GTF2IRD1 regulates transcription by binding an evolutionarily conserved DNA motif 'GUCE'

FEBS Letters

Volumn 581, Issue 6, 2007, Pages 1233-1242

  Thompson, P D ^a   Webb, M ^a   Beckett, W ^a   Hinsley, T ^a   Jowitt, T ^a   Sharrocks, A D ^a   Tassabehji, M ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

DNA binding; GTF2IRD1; GUCE; isoforms; TFII I; Transcription regulation; Williams Beuren syndrome

Indexed keywords

HELIX LOOP HELIX PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GTF2IRD1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE; GENE CONTROL; GENETIC CONSERVATION; GOOSECOID GENE; HOXC8 GENE; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REGULATORY DNA SEQUENCE; SEQUENCE ANALYSIS; TRANSCRIPTION REGULATION; TROPONIN I SLOW GENE; WILLIAMS BEUREN SYNDROME;

CONSERVED SEQUENCE; DNA; GENE EXPRESSION REGULATION; GOOSECOID PROTEIN; HOMEODOMAIN PROTEINS; HUMANS; MUSCLE PROTEINS; NUCLEAR PROTEINS; PROTEIN BINDING; REGULATORY ELEMENTS, TRANSCRIPTIONAL; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TROPONIN I; WILLIAMS SYNDROME;

EID: 33847744283     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2007.02.040     Document Type: Article

References (33)

