Regression of endometrial explants in a rat model of endometriosis treated with the immune modulators loxoribine and levamisole

Fertility and Sterility

Volumn 72, Issue 1, 1999, Pages 135-141

  Keenan, Jeffrey A ^a   Massey, Pamela J ^b   Chen, Thomas T ^b   Caudle, Michael R ^a   Bukovsky, Antonin ^a  

^a UNIVERSITY OF TENNESSEE GRADUATE SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TENNESSEE   (United States)

Author keywords

Endometriosis; Immune modulators; Immunohistochemistry; Immunotherapy; Levamisole; Loxoribine

Indexed keywords

LEVAMISOLE; LOXORIBINE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DENDRITIC CELL; ENDOMETRIOSIS; ENDOMETRIUM; EXPLANT; FEMALE; IMMUNOHISTOCHEMISTRY; INTRAPERITONEAL DRUG ADMINISTRATION; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; RAT; STROMA CELL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL COUNT; DISEASE MODELS, ANIMAL; ENDOMETRIOSIS; ENDOMETRIUM; EPITHELIAL CELLS; FEMALE; GUANOSINE; IMMUNOHISTOCHEMISTRY; KILLER CELLS, NATURAL; LEVAMISOLE; MACROPHAGES; PROSPECTIVE STUDIES; RATS; RATS, SPRAGUE-DAWLEY; STROMAL CELLS;

EID: 0033168742     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0015-0282(99)00157-0     Document Type: Article

References (37)

