Pharmacokinetics of triptolide in Beagle dogs

Yaoxue Xuebao

Volumn 42, Issue 1, 2007, Pages 61-65

  Shao, Feng ^a   Wang, Guang Ji ^a   Sun, Jian Guo ^a   Xie, Hai Tang ^a   Zhang, Rong ^a   Zhu, Xiao Yan ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Absolute bioavailability; LC MS; Pharmacokinetics; Triptolide

Indexed keywords

DITERPENE; EPOXIDE; PHENANTHRENE DERIVATIVE; TRIPTOLIDE;

ANIMAL; AREA UNDER THE CURVE; ARTICLE; BIOAVAILABILITY; BLOOD; CHEMISTRY; DOG; DOSE RESPONSE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; MALE; MASS SPECTROMETRY; MEDICINAL PLANT; ORAL DRUG ADMINISTRATION; RANDOMIZATION; TRIPTERYGIUM;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DITERPENES; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPOXY COMPOUNDS; FEMALE; INJECTIONS, INTRAVENOUS; MALE; MASS SPECTROMETRY; PHENANTHRENES; PLANTS, MEDICINAL; RANDOM ALLOCATION; TRIPTERYGIUM;

EID: 33847748579     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Li XW, Weir MR. Radix Tripterygium wilfordii - a Chinese herbal medicine with potent immunosuppressive properties [J]. Transplantation, 1990,50:82-86.
2. Ho LJ, Chang DM, Chang ML. Mechanism of immunosuppression of the antirheumatic herb TWHf in human T cells [J]. J Rheumatol, 1999,26:14-24.
3. Tao X, Lipsky PE. The Chinese anti-inflammatory and immunosuppressive herbal remedy Tripterygium wilfordii Hook F [J]. Rheum Dis Clin North Am, 2000,26;29-50.
4. Liu J, Wu QL, Feng YH. Triptolide suppresses CD80 and CD86 expressions and IL-12 production in THP-1 cells [J]. Acta Pharmacol Sin, 2005,26:223-227.
5. Yang S, Chen J, Guo Z. Triptolide inhibits the growth and metastasis of solid tumors [J]. Mol Cancer Ther, 2003,2:65-72.
6. Gao XP, Li BG, Zhou J, et al. Antitumor activities and induction of apoptosis by triptolide [J]. Nat Prod Res Dev, 2000,12:18-21.
7. Yang LL, Zhang X, Yuan YS. Determination of tiptolide in human plasma by gas chromatography electron capture detection [J]. Chin J Chromatogr, 2001,19:58-59.
8. Wang Z, Wen J, Xing J, et al. Determination of triptolide and triptonide in human plasma by high-performance liquid chromatography [J]. Biomed Chromatogr, 2005, 19:60-62.
9. Liu L, Wang ZY, Huang GZ, et al. The influence of triptolide sub-chronic intoxication on kidney and testicle in mice [J]. Acta Univ Med Tongji, 2001,30:214-217.
10. Ding H, Wu JY, Tong J. The study of triptolide acute toxicity and its mechanism [J]. Chin Tradit Herb Drugs, 2004,27:115-118.