Lower expression of catalytic and structural subunits of the proteasome contributes to decreased proteolysis in peripheral blood T lymphocytes during aging

International Journal of Biochemistry and Cell Biology

Volumn 39, Issue 4, 2007, Pages 799-809

  Ponnappan, Subramaniam ^a   Ovaa, Huib ^c   Ponnappan, Usha ^a,b  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

^c NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

Aging; Carbonylation; Lipid peroxidation; Proteasome; T lymphocytes

Indexed keywords

AGING; ARTICLE; CARBONYLATION; CELL LYSATE; ENZYME ACTIVITY; ENZYME DEGRADATION; HUMAN; HUMAN CELL; IMMUNE SYSTEM; LIPID PEROXIDATION; PROTEIN DEGRADATION; PROTEIN FUNCTION; T LYMPHOCYTE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; AGED; AGED, 80 AND OVER; AGING; BINDING SITES; BLOTTING, WESTERN; CATALYSIS; CATALYTIC DOMAIN; CELLS, CULTURED; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; JURKAT CELLS; LIPID PEROXIDATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN CARBONYLATION; PROTEIN SUBUNITS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES;

EID: 33847636678     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2007.01.002     Document Type: Article

References (24)

1. Berkers C.R., Verdoes M., Lichtman E., Fiebiger E., Kessler B.M., Anderson K.C., et al. Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib. Nature Methods 2 (2005) 357-362
2. Bulteau A.L., Lundberg K.C., Humphries K.M., Sadek H.A., Szweda P.A., Friguet B., et al. Oxidative modification and inactivation of the proteasome during coronary occlusion/reperfusion. The Journal of Biological Chemistry 276 (2001) 30057-30063
3. Bulteau A.L., Petropoulos I., and Friguet B. Age-related alterations of proteasome structure and function in aging epidermis. Experimental Gerontology 35 (2000) 767-777
4. Carrard G., Dieu M., Raes M., Toussaint O., and Friguet B. Impact of ageing on proteasome structure and function in human lymphocytes. The International Journal of Biochemistry and Cell Biology 35 (2003) 728-739
5. Chondrogianni N., and Gonos E.S. Proteasome inhibition induces a senescence-like phenotype in primary human fibroblasts cultures. Biogerontology 5 (2004) 55-61
6. Ciechanover A. Proteolysis: From the lysosome to ubiquitin and the proteasome. Nature Reviews Molecular Cell Biology 6 (2005) 79-87
7. Claverol S., Burlet-Schiltz O., Girbal-Neuhauser E., Gairin J.E., and Monsarrat B. Mapping and structural dissection of human 20 S proteasome using proteomic approaches. Molecular and Cellular Proteomics 1 (2002) 567-578
8. Davies K.J. Degradation of oxidized proteins by the 20S proteasome. Biochimie 83 (2001) 301-310
9. Ding Q., Dimayuga E., and Keller J.N. Proteasome regulation of oxidative stress in aging and age-related diseases of the CNS. Antioxidants and Redox Signaling 8 (2006) 163-172
10. Ferrington D.A., Husom A.D., and Thompson L.V. Altered proteasome structure, function, and oxidation in aged muscle. The FASEB Journal 19 (2005) 644-646
11. Grune T., Merker K., Jung T., Sitte N., and Davies K.J. Protein oxidation and degradation during postmitotic senescence. Free Radical Biology and Medicine 39 (2005) 1208-1215
12. Grune T., Reinheckel T., and Davies K.J. Degradation of oxidized proteins in mammalian cells. The FASEB Journal 11 (1997) 526-534
13. Haynes L., and Swain S.L. Why aging T cells fail: Implications for vaccination. Immunity 24 (2006) 663-666
14. Husom A.D., Peters E.A., Kolling E.A., Fugere N.A., Thompson L.V., and Ferrington D.A. Altered proteasome function and subunit composition in aged muscle. Archives of Biochemistry and Biophysics 421 (2004) 67-76
15. Lecker S.H., Goldberg A.L., and Mitch W.E. Protein degradation by the ubiquitin-proteasome pathway in normal and disease states. Journal of the American Society of Nephrology 17 (2006) 1807-1819
16. Levine R.L., Williams J.A., Stadtman E.R., and Shacter E. Carbonyl assays for determination of oxidatively modified proteins. Methods in Enzymology 233 (1994) 346-357
17. Okada K., Wangpoengtrakul C., Osawa T., Toyokuni S., Tanaka K., and Uchida K. 4-Hydroxy-2-nonenal-mediated Impairment of Intracellular Proteolysis during Oxidative Stress. Identification of proteasomes as target molecules. The Journal of Biological Chemistry 274 (1999) 23787-23793
18. Park Y., Hwang Y.P., Lee J.S., Seo S.H., Yoon S.K., and Yoon J.B. Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases. Molecular and Cellular Biology 25 (2005) 3842-3853
19. Ponnappan S., Cullen S.J., and Ponnappan U. Constitutive degradation of IkappaBalpha in human T lymphocytes is mediated by calpain. Immunity and Ageing 2 (2005) 15
20. Ponnappan S., and Ponnappan U. Age-related alteration in proteasomal subunits may underlie decline in activity during aging. 12th International Congress of Immunology and 4th Annual Conference of FOCIS. Montreal, Canada, July 18-23 (2004), Medimond, Bologna, Italy 171-175
21. Ponnappan U., Zhong M., and Trebilcock G.U. Decreased proteasome-mediated degradation in T cells from the elderly: A role in immune senescence. Cellular Immunology 192 (1999) 167-174
22. Poppek D., and Grune T. Proteasomal defense of oxidative protein modifications. Antioxidants and Redox Signaling 8 (2006) 173-184
23. Rock K.L., and Goldberg A.L. Degradation of cell proteins and the generation of MHC class I-presented peptides. Annual Review of Immunology 17 (1999) 739-779
24. Rozen S., and Skaletsky H.J. Primer 3 on the WWW for general users and for biologist programmers. In: Krawetz S., and Misener S. (Eds). Bioinformatics methods and protocols: Methods in molecular biology (2000), Humana Press, Totowa, NJ 365-386