Effect of the immunomodulator leflunomide on the induction of endometriosis in an experimental rat model

Fertility and Sterility

Volumn 87, Issue 3, 2007, Pages 698-701

  Aytan, Hakan ^a   Caglar, Pinar ^b   Uygur, Dilek ^b   Zergeroglu, Sema ^b   Batioglu, Sertac ^b  

^a GAZIOSMANPASA UNIVERSITY   (Turkey)

^b Zekai Tahir Burak Women's Health Training and Research Hospital   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOMODULATING AGENT; LEFLUNOMIDE; TERIFLUNOMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENDOMETRIOSIS; EXPERIMENTAL RAT; EXPLANT; FEMALE; HISTOPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; VAGINA SMEAR;

ANIMALS; DISEASE MODELS, ANIMAL; ENDOMETRIOSIS; FEMALE; IMMUNOLOGIC FACTORS; ISOXAZOLES; RATS; UTERUS;

EID: 33847723059     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2006.07.1527     Document Type: Article

References (24)

1. Garcia-Velasco J.A., Arici A., Zreik T., Naftolin F., and Mor G. Macrophage derived growth factors modulate Fas ligand expression in cultured endometrial stromal cells: a role in endometriosis. Mol Hum Reprod 5 (1999) 642-650
2. Lebovic D.I., Bentzien F., Chao V.A., Garrett E.N., Meng Y.G., and Taylor R.N. Induction of an angiogenic phenotype in endometriotic stromal cell cultures by interleukin-1 β. Mol Hum Reprod 6 (2000) 269-275
3. Wu M.Y., and Ho H.N. The role of cytokines in endometriosis. Am J Reprod Immunol 49 (2003) 285-296
4. D'Hooghe T.M., Nugent N.P., Cuneo S., Chai D.C., Deer F., Debrock S., et al. Recombinant human TNFRSF1A (r-hTBP1) inhibits the development of endometriosis in baboons: a prospective, randomized, placebo- and drug-controlled study. Biol Reprod 74 (2006) 131-136
5. Keenan J.A., Chen T.T., Chadwell N.L., Torry D.S., and Caudle M.R. IL-1 beta, TNF-alpha, and IL-2 in peritoneal fluid and macrophage-conditioned media of women with endometriosis. Am J Reprod Immunol 34 (1995) 381-385
6. Cao X., Yang D., Song M., Murphy A., and Parthasarathy S. The presence of endometrial cells in the peritoneal cavity enhances monocyte recruitment and induces inflammatory cytokines in mice: implications for endometriosis. Fertil Steril 82 Suppl 3 (2004) 999-1007
7. Hornung D., Bentzien F., Wallwiener D., Kiesel L., and Taylor R.N. Chemokine bioactivity of RANTES in endometriotic and normal endometrial stromal cells and peritoneal fluid. Mol Hum Reprod 7 (2001) 163-168
8. Falconer H., Mwenda J.M., Chai D.C., Wagner C., Cornillie F.J., and D'Hooghe T.M. Treatment with antiTNF antibody c5N reduces the extent of induced endometriosis in the baboon. Fertil Steril 82 Suppl 2 (2004) 54-55
9. D'Antonio M., Martelli F., Peano S., Papoian R., and Borrelli F. Ability of recombinant human TNF binding protein-1 (r-hTBP-1) to inhibit the development of experimentally-induced endometriosis in rats. J Reprod Immunol 48 (2000) 81-98
10. Rozman B. Clinical pharmacokinetics of leflunomide. Clin Pharmacokinet 41 (2002) 421-430
11. Breedveld F.C., and Dayer J.M. Leflunomide: mode of action in the treatment of rheumatoid arthritis. Ann Rheum Dis 59 (2000) 841-849
12. Vernon M.W., and Wilson E.A. Studies on the surgical induction of endometriosis in the rat. Fertil Steril 44 (1985) 684-694
13. Lebovic D.I., Kir M., and Casey C.L. Peroxisome proliferator-activated receptor-gamma induces regression of endometrial explants in a rat model of endometriosis. Fertil Steril 82 Suppl 3 (2004) 1008-1013
14. Keenan J.A., Williams-Boyce P.K., Massey P.J., Chen T.T., Caudle M.R., and Bukovsky A. Regression of endometrial explants in a rat model of endometriosis treated with the immune modulators loxoribine and levamisole. Fertil Steril 72 (1999) 135-141
15. Arici A., Oral E., Attar E., Tazuke S.I., and Olive D.L. Monocyte chemotactic protein-1 concentration in peritoneal fluid of women with endometriosis and its modulation of expression in mesothelial cells. Fertil Steril 67 (1997) 1065-1072
16. Murray B.E. New aspects of antimicrobial resistance and the resulting therapeutic dilemmas. J Infect Dis 163 (1991) 1184-1194
17. Sharpe K.L., Zimmer R.L., Khan R.S., and Penney L.L. Proliferative and morphogenic changes induced by the coculture of rat uterine and peritoneal cells: a cell culture model for endometriosis. Fertil Steril 58 (1992) 1220-1229
18. Sharpe K.L., Zimmer R.L., Griffin W.T., and Penney L.L. Polypeptides synthesized and released by human endometriosis differ from those of the uterine endometrium in cell and tissue explant culture. Fertil Steril 60 (1993) 839-851
19. Isaacson K.B., Xu Q., and Lyttle C.R. The effect of estradiol on the production and secretion of complement component 3 by the rat uterus and surgically induced endometriotic tissue. Fertil Steril 55 (1991) 395-402
20. Mladenovic V., Domljan Z., Rozman B., Jajic I., Mihajlovic D., Dordevic J., et al. Safety and effectiveness of leflunomide in the treatment of patients with active rheumatoid arthritis. Results of a randomized, placebo-controlled, phase II study. Arthritis Rheum 38 (1995) 1595-1603
21. Strand V., Cohen S., Schiff M., Weaver A., Fleischmann R., Cannon G., et al., Leflunomide Rheumatoid Arthritis Investigators Group. Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Arch Intern Med 159 (1999) 2542-2550
22. Liote H. Respiratory complications of new treatments for rheumatoid arthritis. Rev Mal Respir 21 (2004) 1107-1115
23. Martin K., Bentaberry F., Dumoulin C., Longy-Boursier M., Lifermann F., Haramburu F., et al. Neuropathy associated with leflunomide: a case series. Ann Rheum Dis 64 (2005) 649-650
24. Gensburger D., Kawashima M., Marotte H., Kanitakis J., and Miossec P. Lupus erythematosus with leflunomide: induction or reactivation?. Ann Rheum Dis 64 (2005) 153-155