A combinatorial haplotype of the UDP-glucuronosyltransferase 1A1 gene (#60-#IB) increases total bilirubin concentrations in Japanese volunteers [2]

Clinical Chemistry

Volumn 53, Issue 2, 2007, Pages 356-358

  Saeki, Mayumi ^a   Saito, Yoshiro ^a   Sai, Kimie ^a   Maekawa, Keiko ^a   Kaniwa, Nahoko ^a   Sawada, Jun Ichi ^a   Kawamoto, Manabu ^b   Saito, Akira ^b   Kamatani, Naoyuki ^b  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; BIOLOGICAL MARKER; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A3;

3' UNTRANSLATED REGION; BILIRUBIN BLOOD LEVEL; CHROMOSOME ANALYSIS; COMBINATORIAL CHEMISTRY; CONCENTRATION (PARAMETERS); DNA FLANKING REGION; DNA POLYMORPHISM; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENOTYPE; GLUCURONIDATION; HAPLOTYPE; HUMAN; LETTER; STATISTICAL ANALYSIS;

BILIRUBIN; GENOTYPE; GLUCURONOSYLTRANSFERASE; HAPLOTYPES; HUMANS; JAPAN;

EID: 33847390750     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1373/clinchem.2006.077990     Document Type: Letter

References (5)

1. Kaplan M, Hammerman C. Bilirubin and the genome: the hereditary basis of unconjugated neonatal hyperbilirubinemia. Curr Pharmacogenomics 2005;3:21-42.
2. Sai K, Saeki M, Saito Y, Ozawa S, Katori N, Jinno H, et al. UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer. Clin Pharmacol Ther 2004;75:501-15.
3. Kaniwa N, Kurose K, Jinno H, Tanaka-Kagawa T, Saito Y, Saeki M, et al. Racial variability in haplotype frequencies of UGT1A1 and glucuronidation activity of a novel single nucleotide polymorphism 686C>T (P229L) found in an African-American. Drug Metab Dispos 2005;33:458-65.
4. Saeki M, Saito Y, Jinno H, Tohkin M, Kurose K, Kaniwa N, et al. Comprehensive UGT1A1 genotyping in a Japanese population by pyrosequencing. Clin Chem 2003;49:1182-5.
5. Saeki M, Saito Y, Jinno H, Sai K, Ozawa S, Kurose K, et al. Haplotype structures of the UGT1A gene complex in a Japanese population. Pharmacogenomics J 2006;6:63-75.