The myeloid features of BXH2 leukemias may result from the lack of one copy of the repetitive sequence in the long terminal repeat viral enhancer [1]

International Journal of Hematology

Volumn 85, Issue 2, 2007, Pages 170-172

  Huang, Liqun ^a   Osato, Motomi ^a,b   Yanagida, Masatoshi ^b   Yamashita, Namiko ^b   Ito, Yoshiaki ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MYB; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR RUNX;

1CSBP1 GENE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; C57BL 6 MOUSE; ENHANCER REGION; GENE; GENE IDENTIFICATION; GENE MUTATION; IMMUNOPHENOTYPING; LETTER; LONG TERMINAL REPEAT; MOLONEY LEUKEMIA ONCOVIRUS; MOUSE; MOUSE STRAIN; MYELOID LEUKEMIA; NONHUMAN; NUCLEOTIDE REPEAT; NUCLEOTIDE SEQUENCE; ONCOGENE; PHENOTYPE; POLYMERASE CHAIN REACTION; RETROVIRAL INSERTIONAL MUTAGENESIS; RETROVIRUS; TECHNIQUE; TUMOR SUPPRESSOR GENE; VIRAL GENETICS; VIRUS GENE;

ANIMALS; BASE SEQUENCE; ENHANCER ELEMENTS (GENETICS); LEUKEMIA; MICE; MOLECULAR SEQUENCE DATA; RETROVIRIDAE; RETROVIRIDAE INFECTIONS; SEQUENCE DELETION; TERMINAL REPEAT SEQUENCES; TUMOR VIRUS INFECTIONS;

EID: 33847608887     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1532/IJH97.A20607     Document Type: Letter

References (6)

1. Bedigian HG, Johnson DA, Jenkins NA, Copeland NG, Evans R. Spontaneous and induced leukemias of myeloid origin in recombinant inbred BXH mice. J Virol. 1984;51:586-594.
2. Turcotte K, Gauthier S, Mitsos LM, et al. Genetic control of myeloproliferation in BXH-2 mice. Blood. 2004;103:2343-2350.
3. Turcotte K, Gauthier S, Tuite A, Mullick A, Malo D, Gros P. A mutation in the Icsbp1 gene causes susceptibility to infection and a chronic myeloid leukemia-like syndrome in BXH-2 mice. J Exp Med. 2005;201:881-890.
4. Yamashita N, Osato M, Huang L, et al. Haploinsufficiency of Runx1/AML1 promotes myeloid features and leukaemogenesis in BXH2 mice. Br J Haematol. 2005;131:495-507.
5. Sorensen KD, Quintanilla-Martinez L, Kunder S, Schmidt J, Pedersen FS. Mutation of all Runx (AML1/core) sites in the enhancer of T-lymphomagenic SL3-3 murine leukemia virus unmasks a significant potential for myeloid leukemia induction and favors enhancer evolution toward induction of other disease patterns. J Virol. 2004;78:13216-13231.
6. Bedigian HG, Shepel LA, Hoppe PC. Transplacental transmission of a leukemogenic murine leukemia virus. J Virol. 1993;67:6105-6109.