메뉴 건너뛰기




Volumn 53, Issue 2, 2007, Pages 127-131

The dihydrouracil/uracil ratios in plasma and toxicities of 5-fluorouracil-based adjuvant chemotherapy in colorectal cancer patients

Author keywords

5 Fluorouracil associated toxicity; Colorectal cancer; Dihydropyrimidine dehydrogenase; Dihydrouracil; Uracil

Indexed keywords

DIHYDROPYRIMIDINE DEHYDROGENASE; DIHYDROURACIL; FLUOROURACIL; FOLINIC ACID; URACIL;

EID: 33847721425     PISSN: 00093157     EISSN: None     Source Type: Journal    
DOI: 10.1159/000099984     Document Type: Article
Times cited : (33)

References (19)
  • 1
    • 8344245311 scopus 로고    scopus 로고
    • Recurrent thrombophlebitis in a colon cancer patient with C677T heterozygous genotype for MTHFR treated with 5-fluorouracil-based adjuvant chemotherapy
    • Schiavon G, Vincenzi B, Santini D, Avvisati G, Tonini G: Recurrent thrombophlebitis in a colon cancer patient with C677T heterozygous genotype for MTHFR treated with 5-fluorouracil-based adjuvant chemotherapy. Chemotherapy 2004;50:194-195.
    • (2004) Chemotherapy , vol.50 , pp. 194-195
    • Schiavon, G.1    Vincenzi, B.2    Santini, D.3    Avvisati, G.4    Tonini, G.5
  • 2
    • 3342899466 scopus 로고    scopus 로고
    • A new perspective on cardiotoxicity of 5-fl uorouracil. A novel research tool 'cardiac ultrasonic integrated backscatter analysis' indicates transient, subclinical myocardial dysfunction due to high-dose leucovorin and infusional 5-fluorouracil regimen
    • Barutca S, Ceyhan C, Meydan N, Ozturk B, Tekten T, Onbasili A, Kadikoylu G, Bolaman Z: A new perspective on cardiotoxicity of 5-fl uorouracil. A novel research tool 'cardiac ultrasonic integrated backscatter analysis' indicates transient, subclinical myocardial dysfunction due to high-dose leucovorin and infusional 5-fluorouracil regimen. Chemotherapy 2004;50:113-118.
    • (2004) Chemotherapy , vol.50 , pp. 113-118
    • Barutca, S.1    Ceyhan, C.2    Meydan, N.3    Ozturk, B.4    Tekten, T.5    Onbasili, A.6    Kadikoylu, G.7    Bolaman, Z.8
  • 3
    • 0042743821 scopus 로고    scopus 로고
    • Oxaliplatin with weekly bolus 5-fluorouracil and leucovorin in pretreated advanced colorectal cancer patients: A phase II study
    • Yang TS, Chen JS, Tang R, Chiang JM, Hsieh PS, Yeh CY, Changchien CR: Oxaliplatin with weekly bolus 5-fluorouracil and leucovorin in pretreated advanced colorectal cancer patients: a phase II study. Chemotherapy 2003;49:194-199.
    • (2003) Chemotherapy , vol.49 , pp. 194-199
    • Yang, T.S.1    Chen, J.S.2    Tang, R.3    Chiang, J.M.4    Hsieh, P.S.5    Yeh, C.Y.6    Changchien, C.R.7
  • 4
    • 0036303541 scopus 로고    scopus 로고
    • Profound dihydropyrimidine dehydrogenase deficiency resulting from a novel compound heterozygote genotype
    • Johnson MR, Wang K, Diasio RB: Profound dihydropyrimidine dehydrogenase deficiency resulting from a novel compound heterozygote genotype. Clin Cancer Res 2002;8:768-774.
    • (2002) Clin Cancer Res , vol.8 , pp. 768-774
    • Johnson, M.R.1    Wang, K.2    Diasio, R.B.3
  • 5
    • 0031876466 scopus 로고    scopus 로고
    • Putative role of dihydropyrimidine dehydrogenase in the toxic side effect of 5-fluorouracil in colorectal cancer patients
    • Katona C, Kralovanszky J, Rosta A, Pandi E, Fonyad G, Toth K, Jeney A: Putative role of dihydropyrimidine dehydrogenase in the toxic side effect of 5-fluorouracil in colorectal cancer patients. Oncology 1998;55:468-474.
    • (1998) Oncology , vol.55 , pp. 468-474
    • Katona, C.1    Kralovanszky, J.2    Rosta, A.3    Pandi, E.4    Fonyad, G.5    Toth, K.6    Jeney, A.7
  • 7
    • 0032795865 scopus 로고    scopus 로고
    • Life-threatening toxicity in a dihydropyrimidine dehydrogenase-deficient patient after treatment with topical 5-fluorouracil
    • Johnson MR, Hageboutros A, Wang K, High L, Smith JB, Diasio RB: Life-threatening toxicity in a dihydropyrimidine dehydrogenase-deficient patient after treatment with topical 5-fluorouracil. Clin Cancer Res 1999;5:2006-2011.
    • (1999) Clin Cancer Res , vol.5 , pp. 2006-2011
    • Johnson, M.R.1    Hageboutros, A.2    Wang, K.3    High, L.4    Smith, J.B.5    Diasio, R.B.6
  • 8
    • 0034488052 scopus 로고    scopus 로고
    • Clinical implications of dihydropyrimidine dehydrogenase (DPD) deficiency in patients with severe 5-fluorouracil-associated toxicity: Identification of new mutations in the DPD gene
    • van Kuilenburg AB, Haasjes J, Richel DJ, Zoetekouw L, Van Lenthe H, De Abreu RA, Maring JG, Vreken P, van Gennip AH: Clinical implications of dihydropyrimidine dehydrogenase (DPD) deficiency in patients with severe 5-fluorouracil-associated toxicity: identification of new mutations in the DPD gene. Clin Cancer Res 2000;6:4705-4712.
