Mechanism of radiation induced premature senescence of bone marrow stromal cells: Experiment with murine bone marrow stromal cells

National Medical Journal of China

Volumn 86, Issue 48, 2006, Pages 3431-3434

  Zhang, Ke Jie ^a   Zhu, Yan ^a   Sun, Han Ying ^a   Huang, Li Fang ^a   Fu, Jin Rong ^a   Liu, Wen Li ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Bone marrow cells; Cell aging; Radiation dosage; Radiation injuries

Indexed keywords

BETA GALACTOSIDASE; BIOLOGICAL MARKER; CYCLIN DEPENDENT KINASE INHIBITOR 1; MESSENGER RNA; PROTEIN P53;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; BONE MARROW CULTURE; CELL AGING; CELL CYCLE; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; CYTOCHEMISTRY; FLOW CYTOMETRY; GAMMA RADIATION; GENE EXPRESSION; GIEMSA STAIN; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RADIATION DOSE; RADIATION EXPOSURE; RADIATION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STROMA CELL;

ANIMALS; BONE MARROW CELLS; CELL AGING; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOSE-RESPONSE RELATIONSHIP, RADIATION; FLOW CYTOMETRY; GAMMA RAYS; GENE EXPRESSION; MALE; MICE; MICE, INBRED BALB C; RADIATION INJURIES, EXPERIMENTAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEIN P53;

EID: 33847350918     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Meek DW. The p53 response to DNA damage. DNA Repair(Amst) 2004,3:1049-1056.
2. Dexter TM, Moore MA, Sheridan AP. Maintenance of hemopoietic stem cells production of differentiated progeny in allogeneic and semiallogeneic bone marrow chimeras in vitro. J Exp Med, 1977,145: 1612-1616.
3. Dimri GP, Lee X, Basile G, et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci,1995,92:9363-9367.
4. Wang Y, Schulte BA, Larue AC, et al. Total body irradiation selectively induces murine hematopoietic stern cell senescence. Blood, 2006,107:358-366.
5. Li CH, Tzeng SL, Cheng YW, et al. Chloramphenicol-induced mitochondrial stress increases p2l expression and prevents cell apoptosis through a p21-dependent pathway. J Biol Chem, 2005, 280:26193-26199.
6. Lombard DB, Chua KF, Mostoslavsky R, et al. DNA repair, genome stability, and aging. Cell, 2005,120:497-512.
7. Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell, 2005,120:513-522.
8. Chinese source.