Coexpression of Arp2 and WAVE2 predicts poor outcome in invasive breast carcinoma

Modern Pathology

Volumn 20, Issue 3, 2007, Pages 339-343

  Iwaya, Keiichi ^a   Norio, Kohno ^a   Mukai, Kiyoshi ^a  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Actin; Breast cancer; Histologic grade; Invasion; Polymerization

Indexed keywords

ACTIN RELATED PROTEIN 2; TAMOXIFEN; TEGAFUR; UNCLASSIFIED DRUG; URACIL; WISKOTT ALDRICH SYNDROME PROTEIN; WISKOTT ALDRICH SYNDROME PROTEIN VERPROLINE HOMOLOGOUS PROTEIN 2;

ANAMNESIS; ARTICLE; BREAST CARCINOMA; CANCER CELL; CANCER SURVIVAL; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRADUCTAL CARCINOMA; INVASIVE CARCINOMA; KAPLAN MEIER METHOD; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SURVIVAL RATE; SURVIVAL TIME;

ACTIN-RELATED PROTEIN 2; BREAST NEOPLASMS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIERS ESTIMATE; LYMPHATIC METASTASIS; PROGNOSIS; WISKOTT-ALDRICH SYNDROME PROTEIN FAMILY;

EID: 33847348959     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.3800741     Document Type: Article

References (18)

1. Lauffenburger DA, Horwitz AF. Cell migration: a physically integrated molecular process. Cell 1996;84:359-369.
2. Amann KJ, Pollard TD. Direct real-time observation of actin filament branching mediated by Arp2/3 complex using total internal reflection fluorescence microscopy. Proc Natl Acad Sci USA 2001;98:15009-15013.
3. Fujiwara I, Suetsugu S, Uemura S, et al. Visualization and force measurement of branching by Arp2/3 complex and N-WASP in actin filament. Biochem Biophysics Res Commun 2002;293:1550-1555.
4. Welch MD, Iwamatsu A, Mitchison TJ. Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes. Nature 1997;385:265-269.
5. Schafer DA, Welch MD, Machesky LM, et al. Visualization and molecular analysis of actin assembly in living cells. J Cell Biol 1998;143:1919-1930.
6. Lu Clainche C, Pantaloni D, Carlier MF. ATP hydrolysis on actin-related protein 2/3 complex causes debranching of dendritic actin arrays. Proc Natl Acad Sci USA 2003;100:6337-6342.
7. Suetsugu S, Yamazaki D, Kurisu S, et al. Differential roles of WAVE1 and WAVE2 in dorsal and peripheral ruffle formation for fibroblast cell migration. Dev Cell 2003;5:595-609.
8. Yamazaki D, Suetsugu S, Miki H, et al. WAVE2 is required for directed cell migration and cardiovascular development. Nature 2003;424:452-456.
9. Bailly M, Macaluso F, Cammer M, et al. Relationship between Arp2/3 complex and the barbed ends of actin filaments at the leading edge of carcinoma cells after epidermal growth factor stimulation. J Cell Biol 1999;145:331-345.
10. Oikawa T, Yamaguchi H, Itoh T, et al. PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia. Nat Cell Biol 2004;6:420-426.
11. Kunda P, Craig G, Dominguez V, et al. Abi1, Sra1, and Kette control the stability and localization of SCAR/WAVE to regulate the formation of actin-based protrusions. Curr Biol 2003;13:1867-1875.
12. Semba S, Iwaya K, Matsubayashi J, et al. Coexpression of actin-related protein 2 and Wiskott-Aldrich syndrome family verproline- homologous protein 2 in adenocarcinoma of the lung. Clin Cancer Res. 2006;12:2449-2454.
13. Elston CW, Ellis IO. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 1991;19:403-410.
14. Yamazaki D, Fujiwara T, Suetsugu S, et al. A novel function of WAVE in lamellipodia: WAVE1 is required for stabilization of lamellipodial protrusions during cell spreading. Genes Cells 2005;10:381-392.
15. Sahai E, Marshall CJ. Differing models of tumor cell invasion have distinct requirements for Rho/ROCK signaling and extracellular proteolysis. Nat Cell Biol 2003;5:711-719.
16. Hotulainen P, Lappalainen P. Stress fibers are generated by two distinct actin assembly mechanisms in motile cells. J Cell Biol 2006;173:383-394.
17. Yoshioka K, Foletta V, Bernard O, et al. A role for LIM kinase in cancer invasion. Proc Natl Acad Sci USA 2003;100:7247-7252.
18. Rothschild BL, Shim AH, Ammer AG, et al. Cortactin overexpression regulates actin-related protein 2/3 complex activity, motility, and invasion in carcinoma with chromosome 11q13 amplification. Cancer Res 2006;66:8017-8025.