Curative effects of transplantation of hepatocytes differentiated from embryonic stem cells on treatment of fulminant hepatic failure: Experiment with mice

National Medical Journal of China

Volumn 86, Issue 46, 2006, Pages 3280-3284

  Hu, An Bin ^a   He, Xiao Shun ^a   Zheng, Qi Chang ^a   Cai, Ji Ye ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Cell transplantation; Differetiation; Embryonic stem cells; Fulminant hepatic failure; Hepatocytes

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALPHA FETOPROTEIN; BILIRUBIN; CARBON TETRACHLORIDE; CYTOKERATIN; CYTOKERATIN 11; CYTOKERATIN 8; GLUCOSE; GLUCOSE 6 PHOSPHATE; GREEN FLUORESCENT PROTEIN; HEPATOCYTE NUCLEAR FACTOR 3BETA; MESSENGER RNA; NUCLEAR FACTOR; PREALBUMIN; TYROSINE AMINOTRANSFERASE; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASCITES; BILIRUBIN BLOOD LEVEL; CELL CULTURE; CELL DIFFERENTIATION; CELL FUNCTION; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISEASE SEVERITY; EMBRYONIC STEM CELL; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; LIVER CELL; LIVER FAILURE; LIVER PARENCHYMA; LIVER STRUCTURE; MOUSE; MOUSE STRAIN; NONHUMAN; PROTEIN EXPRESSION; PROTHROMBIN TIME; QUALITY OF LIFE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL TRANSPLANTATION; SURVIVAL RATE; SURVIVAL TIME; TUMOR GROWTH;

ALBUMINS; ALPHA-FETOPROTEINS; ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; EMBRYONIC STEM CELLS; GENE EXPRESSION; GREEN FLUORESCENT PROTEINS; HEPATOCYTES; IMMUNOHISTOCHEMISTRY; LIVER FAILURE, ACUTE; MICE; MICROSCOPY, FLUORESCENCE; RANDOM ALLOCATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STEM CELL TRANSPLANTATION; SURVIVAL ANALYSIS; TRANSFECTION;

EID: 33847420140     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Nishimura F, Yoshikawa M, Kanda S, et al. Potential use of embryonic stem cells for the treatment of mouse parkinsonian models: improved behavior by transplantation of in vitro differentiated dopaminergic neurons from embryonic stem cells. Stem Cells, 2003, 21: 171-180.
2. Trounson AO. The derivation and potential use of human embryonic stem cells. Reprod Fertil Dev, 2001,13: 523-32.
3. Kobayashi N, Fujiwara T, Westerman KA, et al. Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes. Science, 2000,287: 1258-1262.
4. Strom SC, Chowdhury JR, and Fox IJ. Hepatocyte transplantation for the treatment of human disease. Semin. Liver Dis, 1999, 19: 39-48.
5. Fandrich F, Ruhnke M. Stem cells and liver replacement. Med Klin (Munich), 2003, 98(Suppl 2): 18-22.
6. Takashi Hamazaki, Yasuhiko Iiboshi, Masahiro Oka, et al. Hepatic maturation in differentiating embryonic stem cells in vitro. FEBS, 2001, 497: 15-19.
7. Jones EA, Tosh D, David I. Wilson et al. Hepatic differentiation of muring embryonic stem cells. Exp cell research, 2002, 272: 15-22.
8. Chinzei R, Tanaka Y, Shimizu-Saito K, et al. Embryoid-body cells derived from a mouse embryonic stem cell line show differentiation into functional hepatocytes. Hepatology, 2002, 36: 22-29.
9. Yamada T, Yoshikawa M, Kanda S, et al. In vitro differentiation of embryonic stem cells into hepatocyte-like cells identified by cellular uptake of indocyanine green. Stem cell, 2002,20: 146-154.
10. Chinese source.
11. Makover A, Soprano DR, Wyatt ML, et al. An in situ-hybridization study of the localization of retinol-binding protein and transthyretin messenger RNAs during fetal development in the rat. Differentiation, 1989,40: 17-25.
12. Sellem CH, Frain M, Erdos T. Differential expression of albumin and alpha-fetoprotein genes in fetal tissues of mouse and rat. Dev Biol, 1984,102: 51-60.
13. Monaghan AP, Kaestner KH, Grau E. Postimplantation expression patterns indicate a role for the mouse fork head/HNF-3 genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm. Development, 1993,119: 567-578.
14. Pan CJ, Lei KJ, Chen H, et al. Ontogeny of the murine glucose-6-phosphatase system. Arch. Biochem Biophys, 1998,358: 17-24.
15. Shelly LL, Tynan W, Schmid W, et al. Hepatocyte differentiation in vitro: initiation of tyrosine aminotransferase expression in cultured fetal rat hepatocytes. J Cell Biol, 1989,109: 3403-3410.
16. O'Shea KS. Embryonic stem cell models of development. The Anatomical Record, 1999, 257: 32-41.
17. Wiles MV. Embryonic stem cell differentiation in vitro. Methods Enzymol, 1995, 225: 900-918.