1. Ewart A.K., Morris C.A., Ensing G.J., Loker J., Moore C., Leppert M., and Keating M. A human vascular disorder, supravalvular aortic stenosis, maps to chromosome 7. Proc. Natl. Acad. Sci. USA 90 (1993) 3226-3230
2. Tassabehji M., Hammond P., Karmiloff-Smith A., Thompson P., Thorgeirsson S.S., Durkin M.E., Popescu N.C., Hutton T., Metcalfe K., Rucka A., Stewart H., Read A.P., Maconochie M., and Donnai D. GTF2IRD1 in craniofacial development of humans and mice. Science 310 (2005) 1184-1187
3. Gagliardi C., Bonaglia M.C., Selicorni A., Borgatti R., and Giorda R. Unusual cognitive and behavioural profile in a Williams syndrome patient with atypical 7ql 1.23 deletion. J. Med. Genet. 40 (2003) 526-530
4. Korenberg J.R., Chen X.-N., Hirota H., Lai Z., Bellugi U., Burian D., Roe B., and Matsuoka R. Genome structure and cognitive map of Williams syndrome. J. Cognit. Neurosci. 12 (2000) 89S-107S
5. Hirota H., Matsuoka R., Chen X.N., Salandanan L.S., Lincoln A., Rose F.E., Sunahara M., Osawa M., Bellugi U., and Korenberg J.R. Williams syndrome deficits in visual spatial processing linked to GTF2IRD1 and GTF21 on chromosome 7qll.23. Genet. Med. 5 (2003) 311-321
6. Botta A., Novelli G., Mari A., Novelli A., Sabani M., Korenberg J., Osborne L.R., Digilio M.C., Giannotti A., and Dallapiccola B. Detection of an atypical 7ql 1.23 deletion in Williams syndrome patients which does not include the STX1A and FZD3 genes. J. Med. Genet. 36 (1999) 478-480
7. Karmiloff-Smith A., Grant J., Ewing S., Carette M.J., Metcalfe K., Donnai D., Read A.P., and Tassabehji M. Using case study comparisons to explore genotype-phenotype correlations in Williams-Beuren syndrome. J. Med. Genet. 40 (2003) 136-140
8. Danoff S.K., Taylor H.E., Blackshaw S., and Desiderio S. TFII-I, a candidate gene for Williams syndrome cognitive profile: parallels between regional expression in mouse brain and human phenotype. Neuroscience 123 (2004) 931-938
9. Tipney H.J., Hinsley T.A., Brass A., Metcalfe K., Donnai D., and Tassabehji M. Isolation and characterisation of GTF2IRD2, a novel fusion gene and member of the TFII-I family of transcription factors, deleted in Williams-Beuren syndrome. Eur. J. Hum. Genet. 12 (2004) 551-560
10. Hinsley T.A., Cunliffe P., Tipney H.J., Brass A., and Tassabehji M. Comparison of TFII-I gene family members deleted in Williams-Beuren syndrome. Protein Sci. 13 (2004) 2588-2599
11. Polly P., Haddadi L.M., Issa L.L., Subramaniam N., Palmer S.J., Tay E.S., and Hardeman E.C. hMusTRDlalphal represses MEF2 activation of the troponin I slow enhancer. J. Biol. Chem. 278 (2003) 36603-36610
12. Ring C., Ogata S., Meek L., Song J., Ohta T., Miyazono K., and Cho K.W. The role of a Williams-Beuren syndrome-associated helix-loop-helix domain-containing transcription factor in activin/nodal signaling. Genes Dev. 16 (2002) 820-835
13. Vullhorst D., and Buonanno A. Multiple GTF2I-like repeats of general transcription factor 3 exhibit DNA binding properties. Evidence for a common origin as a sequence-specific DNA interaction module. J. Biol. Chem. 280 (2005) 31722-31731
14. Vullhorst D., and Buonanno A. Characterization of general transcription factor 3, a transcription factor involved in slow muscle-specific gene expression. J. Biol. Chem. 278 (2003) 8370-8379
15. Cheriyath V., and Roy A.L. Structure-function analysis of TFII-I. Roles of the N-terminal end, basic region, and I-repeats. J. Biol. Chem. 276 (2001) 8377-8383
16. Bayarsaihan D., and Ruddle F.H. Isolation and characterization of BEN, a member of the TFII-I family of DNA-binding proteins containing distinct helix-loop-helix domains. Proc. Natl. Acad. Sci. USA 97 (2000) 7342-7347
17. Tantin D., Tussie-Luna M.I., Roy A.L., and Sharp P.A. Regulation of immunoglobulin promoter activity by TFII-I class transcription factors. J. Biol. Chem. 279 (2004) 5460-5469
18. O'Mahoney J.V., Guven K.L., Lin J., Joya J.E., Robinson C.S., Wade R.P., and Hardeman E.C. Identification of a novel slow-muscle-fiber enhancer binding protein, MusTRDl. Mol. Cell Biol. 18 (1998) 6641-6652
19. Tussie-Luna M.I., Bayarsaihan D., Ruddle F.H., and Roy A.L. Repression of TFII-I-dependent transcription by nuclear exclusion. Proc. Natl. Acad. Sci. USA 98 (2001) 7789-7794
20. Jackson T.A., Taylor H.E., Sharma D., Desiderio S., and Danoff S.K. Vascular endothelial growth factor receptor-2: counter-regulation by the transcription factors, TFII-I and TFII-IRD1. J. Biol. Chem. 280 (2005) 29856-29863
21. Ku M., Sokol S.Y., Wu J., Tussie-Luna M.I., Roy A.L., and Hata A. Positive and negative regulation of the transforming growth factor beta/activin target gene goosecoid by the TFII-I family of transcription factors. Mol. Cell Biol. 25 (2005) 7144-7157
22. Tussie-Luna M.I., Bayarsaihan D., Seto E., Ruddle F.H., and Roy A.L. Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxbeta. Proc. Natl. Acad. Sci. USA 99 (2002) 12807-12812
23. Garside H., Stevens A., Farrow S., Normand C., Houle B., Berry A., Maschera B., and Ray D. Glucocorticoid ligands specify different interactions with NF-{kappa}B by allosteric effects on the glucocorticoid receptor DNA binding domain. J. Biol. Chem. 279 (2004) 50050-50059
24. Roberts E.C., Deed R.W., Inoue T., Norton J.D., and Sharrocks A.D. Id helix-loop-helix proteins antagonize Pax transcription factor activity by inhibiting DNA binding. Mol. Cell. Biol. 21 (2001) 524-533
25. Powell L.M., Dryden D.T.F., Willcock D.F., Pain R.H., and Murray N.E. DNA recognition by the EcoK methyltransferase : the influence of DNA methylation and the cofactor S-adenosyl-methionine. J. Mol. Biol. 234 (1993) 60-71
26. Yang S.-H., Yates P.R., Whitmarsh A.J., Davis R.J., and Sharrocks A.D. The Elk-1 ETS-domain transcription factor contains a mitogen-activated protein kinase targeting motif. Mol. Cell. Biol. 18 (1998) 710-720
27. Calvo S., Vullhorst D., Venepally P., Cheng J., Karavanova I., and Buonanno A. Molecular dissection of DNA sequences and factors involved in slow muscle-specific transcription. Mol. Cell Biol. 21 (2001) 8490-8503
28. Johnson W.C. Analyzing protein circular dichroism spectra for accurate secondary structures. Prot.: Struct. Funct. Genet. 35 (1999) 307-312
29. Osbome L.R., Campbell T., Daradich A., Scherer S.W., and Tsui L.-C. Identification of a putative transcription factor gene (WBSCR11) that is commonly deleted in Williams-Beuren syndrome. Genomics 57 (1999) 279-284
30. Tassabehji M., Carette M., Wilmot C., Donnai D., Read A.P., and Metcalfe K. A transcription factor involved in skeletal muscle gene expression is deleted in patients with Williams syndrome. Eur. J. Hum. Genet. 7 (1999) 737-747
31. Lenhard B., Sandelin A., Mendoza L., Engstrom P., Jareborg N., and Wasserman W. Identification of conserved regulatory elements by comparative genome analysis. J. Biol. 2 (2003) 13
32. Juan A.H., and Ruddle F.H. Enhancer timing of Hox gene expression: deletion of the endogenous Hoxc8 early enhancer. Development 130 (2003) 4823-4834
33. Crooks G.E., Hon G., Chandonia J.-M., and Brenner S.E. WebLogo: a sequence logo generator. Genome Res. 14 (2004) 1188-1190