Recurrent thrombophlebitis in a colon cancer patient with C677T heterozygous genotype for MTHFR treated with 5-fluorouracil-based adjuvant chemotherapy

Chemotherapy

Volumn 50, Issue 4, 2004, Pages 194-195

  Schiavon, Gaia ^a   Vincenzi, Bruno ^a,c   Santini, Daniele ^a   Avvisati, Giuseppe ^b   Tonini, Giuseppe ^a  

^a Medical Oncology   (Italy)

^b Haematology   (Italy)

^c UNIVERSITY CAMPUS BIO MEDICO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; ENOXAPARIN; FLUOROURACIL; FOLINIC ACID; LOW MOLECULAR WEIGHT HEPARIN;

ADJUVANT CHEMOTHERAPY; AGED; ANAMNESIS; ANTICOAGULANT THERAPY; ARTICLE; CASE REPORT; CLINICAL FEATURE; COLON CANCER; DIAGNOSTIC PROCEDURE; FEMALE; FOLLOW UP; GENOTYPE; HETEROZYGOTE; HUMAN; PRIORITY JOURNAL; RECURRENT DISEASE; THROMBOPHLEBITIS; TREATMENT OUTCOME;

AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHEMOTHERAPY, ADJUVANT; COLONIC NEOPLASMS; FLUOROURACIL; GENOTYPE; HUMANS; LEUCOVORIN; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); RISK FACTORS; THROMBOPHLEBITIS;

EID: 8344245311     PISSN: 00093157     EISSN: None     Source Type: Journal    
DOI: 10.1159/000081031     Document Type: Article

References (7)

1. Wils J, O'Dwyer P, Labianca R: Adjuvant treatment of colorectal cancer at the turn of the century: European and US perspectives. Ann Oncol 2001;12:13-22.
2. Moehler M, Gutzler F, Steinmann S, et al: Comparison of a 48-hour infusion of 5-fluorouracil without folinic acid with 24-hour folinic acid/5-fluorouracil in patients with metastatic colorectal cancer refractory to bolus folinic acid/5-fluorouracil. A prospective cohort study. Chemotherapy 2003;49:85-89.
3. Toffoli G, Veronesi A, Boiocchi M, Crivellari D: MTHFR gene polymorphism and severe toxicity during adjuvant treatment of early breast cancer with cyclophosphamide, methotrexate, and fluorouracil (CMF). Ann Oncol 2000;11:373-374.
4. Friso S, Choi SW, Girelli D, et al: A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci USA 2002;99:5606-5611.
5. Botto LD, Yang Q: 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: A HuGE review. Am J Epidemiol 2000;151:862-877.
6. Geisler J, Geisler SB, Lonning PE, et al: Changes in folate status as determined by reduction in total plasma homocysteine levels during leucovorin modulation of 5-fluorouracil therapy in cancer patients. Clin Cancer Res 1998;4:2125-2128.
7. Brown MC: An adverse interaction between warfarin and 5-fluorouracil: A case report and review of the literature. Chemotherapy 1999;45:392-395.