Induction of hepatic cytochrome P450 isoforms by nicardipine at therapeutic doses in spontaneously hypertensive rats

Journal of Toxicological Sciences

Volumn 32, Issue 1, 2007, Pages 79-90

  Miyajima, Shoji ^a   Nemoto, Kiyomitsu ^a   Sekimoto, Masashi ^a   Kinae, Yusuke ^a   Kasahara, Toshihiko ^a,b   Souma, Shinji ^a   Degawa, Masakuni ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b MOCHIDA PHARMACEUTICAL CO   (Japan)

Author keywords

CYP; Cytochrome P450; Drug therapy; Hypertension; Nicardipine; Rat liver

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2B; CYTOCHROME P450 3A; CYTOCHROME P450 3A4; DIHYDROPYRIDINE; MESSENGER RNA; NICARDIPINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG SAFETY; ENZYME ACTIVITY; HYPERTENSION; LIVER MICROSOME; MALE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; STATISTICAL ANALYSIS;

RATTUS;

ANIMALS; ANTIHYPERTENSIVE AGENTS; ARYL HYDROCARBON HYDROXYLASES; CALCIUM CHANNEL BLOCKERS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; GENE EXPRESSION; HYPERTENSION; MALE; NICARDIPINE; RATS; RATS, INBRED SHR;

EID: 33847396208     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.32.79     Document Type: Article

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