Intravenous iloprost: A new therapeutic option for patients with post-transplant distal limb syndrome (PTDLS)

American Journal of Transplantation

Volumn 7, Issue 3, 2007, Pages 667-671

  Tillmann, F P ^a   Jager M ^a   Blondin, D ^a   Schooldermann, D ^a   Voiculescu, A ^a   Sucker, C ^a   Grabensee, B ^a   Krauspe, R ^a   Hetzel, G R ^a  

^a UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

Author keywords

Bone marrow edema; Iloprost; Kidney transplantation; Osteonecrosis; PTDLS

Indexed keywords

ALKALINE PHOSPHATASE; CREATININE; CYCLOSPORIN A; DACLIZUMAB; ILOPROST; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PARATHYROID HORMONE; PREDNISOLONE; TACROLIMUS;

ACUTE GRAFT REJECTION; ADULT; AGED; ALKALINE PHOSPHATASE BLOOD LEVEL; APPLICATION SITE IRRITATION; ARTICLE; BONE DISEASE; BONE NECROSIS; BONE PAIN; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORTICOSTEROID INDUCED OSTEOPOROSIS; CREATININE BLOOD LEVEL; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG SUBSTITUTION; FEMALE; HUMAN; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; KNEE PAIN; LABORATORY TEST; MALE; NEPHROTOXICITY; NUCLEAR MAGNETIC RESONANCE IMAGING; PAIN ASSESSMENT; POSTTRANSPLANT DISTAL LIMB SYNDROME; PRIORITY JOURNAL; SIDE EFFECT; THERAPY EFFECT; TREATMENT OUTCOME; TREATMENT RESPONSE; VISUAL ANALOG SCALE;

ADULT; AGED; BONE DISEASES; FEMALE; FOOT BONES; HUMANS; ILOPROST; INFUSIONS, INTRAVENOUS; KIDNEY TRANSPLANTATION; KNEE; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PAIN, POSTOPERATIVE; POSTOPERATIVE COMPLICATIONS; SYNDROME; TREATMENT OUTCOME; VASODILATOR AGENTS;

EID: 33847738631     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2007.01662.x     Document Type: Article

References (28)

