Coproduction of novel 16S rRNA methylase RmtD and metallo-β-lactamase SPM-1 in a panresistant Pseudomonas aeruginosa isolate from Brazil

Antimicrobial Agents and Chemotherapy

Volumn 51, Issue 3, 2007, Pages 852-856

  Doi, Yohei ^a   De Oliveira Garcia, Doroti ^b   Adams, Jennifer ^a   Paterson, David L ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b INSTITUTO ADOLFO LUTZ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

4,6 DEOXYSTREPTAMINE AMINOGLYCOSIDE DERIVATIVE; AMIKACIN; AMINOGLYCOSIDE; AMINOGLYCOSIDE DERIVATIVE; APRAMYCIN; BACTERIAL ENZYME; BETA LACTAM ANTIBIOTIC; GENTAMICIN; HABEKACIN; METALLO BETA LACTAMASE; METALLO BETA LACTAMASE SPM 1; NEOMYCIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RNA 16S; RNA METHYLTRANSFERASE; RNA METHYLTRANSFERASE RMTD; STREPTOMYCIN; TOBRAMYCIN; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY DISK DIFFUSION TEST; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BRAZIL; CONTROLLED STUDY; DRUG SENSITIVITY; ENZYME SYNTHESIS; HUMAN; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RMTA GENE; RMTD GENE; SOUTH AMERICA;

AMINO ACID SEQUENCE; AMINOGLYCOSIDES; BETA-LACTAMASES; BRAZIL; CARBAPENEMS; CLONING, MOLECULAR; DRUG RESISTANCE, MULTIPLE, BACTERIAL; METHYLTRANSFERASES; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PLASMIDS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS;

EID: 33847680076     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.01345-06     Document Type: Article

References (27)

