Homocysteine, folic acid and B12 serum levels in pregnancy complicated with preeclampsia

Archives of Gynecology and Obstetrics

Volumn 275, Issue 2, 2007, Pages 121-124

  Makedos, Georgios ^a   Papanicolaou, Alexis ^a   Hitoglou, Areti ^a   Kalogiannidis, Ioannis ^a   Makedos, Anastasios ^a   Vrazioti, Violeta ^a   Goutzioulis, Michalis ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Folic acid; Homocystein; Preeclampsia; Pregnancy; Vitamin B12

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; CESAREAN SECTION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FETUS DEATH; FOLIC ACID BLOOD LEVEL; GESTATIONAL AGE; HUMAN; INTRAUTERINE GROWTH RETARDATION; PREECLAMPSIA; PREGNANCY; PROSPECTIVE STUDY; SOLUTIO PLACENTAE; STATISTICAL SIGNIFICANCE; VITAMIN BLOOD LEVEL;

ADULT; FEMALE; FOLIC ACID; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; PRE-ECLAMPSIA; PREDICTIVE VALUE OF TESTS; PREGNANCY; PREGNANCY OUTCOME; PROSPECTIVE STUDIES; RISK FACTORS; VITAMIN B 12;

EID: 33847618818     PISSN: 09320067     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00404-006-0223-2     Document Type: Article

References (23)

1. De Vries JLP, Dekker GA, Huijgens PC, Jakobs C, Bloomberg BME, Van Geijn HP (1997) Hyperhomocysteinemia and protein S deficiency in complicated pregnancies. Br J Obstet Gynecol 104:1248-1254
2. Dekker AG, DeVries JIP, Doelitzsch PM et al (1995) Underlying disorders associated with severe early onset preeclampsia. Am J Obstet Gynecol 173:1042-1048
3. Ray JG, Laskin CA (1999) Folic acid and homocyst(e)ine metabolic defects and the risk of placental abruption, preeclampsia and spontaneous pregnancy loss: a systematic review. Placenta 20:519-529
4. Domagala TB, Undas A, Libura M, Szezklick A (1998) Pathogenesis of vascular disease in hyperhomcysteinemia. J Cardiovasc Risk 5:239-247
5. Hague WM (2003) Homocysteine and pregnancy. Best Pract Res Clin Obstet Gynaecol 17:459-469
6. Aubard Y, Darodes N, Cantaloube M (2000) Hyperhomocysteinemia and pregnancy: review of our present understanding and therapeutic implications. Eur J Obstet Gynecol Reprod Biol 93:157-165
7. Van Pampus MG, Dekker CA, Wolf H et al (1999) High prevalence of haemostatic abnormalities in women with a history of severe preeclampsia. Am J Obstet Gynecol 180:1146-1150
8. Dekker AG, Morris NH (2001) Medical conditions associated with hypertensive disorders of pregnancy. In: Sibai BM (ed) Hypertensive disorders in women. W.B. Saunders, Philadelphia, p 85
9. Powers RW, Evans RW, Ness RB et al (2001) Homocysteine and cellular fibronectin are increased in preeclampsia, not transient hypertension of pregnancy. Hypertens Pregnancy 20:69-77
10. Baksu A, Taskin M, Goker N, Baksu B, Uluocak A (2006) Plasma homocysteine in late pregnancies complicated with preeclampsia and in newborns. Am J Perinatol 23:31-35
11. Maruotti G, Del Bianco A, Amato AN, Lomardi L, Fulgeri AM, Pietropaolo F (2005) Preeclampsia and high serum levels of homocysteine. Minerva Ginecol 57:165-170
12. Daly S, Cotter A, Molly AE, Scott J (2005) Homocysteine and folic acid: implications for pregnancy. Semin Vasc Med 5:190-200
13. Fayder MR, Yussef M, Odah MM (2004) Hyperhomocysteinemia is A risk marker for development of maternal preeclampsia. Boll Chim Farm 143:281-287
14. Fernandez M, Fernandez G, Diez-Ewald M et al (2005) Plasma homocysteine concentration and its relationship with the development of preeclampsia. Effects of prenatal administration of folic acid. Invest Clin 46:187-195
15. Ingec M, Borekci B, Kadanali S (2005) Elevated plasma homocysteine concentration in severe preeclampsia and eclampsia. Tohoku J Exp Med 206:225-231
16. Vollset SE, Refsum H, Irgens LM et al (2000) Plasma total homocysteine pregnancy complications and adverse pregnancy outcomes: the Hordaland Homocysteine study. Am J Clin Nutrit 71:962-968
17. Mignini L, Latthe P, Villar J, Kilby M, Carroli G, Khan K (2005) Mapping the theories of preeclampsia: the role of homocysteine. Obstet Gynecol 105:411-425
18. Hietala R, Turpeinen U, Laatikainen T (2001) Serum homocysteine at 16 weeks and subsequent preeclampsia. Obstet Gynecol 97:527-529
19. Cotter AM, Molloy M, Scott JM, Daly S (2003) Elevated plasma homocysteine in early pregnancy: a risk factor for the development of nonsevere preeclampsia. Am J Obstet Gynecol 189:391-396
20. Bolander-Gouaille C (2002) The homocysteine metabolism. In: Bolander-Gouaille C (ed) Focus on homocysteine and the vitamins. Springer, Paris, p 20
21. Leeda M, Riyazi N, de Vries JLI et al (1998) Effects of folic acid and vitamin B6 supplementation on women with hyperhomocysteinemia and a history of preeclampsia or fetal growth restriction. Am J Obstet Gynecol 179:135-139
22. Powers RW, Evans RW, Majors AK et al (1998) Plasma homocysteine concentration is increased in preeclampsia and is associated with evidence of endothelial activation. Am J Obstet Gynecol 179:1606-1611
23. Lachmeijer AM, Arnigrimsson R, Bastiaans EJ et al (2001) Mutation in the gene for methylenetetrahydrofolate reductase, homocysteine levels and vitamin status in women with history of preeclampsia. Am J Obstet Gynecol 184:394-402