1. Parfrey PS, Fargo D, Parfrey NA, Hanley JA, Guttman RD. The decreased incidence of aseptic necrosis in renal transplant recipients: A case control study. Transplantation 1986; 41: 182-187.
2. Heaf JG. Bone disease after renal transplantation. Transplantation 2003; 75: 315-325.
3. Coates PTH, Tie M, Russ GR, Mathew TH. Transient bone marrow edema in renal transplantation: A distinct post-transplantation syndrome with a characteristic MRI appearance. Am J Transplant 2002; 2: 467-470.
4. Lucas VP, Ponge TD, Plougastel-Lucas ML, Glemain P, Hourmant M, Soulillou JP. Musculoskeletal pain in renal-transplant recipients. N Engl J Med 1991; 325: 1449-1450.
5. Goffin E, Vande Berg B, Devogelaer JP et al. Post-renal transplant syndrome of transient lower limb joint pain: Description under a tacrolimus-based immunosuppression. Clin Nephro 2003; 59: 98-105.
6. Hetzel GR, Malms J, May P et al. Post-transplant distal-limb bone marrow oedema: MR imaging and therapeutic considerations. Nephrol Dial Tranplant 2000; 15: 1859-1864.
7. Gauthier VJ, Barbosa LM. Bone pain in transplant recipients responsive to calcium channel blockers. Ann Intern Med 1994; 121: 863-865.
8. Puig I, Mari JM, Martinez-Miralles E et al. Reflex sympathetic dystrophy syndrome of the lower limbs in a renal transplant patient treated with Tacrolimus. Transplantation 2000; 70: 210-211.
9. Eustace S, Keogh C, Blake M, Ward RJ, Oder PD, Dimasi M. MR imaging of bone oedema: Mechanism and interpretation. Clin Radiol 2001; 56: 4-12.
10. Stein B, Takizawa M, Katz I et al. Salmon calcitonin prevents cyclosporine-A-induced high turnover bone loss. Endocrinology 1991; 129: 92-98.
11. Aigner N, Petje G, Steinbock G, Schneider W, Krasny C, Landsiedl F. Treatment of bone marrow edema of the talus with the prostacyclin analogue iloprost: An MRI-controlled investigation of a new method. J Bone Joint Surg (Br) 2001; 83-B: 855-858.
12. Aigner N, Petje G, Schneider W, Krasny C, Grill F, Landsiedl F. Juvenile bone-marrow oedema of the acetabulum treated by iloprost. J Bone Joint Surg (Br) 2002; 84-B: 1050-1052.
13. Meizer R, Radda C, Stolz G et al. MRI-controlled analysis of 104 patients with painful bone marrow edema in different joint localizations treated with the prostacyclin analogue iloprost. Wien Klin Wochenschr 2005; 117: 278-286.
14. Disch AC, Matziolis G, Perka C. The management of necrosis-associated and idiopathic bone-marrow oedema of the proximal femur by intravenous iloprost. J Bone Joint Surg (Br) 2005; 87-B: 560-564.
15. Olschewski H, Simonneau G, Galie N et al. Inhaled iloprost for severe pulmonary hypertension. N Engl J Med 2002; 347: 322-329.
16. Grant SM, Goa KL. Iloprost: A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in peripheral vascular disease, myocardial ischemia and extracorporeal circulation procedures. Drugs 1992; 43: 889-924.
17. Rambausek M, Ritz E, Pomer S, Möhring K, Röhl L. Alkaline phosphatase levels in renal transplant recipients receiving cyclosporin or azathioprine/steroids. Lancet 1988; 1: 247.
18. Kahan BD. Cyclosporine. N Engl J Med 1989; 321: 1725-1738.
19. Cvetkovic M, Mann GN, Romero DF et al. The deleterious effects of long-term cyclosporine A, cyclosporine G and FK506 on bone mineral metabolism in vivo. Transplantation 1994; 57: 1231-1237.
20. Movsowitz C, Epstein S, Fallon M, Ismail F, Thomas S. Cyclosporin-A in vivo produces severe osteopenia in the rat: Effect of dose and duration of administration. Endocrinology 1988; 123: 2571-2577.
21. Briner VA, Landmann J, Brunner FP, Thiel G. Cyclosporin A induced transient rise in plasma alkaline phosphatase in kidney transplant patients. Transpl Int 1993; 6: 99-107.
22. Isaacs KL. Severe bone pain as an adverse effect of cyclosporin therapy for Crohn's disease. Inflamm Bowel Dis 1998, 4: 95-97.
23. Le Guen E, Morel D, L'Azou B, Cambar J, Potaux L. Effect of cyclosporin and the prostacyclin analogue iloprost on human glomerular vasoreactivity. Nephrol Dial Transplant 1994; 9: 413-415.
24. Hansen MJ, Christensen NJ, Fogh-Andersen N, Strandgaard S. Effects of the prostacyclin analogue iloprost on cyclosporin-induced renal hypoperfusion in stable renal transplant recipients. Nephrol Dial Transplant 1996; 11: 340-346.
25. Wadhwa S, Choudhary S, Voznesensky M, Epstein M, Raisz L, Pilbeam C. Fluid flow induced COX-2 expression in MC3T3-E1 osteoblasts via a PKA signalling pathway. Biochem Biophys Res Commu 2002; 297: 46-51.
26. Glanstchnig H, Varga F, Rumpler M, Klaushofer K. Prostacyclin (PGI2): A potential mediator of c-fos expression induced by hydrostatic pressure in osteoblastic cells. Eur J Clin Invest 1996; 26: 544-548.
27. Xu M, Choudhary S, Goltzman D et al. Do cyclooxygenase-2 knockout mice have primary hyperparathyroidism? Endocrinology 2005; 146: 1843-1853.
28. Okada Y, Pilbeam C, Raisz L, Tanaka Y. Role of cyclooxygenase-2 in bone resorption. J. UOEH 2003; 25: 185-195.