Effect of post-exposure administration of keratinocyte growth factor (Palifermin) on radiation effects in oral mucosa in mice

Radiation and Environmental Biophysics

Volumn 46, Issue 1, 2007, Pages 13-19

  Kiliç, Yasemin ^a   Rajewski, Katja ^a   Dörr, Wolfgang ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

KERATINOCYTE GROWTH FACTOR; ORAL MUCOSITIS; RADIATION EXPOSURE; ULCERATION;

DISEASES; GROWTH KINETICS; IRRADIATION; PROTEINS; X RAY ANALYSIS;

RADIATION EFFECTS;

KERATINOCYTE GROWTH FACTOR; PALIFERMIN; RECOMBINANT KERATINOCYTE GROWTH FACTOR;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; FOLLOW UP; MALE; MOUSE; MOUTH MUCOSA; MUCOSA INFLAMMATION; NONHUMAN; RADIATION DOSE; RADIATION EXPOSURE; SINGLE DRUG DOSE; STATISTICAL SIGNIFICANCE; TONGUE; X IRRADIATION;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; FIBROBLAST GROWTH FACTOR 7; MALE; MICE; MOUTH MUCOSA; STOMATITIS;

ANIMALIA; MUS;

EID: 33847625886     PISSN: 0301634X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00411-006-0079-7     Document Type: Article

References (21)

1. Rubin JS, Bottaro DB, Chedid M, Miki T, Ron D, Cheon HG, Taylor WG, Fortney E, Sakata H, Finch PW, La Rochelle WJ (1995) Keratinocyte growth factor. Cell Biol Int 19:399-411
2. Farrell CL, Rex KL, Chen JN, Bready JV, Dipalma CR, Kaufman SA, Rattan A, Scully S, Lacey DL (2002) The effects of keratinocyte growth factor in preclinical models of mucositis. Cell Prolif 35(Suppl 1):1-8
3. Werner S (1998) Keratinocyte growth factor: a unique player in epithelial repair processes. Cytokine Growth Factor Rev 9:153-165
4. Danilenko DM (1999) Preclinical and early clinical development of keratinocyte growth factor, an epithelial-specific tissue growth factor. Toxicol Pathol 27:64-71
5. Dörr W (2003) Oral mucosa: response modification by keratinocyte growth factor. In: Nieder C, Milas L, Ang KK (eds) Biological modification of radiation response. Springer, Berlin Heidelberg New York, pp 113-122
6. Dörr W, Noack R, Spekl K, Farrell CL (2001) Modification of oral mucositis by keratinocyte growth factor: single radiation exposure. Int J Radiat Biol 77:341-347
7. Dörr W, Spekl K, Farell CL (2002) The effect of keratinocyte growth factor on healing of manifest radiation ulcers in mouse tongue epithelium. Cell Prolif 35:86-92
8. Dörr W, Heider K, Spekl K (2005) Reduction of oral mucositis by palifermin (rHuKGF): dose-effect of rHuKGF. Int J Radiat Biol 81(8):557-565
9. Dörr W, Brankovic K, Hartmann B (2000) Repopulation in mouse oral mucosa: changes in the effect of dose fractionation. Int J Radiat Biol 76:383-390
10. SAS Institute INC (1990a) SAS/STAT user's guide, version 6. SAS Institute, Cary
11. SAS Institute INC (1990b) SAS/STAT user's guide, version 6. SAS Institute, Cary, pp 892-906
12. SAS Institute INC (1990c) SAS/STAT user's guide, version 6. SAS Institute, Cary, pp 1324-1350
13. Dörr W, Emmendörfer H, Weber-Frisch M (1996) Tissue kinetics in mouse during daily fractionated radiotherapy. Cell Prolif 29:495-504
14. Liu K, Kasper M, Trott KR (1996) Changes in keratinocyte differentiation during accelerated repopulation of the irradiated mouse epidermis. Int J Radiat Biol 69:763-769
15. Van Der Schueren E, Van Den Bogaert W, Vanuystel L, Van Limbergen E (1990) Radiotherapy by multiply fractions per day (MFD) in head and neck cancer: acute reactions of skin and mucosa. Int J Radiat Oncol Biol Phys 19:301-311
16. Denham JW, Peters LJ, Johansen J, Pulsen M, Lamb DS, Hindley A, O'Brien PC, Spry NA, Penminent M, Krawitz H, Williamson S, Bear J, Tripcony L (1999) Do acute mucosal reactions lead to consequential late reactions patients with head and neck cancer? Radiother Oncol 52:157-164
17. Spielberger R, Stiff P, Bensinger W, Gentile T, Weisdorf D, Kewelramani T, Shea T, Yanowich S, Hansen K, Noga S, McCarty J, Lemaistre CF, Sung EC, Blazar BR, Elhardt D, Chen MG, Emmanouilides C (2004) Palifermin for oral mucositis after intensive therapy for hematologic cancers. N Engl J Med 351(25):2590-2598
18. Farrell CL, Rex KL, Kaufman SA, Di Palma CR, Chen JN, Scully S, Lacey DL (1999) Effects of keratinocyte growth factor in the squamous epithelium of the upper aerodigestive tract of normal and irradiated mice. Int J Radiat Biol 75:609-620
19. Dörr W (1997) Three A's of repopulation during fractionated irradiation in squamous epithelia: asymmetry loss, acceleration of stem- cell divisions and abortive divisions. Int J Radiat Biol 72:635-643
20. Dörr W (2003) Modulation of repopulation processes in oral mucosa: experimental results. Int J Radiat Biol 79:531-537
21. Klammt S (2005) Modification of oral mucositis (mouse) by keratinocyte growth factor (rHuKGF, Palifermin) after single radiation exposure: histological and immunhistochemical investigations. MDS Thesis. University of Technology, Dresden