not the effects to acutely stimulate insulin secretion.
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-/- mice convincingly demonstrate that IRS2 is necessary for the growth effects of GLP-1 but not the effects to acutely stimulate insulin secretion.
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48
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33745315716
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Buteau J, Spatz ML, Accili D. Transcription factor Fox01 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass. Diabetes 2006; 55:1190-1196. In this paper convincing evidence is provided that Fox01 is a major downstream mediator of GLP-1-activated PKB. This is a novel mechanism in GLP-1 signaling but is consistent with other information on Fox01 and the role of PKB
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Buteau J, Spatz ML, Accili D. Transcription factor Fox01 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass. Diabetes 2006; 55:1190-1196. In this paper convincing evidence is provided that Fox01 is a major downstream mediator of GLP-1-activated PKB. This is a novel mechanism in GLP-1 signaling but is consistent with other information on Fox01 and the role of PKB.
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49
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Wideman RD, Yu IL, Webber TD, et al. Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1). Proc Natl Acad Sci U S A 2006; 103:13468-13473. The importance of this paper is as a proof of concept for a gene therapy approach that could conceivably be applied to human islet transplantation.
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Wideman RD, Yu IL, Webber TD, et al. Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1). Proc Natl Acad Sci U S A 2006; 103:13468-13473. The importance of this paper is as a proof of concept for a gene therapy approach that could conceivably be applied to human islet transplantation.
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50
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Exenatide (exendin-4) improves insulin sensitivity and {beta}-cell mass in insulin-resistant obese fa/fa Zucker rats independent of glycemia and body weight
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This paper raises the important point that islet mass, like insulin secretion, must be viewed in the context of prevailing insulin sensitivity
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Gedulin BR, Nikoulina SE, Smith PA, et al. Exenatide (exendin-4) improves insulin sensitivity and {beta}-cell mass in insulin-resistant obese fa/fa Zucker rats independent of glycemia and body weight. Endocrinology 2005; 146:2069-2076. This paper raises the important point that islet mass, like insulin secretion, must be viewed in the context of prevailing insulin sensitivity.
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(2005)
Endocrinology
, vol.146
, pp. 2069-2076
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Gedulin, B.R.1
Nikoulina, S.E.2
Smith, P.A.3
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