1. Oral E., Arici A. Pathogenesis of endometriosis. Obstet Gynecol Clin North Am. 24:1997;219-233.
2. Wood D.H., Yochmowitz M.G., Salmon Y.L., Eason R.L., Boster R.A. Proton irradiation and endometriosis. Aviat Space Environ Med. 54:1983;718-724.
3. Rier S.E., Martin D.C., Bowman R.E., Dmowski W.P., Becker J.L. Endometriosis in rhesus monkeys (Macaca mulatta) following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fundam Appl Toxicol. 21:1993;433-441.
4. Fanton J.W., Golden J.G. Radiation-induced endometriosis in Macaca mulatta. Radiat Res. 126:1991;141-146.
5. Steele R.W., Dmowski W.P., Marmer D.J. Immunologic aspects of human endometriosis. Am J Reprod Immunol. 6:1984;33-36.
6. Cunningham D.S., Hansen K.A., Coddington C.C. Changes in T-cell regulation of responses to self antigens in women with pelvic endometriosis. Fertil Steril. 58:1992;114-119.
7. Dmowski W.P., Steele R.W., Baker G.F. Deficient cellular immunity in endometriosis. Am J Obstet Gynecol. 141:1981;377-383.
8. Vigano P., Vercellini P., Di Blasio A.M., Colombo A., Candiani G.B., Vignali M. Deficient antiendometrium lymphocyte-mediated cytotoxicity in patients with endometriosis. Fertil Steril. 56:1991;894-899.
9. Oosterlynck D.J., Cornillie F.J., Waer M., Vandeputte M., Koninckx P.R. Women with endometriosis show a defect in natural killer activity resulting in a decreased cytotoxicity to autologous endometrium. Fertil Steril. 56:1991;45-51.
10. Oosterlynck D.J., Meuleman C., Waer M., Vandeputte M., Koninckx P.R. The natural killer activity of peritoneal fluid lymphocytes is decreased in women with endometriosis. Fertil Steril. 58:1992;290-295.
11. Oosterlynck D.J., Meuleman C., Waer M., Koninckx P.R., Vandeputte M. Immunosuppressive activity of peritoneal fluid in women with endometriosis. Obstet Gynecol. 82:1993;206-212.
12. Dmowski W.P., Gebel H.M., Braun D.P. The role of cell-mediated immunity in pathogenesis of endometriosis. Acta Obstet Gynecol Scand Suppl. 159:1994;7-14.
13. Pope B.L., MacIntyre J.P., Kimball E., Lee S., Zhou L., Taylor G.R., et al. The immunostimulatory compound 7-allyl-8-oxoguanosine (loxoribine) induces a distinct subset of murine cytokines. Cell Immunol. 162:1995;333-339.
14. Goodman M.G., Reitz A.B., Chen R., Bobardt M.D., Goodman J.H., Pope B.L. Selective modulation of elements of the immune system by low molecular weight nucleosides. J Pharmacol Exp Ther. 274:1995;1552-1557.
15. Pope B.L., Sigindere J., Chourmouzis E., MacIntyre P., Goodman M.G. 7-Allyl-8-oxoguanosine (loxoribine) inhibits the metastasis of B16 melanoma cells and has adjuvant activity in mice immunized with a B16 tumor vaccine. Cancer Immunol Immunother. 38:1994;83-91.
16. Holland C.V., O'Shea E., Asaolu S.O., Turley O., Crompton D.W. A cost-effectiveness analysis of anthelminthic intervention for community control of soil-transmitted helminth infection levamisole and Ascaris lumbricoides . J Parasitol. 82:1996;527-530.
17. Lopez M. Adjuvant therapy of colorectal cancer. Dis Colon Rectum. 37:1994;S86-S91.
18. Vernon M.W., Wilson E.A. Studies on the surgical induction of endometriosis in the rat. Fertil Steril. 44:1985;684-694.
19. Bukovsky A., Chen T.T., Wimalasena J., Caudle M.R. Cellular localization of luteinizing hormone receptor immunoreactivity in the ovaries of immature, gonadotropin-primed and normal cycling rats. Biol Reprod. 48:1993;1367-1382.
20. Lea R.G., Clark D.A. Macrophages and migratory cells in endometrium relevant to implantation. Baillieres Clin Obstet Gynaecol. 5:1991;25-59.
21. Head J.R., Billingham R.E. Concerning the immunology of the uterus. Am J Reprod Immunol Microbiol. 10:1986;76-81.
22. Betjes M.G., Tuk C.W., Struijk D.G., Krediet R.T., Arisz L., Beelen R.H. Antigen-presenting capacity of macrophages and dendritic cells in the peritoneal cavity of patients treated with peritoneal dialysis. Clin Exp Immunol. 94:1993;377-384.
23. Pavli P., Hume D.A., Van De Pol E., Doe W.F. Dendritic cells, the major antigen-presenting cells of the human colonic lamina propria. Immunology. 78:1993;132-141.
24. Gaytan F., Bellido C., Morales C., Reymundo C., Aguilar E., van Rooijen N. Selective depletion of testicular macrophages and prevention of Leydig cell repopulation after treatment with ethylene dimethane sulfonate in rats. J Reprod Fertil. 101:1994;175-182.
25. Bukovsky A, Caudle MR, Keenan JA, Wimalasena J, McKenzie PP. Thy-1 differentiation protein and monocyte-derived cells during regeneration and aging of human placental villi. Am J Reprod Immunol. In press.
26. Bennett N.T., Schultz G.S. Growth factors and wound healing biochemical properties of growth factors and their receptors . Am J Surg. 165:1993;728-737.
27. Witz C.A., Montoya I.A., Dey T.D., Schenken R.S. Characterization of lymphocyte subpopulations and T cell activation in endometriosis. Am J Reprod Immunol. 32:1994;173-179.
28. Marshall R.J., Jones D.B. An immunohistochemical study of lymphoid tissue in human endometrium. Int J Gynecol Pathol. 7:1988;225-235.
29. King A., Wellings V., Gardner L., Loke Y.W. Immunocytochemical characterization of the unusual large granular lymphocytes in human endometrium throughout the menstrual cycle. Hum Immunol. 24:1989;195-205.
30. Bulmer J.N. Immune aspects of pathology of the placental bed contributing to pregnancy pathology. Baillieres Clin Obstet Gynaecol. 6:1992;461-488.
31. Kamat B.R., Isaacson P.G. The immunocytochemical distribution of leukocytic subpopulations in human endometrium. Am J Pathol. 127:1987;66-73.
32. Pope B.L., Chourmouzis E., Sigindere J., Capetola R.J., Lau C.Y. In vivo enhancement of murine natural killer cell activity by 7-allyl-8-oxoguanosine (loxoribine). Int J Immunopharmacol. 14:1992;1375-1382.
33. Pope B.L., Chourmouzis E., Victorino L., MacIntyre J.P., Capetola R.J., Lau C.Y. Loxoribine (7-allyl-8-oxoguanosine) activates natural killer cells and primes cytolytic precursor cells for activation by IL-2. J Immunol. 151:1993;3007-3017.
34. Pope B.L., Chourmouzis E., Lee S., Goodman M.G. Enhancement of immunostimulatory activity by dual substitution of C8-substituted guanine ribonucleosides correlation with increased cytokine secretion . J Immunother Emphasis Tumor Immunol. 17:1995;98-108.
35. Bukovsky A., Michael S.D., Presl J. Cell-mediated and neural control of morphostasis. Med Hypotheses. 36:1991;261-268.
36. Bukovsky A., Caudle M.R., Keenan J.A., Wimalasena J., Upadhyaya N.B., Van Meter S.E. Is irregular regression of corpora lutea in climacteric women caused by age-induced alterations in the "tissue control system"? Am J Reprod Immunol. 36:1996;327-341.
37. Ramey J.W., Booker S.S., Kanbour-Shakir A., Campbell A.E., Sharpe-Timms K.L., Archer D.F. Inability to establish ectopic endometrium in a natural killer cell-deficient murine model. Immunologic, histologic and histochemical assessment. J Reprod Med. 41:1996;807-814.