    • (2000) Clin Cancer Res , vol.6 , pp. 4705-4712
    • van Kuilenburg, A.B.1    Haasjes, J.2    Richel, D.J.3    Zoetekouw, L.4    Van Lenthe, H.5    De Abreu, R.A.6    Maring, J.G.7    Vreken, P.8    van Gennip, A.H.9
  • 9
    • 0034808681 scopus 로고    scopus 로고
    • Prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 50-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)-related toxicity compared with controls
    • Raida M, Schwabe W, Hausler P, Van Kuilenburg AB, Van Gennip AH, Behnke D, Hoffken K: Prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 50-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)-related toxicity compared with controls. Clin Cancer Res 2001;7:2832-2839.
    • (2001) Clin Cancer Res , vol.7 , pp. 2832-2839
    • Raida, M.1    Schwabe, W.2    Hausler, P.3    Van Kuilenburg, A.B.4    Van Gennip, A.H.5    Behnke, D.6    Hoffken, K.7
  • 10
    • 1942453306 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase and efficacy and toxicity of 5-fluorouracil
    • van Kuilenburg AB: Dihydropyrimidine dehydrogenase and efficacy and toxicity of 5-fluorouracil. Eur J Cancer 2004;40:939-950.
    • (2004) Eur J Cancer , vol.40 , pp. 939-950
    • van Kuilenburg, A.B.1
  • 11
    • 0030669252 scopus 로고    scopus 로고
    • A simple chromatographic method for the analysis of pyrimidines and their dehydrogenated metabolites
    • Gamelin E, Boisdron-Celle M, Larra F, Robert J: A simple chromatographic method for the analysis of pyrimidines and their dehydrogenated metabolites. J Liq Chrom Relat Technol 1997;20:3155-3172.
    • (1997) J Liq Chrom Relat Technol , vol.20 , pp. 3155-3172
    • Gamelin, E.1    Boisdron-Celle, M.2    Larra, F.3    Robert, J.4
  • 12
    • 0030755985 scopus 로고    scopus 로고
    • Rapid and sensitive liquid chromatographic analysis of halogenopyrimidines in plasma
    • Gamelin E, Boisdron-Celle M, Turcant A, Allain P, Robert J: Rapid and sensitive liquid chromatographic analysis of halogenopyrimidines in plasma. J Chromatogr B 1997;695:409-416.
    • (1997) J Chromatogr B , vol.695 , pp. 409-416
    • Gamelin, E.1    Boisdron-Celle, M.2    Turcant, A.3    Allain, P.4    Robert, J.5
  • 13
    • 33847731616 scopus 로고    scopus 로고
    • Common Toxicity Criteria. National Cancer Institute, version 2.0, April 30, 1999
    • Common Toxicity Criteria. National Cancer Institute, version 2.0, April 30, 1999.
  • 15
    • 0027426408 scopus 로고
    • Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: Population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy
    • Lu ZH, Zhang RW, Robert BD: Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy. Cancer Res 1993;53:5433-5438.
    • (1993) Cancer Res , vol.53 , pp. 5433-5438
    • Lu, Z.H.1    Zhang, R.W.2    Robert, B.D.3
  • 17
    • 0032745499 scopus 로고    scopus 로고
    • Relationship between intratumoral dihydropyrimidine dehydrogenase activity and gene expression in human colorectal cancer
    • Uetake H, Ichikawa W, Takechi T, Fukushima M, Nihei Z, Sugihara K: Relationship between intratumoral dihydropyrimidine dehydrogenase activity and gene expression in human colorectal cancer. Clin Cancer Res 1999;5:2836-2839.
    • (1999) Clin Cancer Res , vol.5 , pp. 2836-2839
    • Uetake, H.1    Ichikawa, W.2    Takechi, T.3    Fukushima, M.4    Nihei, Z.5    Sugihara, K.6
  • 18
    • 0032940053 scopus 로고    scopus 로고
    • Correlation between uracil and dihydrouracil plasma ratio, fluorouracil (5-FU) pharmacokinetic parameters, and tolerance in patients with advanced colorectal cancer: A potential interest for predicting 5-FU toxicity and determining optimal 5-FU dosage
    • Gamelin E, Boisdron-Celle M, Guerin-Meyer V, Delva R, Lortholary A, Genevieve F, Larra F, Ifrah N, Robert J: Correlation between uracil and dihydrouracil plasma ratio, fluorouracil (5-FU) pharmacokinetic parameters, and tolerance in patients with advanced colorectal cancer: a potential interest for predicting 5-FU toxicity and determining optimal 5-FU dosage. J Clin Oncol 1999;17:1105-1110.
    • (1999) J Clin Oncol , vol.17 , pp. 1105-1110
    • Gamelin, E.1    Boisdron-Celle, M.2    Guerin-Meyer, V.3    Delva, R.4    Lortholary, A.5    Genevieve, F.6    Larra, F.7    Ifrah, N.8    Robert, J.9
  • 19
    • 0025058867 scopus 로고
    • Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion
    • Harris BE, Song R, Soong SJ, Diasio RB: Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion. Cancer Res 1990;50:197-201.
    • (1990) Cancer Res , vol.50 , pp. 197-201
    • Harris, B.E.1    Song, R.2    Soong, S.J.3    Diasio, R.B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.