The BRCT domain of mammalian Pes1 is crucial for nucleolar localization and rRNA processing

Nucleic Acids Research

Volumn 35, Issue 3, 2007, Pages 789-800

  Ḧlzel, Michael ^a   Grimm, Thomas ^a   Rohrmoser, Michaela ^a   Malamoussi, Anastassia ^a   Harasim, Thomas ^a   Gruber Eber, Anita ^a   Kremmer, Elisabeth ^a   Eick, Dirk ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; CELL CYCLE PROTEIN; NUCLEAR PROTEIN; PROTEIN BOP1; PROTEIN PESCADILLO; PROTEIN WDR12; RIBOSOME RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; BIOGENESIS; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MUTANT; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; RNA PROCESSING;

CELL LINE, TUMOR; CELL NUCLEOLUS; HUMANS; NUCLEAR PROTEINS; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; PROTEINS; RNA INTERFERENCE; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, RIBOSOMAL; SEQUENCE DELETION;

MAMMALIA;

EID: 33847365771     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkl1058     Document Type: Article

References (39)

1. Jorgensen,P. and Tyers,M. (2004) How cells coordinate growth and division. Curr. Biol., 14, R1014-R1027.
2. Mayer,C., Bierhoff,H. and Grummt,I. (2005) The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis. Genes Dev., 19, 933-941.
3. Mayer,C. and Grummt,I. (2005) Cellular stress and nucleolar function. Cell Cycle, 4, 1036-1038.
4. Mayer,C., Zhao,J., Yuan,X. and Grummt,I. (2004) mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability. Genes Dev., 18, 423-434.
5. Sirri,V., Hernandez-Verdun,D. and Roussel,P. (2002) Cyclin-dependent kinases govern formation and maintenance of the nucleolus. J. Cell. Biol., 156, 969-981.
6. Voit,R., Hoffmann,M. and Grummt,I. (1999) Phosphorylation by G1-specific cdk-cyclin complexes activates the nucleolar transcription factor UBF. EMBO J., 18, 1891-1899.
7. Rubbi,C.P. and Milner,J. (2003) Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses. EMBO J., 22, 6068-6077.
8. Holzel,M., Rohrmoser,M., Schlee,M., Grimm,T., Harasim,T., Malamoussi,A., Gruber-Eber,A., Kremmer,E., Hiddemann,W., Bornkamm,G.W. et al. (2005) Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation. J. Cell. Biol., 170, 367-378.
9. Pestov,D.G., Strezoska,Z. and Lau,L.F. (2001) Evidence of p53-dependent cross-talk between ribosome biogenesis and the cell cycle: Effects of nucleolar protein Bop1 on G(1)/S transition. Mol. Cell. Biol., 21, 4246-4255.
10. Yuan,X., Zhou,Y., Casanova,E., Chai,M., Kiss,E., Grone,H.J., Schutz,G. and Grummt,I. (2005) Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis. Mol. Cell, 19, 77-87.
11. Lohrum,M.A., Ludwig,R.L., Kubbutat,M.H., Hanlon,M. and Vousden,K.H. (2003) Regulation of HDM2 activity by the ribosomal protein L11. Cancer Cell, 3, 577-587.
12. Dai,M.S. and Lu,H. (2004) Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5. J. Biol. Chem., 279, 44475-44482.
13. Jin,A., Itahana,K., O'Keefe,K. and Zhang,Y. (2004) Inhibition of HDM2 and activation of p53 by ribosomal protein L23. Mol. Cell. Biol., 24, 7669-7680.
14. Zhang,Y., Wolf,G.W., Bhat,K., Jin,A., Allio,T., Burkhart,W.A. and Xiong,Y. (2003) Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway. Mol. Cell. Biol., 23, 8902-8912.
15. Fatica,A. and Tollervey,D. (2002) Making ribosomes. Curr. Opin. Cell. Biol., 14, 313-318.
16. Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E., Lamond,A.I. and Mann,M. (2005) Nucleolar proteome dynamics. Nature, 433, 77-83.
17. Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H., Mann,M. and Lamond,A.I. (2002) Directed proteomic analysis of the human nucleolus. Curr. Biol., 12, 1-11.
18. Leung,A.K., Trinkle-Mulcahy,L., Lam,Y.W., Andersen,J.S., Mann,M. and Lamond,A.I. (2006) NOPdb: Nucleolar Proteome Database. Nucleic Acids Res., 34, D218-D220.
19. Lerch-Gaggl,A., Haque,J., Li,J., Ning,G., Traktman,P. and Duncan,S.A. (2002) Pescadillo is essential for nucleolar assembly, ribosome biogenesis, and mammalian cell proliferation. J. Biol. Chem., 277, 45347-45355.
