Evaluation of cardiovascular effect of total intravenous anesthesia with propofol or a combination of ketamine-medetomidine-propofol in horses

American Journal of Veterinary Research

Volumn 68, Issue 2, 2007, Pages 121-127

  Umar, Muhammad A ^a   Yamashita, Kazuto ^a   Kushiro, Tokiko ^a,c   Muir III, William W ^b  

^a RAKUNO GAKUEN UNIVERSITY   (Japan)

^b OHIO STATE UNIVERSITY   (United States)

^c WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KETALAR 100; KETAMINE; MEDETOMIDINE; MIDAZOLAM; MIDAZOLAM MALEATE; PROPOFOL; UNCLASSIFIED DRUG; INTRAVENOUS ANESTHETIC AGENT;

ANESTHETIC RECOVERY; ARTERIAL PRESSURE; ARTICLE; ARTIFICIAL VENTILATION; BREATHING RATE; CARDIOVASCULAR EFFECT; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; DRUG INFUSION; DRUG MECHANISM; FEMALE; HEART INDEX; HEART RATE; HEART STROKE VOLUME; HORSE; INTRAVENOUS ANESTHESIA; LIMB MOVEMENT; LOADING DRUG DOSE; NONHUMAN; SCORING SYSTEM; SYSTEMIC VASCULAR RESISTANCE; ANIMAL; ANIMAL DISEASE; BLOOD PRESSURE; BREATHING; CLINICAL TRIAL; DRUG COMBINATION; DRUG EFFECT;

ANIMALIA; EQUIDAE;

ANESTHESIA, INTRAVENOUS; ANESTHETICS, INTRAVENOUS; ANIMALS; BLOOD PRESSURE; DRUG THERAPY, COMBINATION; FEMALE; HEART RATE; HORSES; KETAMINE; MEDETOMIDINE; PROPOFOL; RESPIRATION;

EID: 33847682239     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.68.2.121     Document Type: Article

References (36)

