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This result is not as obvious as usually assumed, because the CF 3 group in the trifluoromethylalkanes decreases their lipophilicity due to the strong Cδ+-CF3δ- dipoles.57 On the other side, the CF3CH2OH is considerably more lipophilic than CH3CH2OH cf. Table 6 in ref 57
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∥ is based on the atomic point charges of energetically optimized molecular geometries but also accounts for hybridization effects which sometimes yield up to 50% of the dipole moment. Details of this procedure are given in ref 25.
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