1. American Thoracic Society and Infectious Diseases Society of America. 2005. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am. J. Respir. Crit. Care Med. 171:388-416.
2. Beauclerk, A. A., and E. Cundliffe. 1987. Sites of action of two ribosomal RNA methylases responsible for resistance to aminoglycosides. J. Mol. Biol. 193:661-671.
3. Bonomo, R. A., and D. Szabo. 2006. Mechanisms of multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa. Clin. Infect. Dis. 43(Suppl. 2):S49-S56.
4. Clinical and Laboratory Standards Institute. 2006. Performance standards for antimicrobial susceptibility testing; 16th informational supplement. CLSI document M100-S16. Clinical and Laboratory Standards Institute, Wayne, Pa.
5. Doi, Y., K. Yokoyama, K. Yamane, J. Wachino, N. Shibata, T. Yagi, K. Shibayama, H. Kato, and Y. Arakawa. 2004. Plasmid-mediated 16S rRNA methylase in Serratia marcescens conferring high-level resistance to aminoglycosides. Antimicrob. Agents Chemother. 48:491-496.
6. Gales, A. C., L. C. Menezes, S. Silbert, and H. S. Sader. 2003. Dissemination in distinct Brazilian regions of an epidemic carbapenem-resistant Pseudomonas aeruginosa producing SPM metallo-β-lactamase. J. Antimicrob. Chemother. 52:699-702.
7. Galimand, M., P. Courvalin, and T. Lambert. 2003. Plasmid-mediated high-level resistance to aminoglycosides in Enterobacteriaceae due to 16S rRNA methylation. Antimicrob. Agents Chemother. 47:2565-2571.
8. Galimand, M., S. Sabtcheva, P. Courvalin, and T. Lambert. 2005. Worldwide disseminated armA aminoglycoside resistance methylase gene is borne by composite transposon Tn1548. Antimicrob. Agents Chemother. 49:2949-2953.
9. Gonzalez-Zorn, B., A. Catalan, J. A. Escudero, L. Dominguez, T. Teshager, C. Porrero, and M. A. Moreno. 2005. Genetic basis for dissemination of armA. J. Antimicrob. Chemother. 56:583-585.
10. Kado, C. I., and S. T. Liu. 1981. Rapid procedure for detection and isolation of large and small plasmids. J. Bacteriol. 145:1365-1373.
11. Lee, H. D. Yong, J. H. Yum, K. H. Roh, K. Lee, K. Yamane, Y. Arakawa, and Y. Chong. 2006. Dissemination of 16S rRNA methylase-mediated highly amikacin-resistant isolates of Klebsiella pneumoniaeand Acinetobacter haumannii in Korea. Diagn. Microbiol. Infect. Dis. 56:305-312.
12. Liou, G. F., S. Yoshizawa, P. Courvalin, and M. Galimand. 2006. Aminoglycoside resistance by ArmA-mediated ribosomal 16S methylation in human bacterial pathogens. J. Mol. Biol. 359:358-364.
13. Micek, S. T., A. E. Lloyd, D. J. Ritchie, R. M. Reichley, V. J. Fraser, and M. H. Kollef. 2005. Pseudomonas aeruginosa bloodstream infection: importance of appropriate initial antimicrobial treatment. Antimicrob. Agents Chemother. 49:1306-1311.
14. Paterson, D. L. 2006. The epidemiological profile of infections with multidrug-resistant Pseudomonas aeruginosa and Acinetobacter species. Clin. Infect. Dis. 43(Suppl. 2):S43-S48.
15. Takaya, A., M. Watanabe, and T. Yamamoto. 2006. Organization of Tn2610 containing two transposition modules. Antimicrob. Agents Chemother. 50:1143-1147.
16. Tavakoli, N., A. Comanducci, H. M. Dodd, M. C. Lett, B. Albiger, and P. Bennett. 2000. IS1294, a DNA element that transposes by RC transposition. Plasmid 44:66-84.
17. Toleman, M. A., P. M. Bennett, and T. R. Walsh. 2006. Common regions e.g. iorf513 and antibiotic resistance: IS91-like elements evolving complex class 1 integrons. J. Antimicrob. Chemother. 58:1-6.
18. Toleman, M. A., P. M. Bennett, and T. R. Walsh. 2006. ISCR elements: novel gene-capturing systems of the 21st century? Microbiol. Mol. Biol Rev. 70:296-316.
19. Toleman, M. A., K. Rolston, R. N. Jones, and T. R. Walsh. 2003. Molecular and biochemical characterization of OXA-45, an extended-spectrum class 2d7prime; β-lactamase in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 47:2859-2863.
20. Trevors, J. T. 1986. Plasmid curing in bacteria. FEMS Microbiol. Rev. 32:149-157.
21. Wachino, J., K. Yamane, K. Kimura, N. Shibata, S. Suzuki, Y. Ike, and Y. Arakawa. 2006. Mode of transposition and expression of 16S rRNA methyltransferase gene rmtC accompanied by ISEcp1. Antimicrob. Agents Chemother. 50:3212-3215.
22. Wachino, J., K. Yamane, K. Shibayama, H. Kurokawa, N. Shibata, S. Suzuki, Y. Doi, K. Kimura, Y. Ike, and Y. Arakawa. 2006. Novel plasmid-mediated 16S rRNA methylase, RmtC, found in a Proteus mirabilis isolate demonstrating extraordinary high-level resistance against various aminoglycosides. Antimicrob. Agents Chemother. 50:178-184.
23. Yamane, K., Y. Doi, K. Yokohama, T. Yagi, H. Kurokawa, N. Shibata, K. Shibayama, H. Kato, and Y. Arakawa. 2004. Genetic environments of the rmtA gene in Pseudomonas aeruginosa clinical isolates. Antimicrob. Agents Chemother. 48:2069-2074.
24. Yamane, K., J. Wachino, Y. Doi, H. Kurokawa, and Y. Arakawa. 2005. Global spread of multiple aminoglycoside resistance genes. Emerg. Infect. Dis. 11:951-953.
25. Yan, J. J., J. J. Wu, W. C. Ko, S. H. Tsai, C. L. Chuang, H. M. Wu, Y. J. Lu, and J. D. Li. 2004. Plasmid-mediated 16S rRNA methylases conferring high-level aminoglycoside resistance in Escherichia coli and Klebsiella pneumoniae isolates from two Taiwanese hospitals. J. Antimicrob. Chemother. 54:1007-1012.
26. Yokoyama, K., Y. Doi, K. Yamane, H. Kurokawa, N. Shibata, K. Shibayama, T. Yagi, H. Kato, and Y. Arakawa. 2003. Acquisition of 16S rRNA methylase gene in Pseudomonas aeruginosa. Lancet 362:1888-1893.
27. Zavascki, A. P., P. B. Gaspareto, A. F. Martins, A. L. Goncalves, and A. L. Barth. 2005. Outbreak of carbapenem-resistant Pseudomonas aeruginosa producing SPM-1 metallo-β-lactamase in a teaching hospital in southern Brazil. J. Antimicrob. Chemother. 56:1148-1151.