1. Steffey EP, Howland D Jr. Comparison of circulatory and respiratory effects of isoflurane and halothane anaesthesia in horses. Am J Vet Res 1980;41:821-825.
2. Bettschart-Wolfensberger R, Bowen MI, Freeman SL, et al. Cardiopulmonary effects of prolonged anesthesia via propofol-medetomidine infusion in ponies. Am J Vet Res 2001;62:1428-1435.
3. Bettschart-Wolfensberger R, Bowen MI, Freeman SL, et al. Medetomidine-ketamine anaesthesia induction followed by medetomidine-propofol in ponies: infusion rates and cardiopulmonary side effects. Equine Vet J 2003;35:308-313.
4. Mama KR, Wagner AE, Steffey EP, et al. Evaluation of xylazine and ketamine for total intravenous anesthesia in horses. Am J Vet Res 2005;66:1002-1007.
5. Taylor PM, Clarke KW. Intravenous anaesthesia. In: Handbook of equine anaesthesia. London: WB Saunders Co, 1999;33-54.
6. Taylor PM, Luna SP. Total intravenous anesthesia in ponies using detomidine, ketamine and guaiphenesin: pharmacokinetics, cardiopulmonary and endocrine effects. Res Vet Sci 1995;59:17-22.
7. Green SA, Thurmon JC, Tranquilli WJ, et al. Cardiopulmonary effects of continuous intravenous infusion of guaifenesin, ketamine, and xylazine in ponies. Am J Vet Res 1986;47:2364-2367.
8. Bettschart-Wolfensberger R, Kalchofner K, Neges K, et al. Total intravenous anesthesia in horses using medetomidine and propofol. Vet Anaesth Analg 2005;32:348-354.
9. White PF. Propofol. In: White PF, ed. Textbook of intravenous anesthesia. London: The Williams & Wilkins Co, 1997;111-152.
10. Bettschart-Wolfensberger R, Freeman SL, Jaggin-Schmucker N, et al. Infusion of a combination of propofol and medetomidine for long-term anesthesia in ponies. Am J Vet Res 2001;62:500-507.
11. Nolan AM, Hall LW. Total intravenous anaesthesia in the horse with propofol. Equine Vet J 1985;17:394-398.
12. Mama KR, Steffey EP, Pascoe PJ. Evaluation of propofol as a general anesthetic for horses. Vet Surg 1995;24:188-194.
13. Mama KR, Pascoe PJ, Steffey EP, et al. Comparison of two techniques for total intravenous anesthesia in horses. Am J Vet Res 1998;59:1292-1298.
14. Flaherty D, Reid J, Welsh F, et al. A pharmacodynamic study of propofol or propofol and ketamine in ponies undergoing surgery Res Vet Sci 1997;62:179-184.
15. Umar MA, Yamashita K, Kushiro T, et al. Evaluation of total intravenous anesthesia with propofol or ketamine-medetomidine-propofol combination in horses. J Am Vet Med Assoc 2006;228:1221-1227.
16. Muir WW, Skarda RT, Milne DW. Estimation of cardiac output in the horse by thermodilution techniques. Am J Vet Res 1976;37:697-700.
17. Bonagura JD, Muir WW. The cardiovascular system. In: Muir WW Hubbell JAE, eds. Equine anesthesia: monitoring and emergency therapy. St Louis: Mosby Year Book Inc, 1991;39-104.
18. Young SS, Taylor PM. Factors influencing the outcome of equine anaesthesia: a review of 1,314 cases. Equine Vet J 1993;25:147-151.
19. Grosenbaugh DA, Muir WW. Cardiorespiratory effects of sevoflurane, isoflurane, and halothane anesthesia in horses. Am J Vet Res 1998;59:101-106.
20. Mizuno Y, Aida H, Hara H, et al. Comparison of methods of cardiac output measurements determined by dye dilution, pulsed Doppler echocardiography and thermodilution in horses. J Vet Med Sci 1994;56:1-5.
21. Young LE, Blissitt KJ, Bartram DH, et al. Measurement of cardiac output by transoesophageal Doppler echocardiography in anaesthetized horses: comparison with thermodilution. Br J Anaesth 1996;77:773-780.
22. 2 adrenoceptor agonists in the horse - a review. Br Vet J 1996;152:641-657.
23. Yamashita K, Tsubakishita S, Futaoka S, et al. Cardiovascular effects of medetomidine, detomidine and xylazine in horses. J Vet Med Sci 2000;62:1025-1032.
24. Yamashita K, Satoh M, Umikawa A, et al. Combination of continuous intravenous infusion using a mixture of guaifenesin-ketamine-medetomidine and sevoflurane anesthesia in horses. J Vet Med Sci 2000;62:229-235.
25. Kushiro T, Yamashita K, Umar MA, et al. Anesthetic and cardiovascular effects of balanced anesthesia using constant infusion of midazolam-ketamine-medetomidine with inhalation of oxygen-sevoflurane (MKM-OS) in horses. J Vet Med Sci 2005;67:379-384.
26. Bentley GN, Gent JP, Goodchild CS. Vascular effects of propofol: smooth muscle relaxation in isolated veins and arteries. J Pharm Pharmacol 1989;41:797-798.
27. Ivankovitch AD, Milletich DJ, Reinmann C, et al. Cardiopulmonary effects of centrally administered ketamine in goats. Anesth Analg 1974;53:924-933.
28. Muir WW, Skarda RT, Mime DW. Evaluation of xylazine and ketamine hydrochloride for anesthesia in horses. Am J Vet Res 1977;38:195-201.
29. Bettschart-Wolfensberger R, Taylor PM, Sear JW, et al. Physiologic effects of anesthesia induced and maintained by intravenous administration of a climazolam-ketamine combination in ponies premedicated with acepromazine and xylazine. Am J Vet Res 1996;57:1472-1477.
30. Daunt DA, Dunlop CI, Chapman PL, et al. Cardiopulmonary and behavioral responses to computer-driven infusion of detomidine in standing horses. Am J Vet Res 1993;54:2075-2082.
31. Hubbell JAE, Bednarski RM, Muir WW. Xylazine and tiletamine-zolazepam anesthesia in horses. Am J Vet Res 1989;50:737-742.
32. Matthews NS, Hartsfield SM, Hague B, et al. Detomidine-propofol anesthesia for abdominal surgery in horses. Vet Surg 1999;28:196-201.
33. Lee YH, Clarke KW, Alibhai HI, et al. Effects of dopamine, dobutamine, dopexamine, phenylephrine, and saline on intramuscular blood flow and other cardiopulmonary variables in halothane-anesthetized ponies. Am J Vet Res 1998;59: 1463-1472.
34. Muir WW. Complications: induction, maintenance, and recovery phases of anesthesia. In: Muir WW, Hubbell JAE, eds. Equine anesthesia: monitoring and emergency therapy. St Louis: Mosby Year Book Inc, 1991;419-443.
35. Nolan AM, Reid J, Welsh E, et al. Simultaneous infusions of propofol and ketamine in ponies premedicated with detomidine: a pharmacokinetic study. Res Vet Sci 1996;60:262-266.
36. Nolan AM, Reid J. Pharmacokinetics of propofol administered by infusion in dogs undergoing surgery. Br J Anaesth 1993;70:546-551.