An analysis of primary site control and late effects according to local control modality in non-metastatic Ewing sarcoma

Pediatric Blood and Cancer

Volumn 48, Issue 4, 2007, Pages 423-429

  Paulino, Arnold C ^a   Nguyen, Thanh X ^b   Mai, Wei Y ^a  

^a HOUSTON METHODIST HOSPITAL   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Ewing sarcoma; Late effects; Local control; Radiotherapy; Surgery

Indexed keywords

CYCLOPHOSPHAMIDE; DACTINOMYCIN; DOXORUBICIN; ETOPOSIDE; IFOSFAMIDE; VINCRISTINE;

ADOLESCENT; ADULT; AGED; AMPUTATION; ARTICLE; CANCER CHEMOTHERAPY; CANCER CONTROL; CANCER LOCALIZATION; CANCER RISK; CANCER SURVIVAL; CHILD; EWING SARCOMA; FEMALE; HUMAN; LEG LENGTH INEQUALITY; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; MUSCLE ATROPHY; OSTEOSARCOMA; PRIORITY JOURNAL; PROGNOSIS; RELAPSE; RISK FACTOR; SCOLIOSIS; SECOND CANCER; SURVIVAL RATE; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AMPUTATION; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BONE NEOPLASMS; CHEMOTHERAPY, ADJUVANT; CHILD; CHILD, PRESCHOOL; COMBINED MODALITY THERAPY; FEMALE; HUMANS; KAPLAN-MEIERS ESTIMATE; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASMS, RADIATION-INDUCED; NEOPLASMS, SECOND PRIMARY; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RADIOTHERAPY, ADJUVANT; SARCOMA, EWING'S; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 33847345999     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.20754     Document Type: Article

References (23)

1. Donaldson SS. Ewing sarcoma: Radiation dose and target volume. Pediatr Blood Cancer 2004;42:471-476.
2. Rosen G, Caparros B, Nirenberg A, et al. Ewing's sarcoma: Ten-year experience with adjuvant chemotherapy. Cancer 1981;47: 2204-2213.
3. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-481.
4. Horowitz ME, Neff JR, Kun LE. Ewing's sarcoma: Radiotherapy versus surgery for local control. Pediatr Clin North Am 1991; 38:365-380.
5. Schuck A, Ahrens S, Paulussen M, et al. Local therapy in localized Ewing tumors: Results of 1058 patients treated in the CESS 81, CESS 86 and EICESS 92 trials. Int J Radiat Oncol Biol Phys 2003;55:168-177.
6. Bacci G, Toni A, Avella M, et al. Long-term results in 144 localized Ewing's sarcoma patients treated with combined therapy. Cancer 1989;63:1477-1486.
7. Mameghan H, Fisher RJ, O'Gorman-Hughes D, et al. Ewing's sarcoma: Long-term follow-up in 49 patients treated from 1967 to 1989. Int J Radiat Oncol Biol Phys 1993;25:431-438.
8. Kuttesch JF, Wexler LH, Marcus RB, et al. Second malignancies after Ewing's sarcoma. J Clin Oncol 1996;14:2818-2825.
9. Dunst J, Schuck A. Role of radiotherapy in Ewing tumors. Pediatr Blood Cancer 2004;42:465-470.
10. Scully SP, Temple HT, O'Keefe RJ, et al. Role of surgical resection in pelvic Ewing's sarcoma. J Clin Oncol 1995;13:2336-2341.
11. Dunst J, Jurgens H, Sauer R, et al. Radiation therapy in Ewing's sarcoma: An update of the CESS 86 trial. Int J Radiat Oncol Biol Phys 1995;32:919-930.
12. Bolek TW, Marcus RB, Jr, Mendenhall NP, et al. Local control and functional results after twice-daily radiotherapy for Ewing's sarcoma of the extremities. Int J Radiat Oncol Biol Phys 1996; 35:687-692.
13. Krasin MJ, Rodriguez-Galindo C, Billups CA, et al. Definitive irradiation in multidisciplinary management of localized Ewing sarcoma family of tumors in pediatric patients: Outcome and prognostic factors. Int J Radiat Oncol Biol Phys 2004;60:830-838.
14. Nesbit ME, Jr, Gehan EA, Burgert EO, Jr, et al. Multimodal therapy for the management of primary nonmetastatic Ewing's sarcoma of bone: A long-term follow-up of the First Intergroup Study. J Clin Oncol 1990;8:1664-1674.
15. Kinsella TJ, Miser JS, Waller B, et al. Long-term follow-up of Ewing's sarcoma of bone treated with combined modality therapy. Int J Radiat Oncol Biol Phys 1991;20:389-395.
16. Donaldson SS, Torrey M, Link MP, et al. A multidisciplinary study investigating radiotherapy in Ewing's sarcoma: End results of POG #8346. Int J Radiat Oncol Biol Phys 1998;42:125-135.
17. Grier HE, Krailo MD, Tarbell NJ, et al. Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med 2003;348: 694-701.
18. Jentzch K, Binder H, Cramer H, et al. Leg function after radiotherapy for Ewing's sarcoma. Cancer 1981;47:1267-1278.
19. Paulino AC. Late effects of radiotherapy for pediatric extremity sarcomas. Int J Radiat Oncol Biol Phys 2004;60:265-274.
20. Hudson MM, Tyc VL, Cremer LK, et al. Patient satisfaction after limb-sparing surgery and amputation for pediatric malignant bone tumors. J Pediatr Oncol Nurs 1998;15:60-69.
21. Zahlten-Hinguranage A, Bernd L, Ewerbeck V, et al. Equal quality of life after limb-sparing or ablative surgery for lower extremity sarcomas. Br J Cancer 2004;91:1012-1014.
22. Weddington WW, Jr, Segraves KB, Simon MA. Psychological outcome of extremity sarcoma survivors undergoing amputation or limb salvage. J Clin Oncol 1985;3:1393-1399.
23. Nagarajan R, Neglia JP, Clohisy DR, et al. Education, employment, insurance and marital status among 694 survivors of pediatric lower extremity bone tumors: A report from the Childhood Cancer Survivor Study. Cancer 2003;97:2554-2564.