20. Kinoshita,Y., Jarell,A.D., Flaman,J.M., Foltz,G., Schuster,J., Sopher,B.L., Irvin,D.K., Kanning,K., Kornblum,H.I., Nelson,P.S. et al. (2001) Pescadillo, a novel cell cycle regulatory protein abnormally expressed in malignant cells. J. Biol. Chem., 276, 6656-6665.
21. Grimm,T., Holzel,M., Rohrmoser,M., Harasim,T., Malamoussi,A., Gruber-Eber,A., Kremmer,E. and Eick,D. (2006) Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex. Nucleic Acids Res., 34, 3030-3043.
22. Lapik,Y.R., Fernandes,C.J., Lau,L.F. and Pestov,D.G. (2004) Physical and functional interaction between Pes1 and Bop1 in mammalian ribosome biogenesis. Mol. Cell, 15, 17-29.
23. Strezoska,Z., Pestov,D.G. and Lau,L.F. (2000) Bop1 is a mouse WD40 repeat nucleolar protein involved in 28S and 5.8S RRNA processing and 60S ribosome biogenesis. Mol. Cell. Biol., 20, 5516-5528.
24. Harnpicharnchai,P., Jakovljevic,J., Horsey,E., Miles,T., Roman,J., Rout,M., Meagher,D., Imai,B., Guo,Y., Brame,C.J. et al. (2001) Composition and functional characterization of yeast 66S ribosome assembly intermediates. Mol. Cell, 8, 505-515.
25. Miles,T.D., Jakovljevic,J., Horsey,E.W., Harnpicharnchai,P., Tang,L. and Woolford,J.L.,Jr (2005) Ytm1, Nop7, and Erb1 form a complex necessary for maturation of yeast 66S preribosomes. Mol. Cell. Biol., 25, 10419-10432.
26. Krogan,N.J., Peng,W.T., Cagney,G., Robinson,M.D., Haw,R., Zhong,G., Guo,X., Zhang,X., Canadien,V., Richards,D.P. et al. (2004) High-definition macromolecular composition of yeast RNA-processing complexes. Mol. Cell, 13, 225-239.
27. Du,Y.C. and Stillman,B. (2002) Yph1p, an ORC-interacting protein: potential links between cell proliferation control, DNA replication, and ribosome biogenesis. Cell, 109, 835-848.
28. Deng,C.X. (2006) BRCA1: Cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution. Nucleic Acids Res., 34, 1416-1426.
29. Glover,J.N., Williams,R.S. and Lee,M.S. (2004) Interactions between BRCT repeats and phosphoproteins: Tangled up in two. Trends Biochem. Sci., 29, 579-585.
30. Williams,R.S., Lee,M.S., Hau,D.D. and Glover,J.N. (2004) Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1. Nature Struct. Mol. Biol., 11, 519-525.
31. Bornkamm,G.W., Berens,C., Kuklik-Roos,C., Bechet,J.M., Laux,G., Bachl,J., Korndoerfer,M., Schlee,M., Holzel,M., Malamoussi,A. et al. (2005) Stringent doxycycline-dependent control of gene activities using an episomal one-vector system. Nucleic Acids Res., 33, e137.
32. Bertwistle,D., Sugimoto,M. and Sherr,C.J. (2004) Physical and functional interactions of the Arf tumor suppressor protein with nucleophosmin/B23. Mol. Cell. Biol., 24, 985-996.
33. Burks,D.J., Wang,J., Towery,H., Ishibashi,O., Lowe,D., Riedel,H. and White,M.F. (1998) IRS pleckstrin homology domains bind to acidic motifs in proteins. J. Biol. Chem., 273, 31061-31067.
34. Sikorski,E.M., Uo,T., Morrison,R.S. and Agarwal,A. (2006) Pescadillo interacts with the cadmium response element of the human heme oxygenase-1 promoter in renal epithelial cells. J. Biol. Chem., 281, 24423-24430.
35. Tsai,R.Y. and McKay,R.D. (2005) A multistep, GTP-driven mechanism controlling the dynamic cycling of nucleostemin. J. Cell. Biol., 168, 179-184.
36. Taylor,R.M., Wickstead,B., Cronin,S. and Caldecott,K.W. (1998) Role of a BRCT domain in the interaction of DNA ligase III-alpha with the DNA repair protein XRCC1. Curr. Biol., 8, 877-880.
37. Joo,W.S., Jeffrey,P.D., Cantor,S.B., Finnin,M.S., Livingston,D.M. and Pavletich,N.P. (2002) Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure. Genes Dev., 16, 583-593.
38. Williams,R.S., Green,R. and Glover,J.N. (2001) Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1. Nature Struct. Biol., 8, 838-842.
39. Williams,R.S., Chasman,D.I., Hau,D.D., Hui,B., Lau,A.Y. and Glover,J.N. (2003) Detection of protein folding defects caused by BRCA1-BRCT truncation and missense mutations. J. Biol. Chem., 278, 53007-53016.