A multidisciplinary study investigating radiotherapy in Ewing's sarcoma: End results of POG 8346

International Journal of Radiation Oncology Biology Physics

Volumn 42, Issue 1, 1998, Pages 125-135

  Donaldson, Sarah S ^a,h   Torrey, Margaret ^a   Link, Michael P ^a   Glicksman, Arvin ^b   Gilula, Louis ^c   Laurie, Fran ^b   Manning, John ^d   Neff, James ^e   Reinus, William ^c   Thompson, Elizabeth ^f   Shuster, Jonathan J ^g  

^a STANFORD UNIVERSITY   (United States)

^b Quality Assurance Review Center   (United States)

^c WASHINGTON UNIVERSITY   (United States)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^e UNIVERSITY OF KANSAS   (United States)

^f ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^g UNIVERSITY OF FLORIDA   (United States)

^h c/o Pediatric Oncology Group ^*  (United States)

Author keywords

Ewing's sarcoma; Multidisciplinary therapy; POG; Radiotherapy; Surgery

Indexed keywords

CYCLOPHOSPHAMIDE; DACTINOMYCIN; DOXORUBICIN; VINCRISTINE;

ADOLESCENT; ADULT; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER CONTROL; CANCER RADIOTHERAPY; CANCER SURGERY; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EWING SARCOMA; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; METASTASIS; MULTICENTER STUDY; NUCLEAR MAGNETIC RESONANCE IMAGING; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RADIATION DOSE; RADIATION FIELD; RANDOMIZED CONTROLLED TRIAL; SURVIVAL RATE; TREATMENT FAILURE; TREATMENT OUTCOME; TUMOR VOLUME;

EID: 0031695513     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(98)00191-6     Document Type: Article

References (35)

1. Burgert EJ, Nesbit ME, Garnsey LA, Gehan EA, Herrmann J, Vietti TJ, Cangir A, Tefft M, Evans R, Thomas P, et al. Multimodal therapy for the management of nonpelvic, localized Ewing's sarcoma of bone: Intergroup study IESS-II. J Clin Oncol 1990;8:1514-1524.
2. Dunst J, Jurgens H, Sauer R, Pape H, Paulussen M, Winkelmann W, Rube C. Radiation therapy in Ewing's sarcoma: An update of the CESS 86 trial. Int J Radiat Oncol Biol Phys 1995;32:919-930.
3. Evans RG, Nesbit ME, Gehan EA, Garnsey LA, Burgert OJ, Vietti TJ, Cangir A, Tefft M, Thomas P, Askin FB, et al. Multimodal therapy for the management of localized Ewing's sarcoma of pelvic and sacral bones: A report from the second intergroup study. J Clin Oncol 1991;9:1173-1180.
4. Jurgens H, Exner U, Gadner H, Harms D, Michaelis J, Sauer R, Treuner J, Voute T, Winkelmann W, Winkler K, et al. Multidisciplinary treatment of primary Ewing's sarcoma of bone. A 6-year experience of a European Cooperative Trial. Cancer 1988;61:23-32.
5. Nesbit MJ, Gehan EA, Burgert EJ, Vietti TJ, Cangir A, Tefft M, Evans R, Thomas P, Askin FB, Kissane JM, et al. Multimodal therapy for the management of primary, nonmetastatic Ewing's sarcoma of bone: A long-term follow-up of the First Intergroup study. J Clin Oncol 1990;8:1664-1674.
6. Hayes FA, Thompson EI, Hustu HO, Kumar M, Coburn T, Webber B. The response of Ewing's sarcoma to sequential cyclophosphamide and adriamycin induction therapy. J Clin Oncol 1983;1:45-51.
7. Enneking WF, Spanier SS, Goodman MA. A system for the surgical staging of musculoskeletal sarcoma. Clin Orthop 1980;106-120.
8. Kaplan EL, Meier P. Non-parametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-481.
9. Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, Mantel N, McPherson K, Peto J, Smith PG. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples. Br J Cancer 1977;35:1-39.
10. Lehman EL. Non-parametrics: Statistical method based on ranks. San Francisco: Holden-Day; 1975.
11. Reinus WR, Gilula LA, Donaldson SS, Shuster J, Vietti T. Prognostic features of Ewing's sarcoma on radionuclide bone scan after inital treatment. Eur J Radiol 1994;19:1-6.
12. Reinus WR, Gilula LA, Donaldson S, Shuster J, Glicksman A, Vietti T. Prognostic features of Ewing sarcoma on plain radiograph and computed tomography scan after initial treatment. Cancer 1993;72:2503-2510.
13. Sailor SL, Harmon DC, Mankin HJ, Truman JT, Suit HD. Ewing's sarcoma: Surgical resection as a prognostic factor. Int J Radiat Oncol Biol Phys 1989;15:43-52.
14. Wilkins RM, Pritchard DJ, Burgert EJ, Unni KK. Ewing's sarcoma of bone. Experience with 140 patients. Cancer 1986; 58:2551-2555.
15. Scully SP, Temple HT, O'Keefe RJ, Scarborough MT, Mankin HJ, Gebhardt MC. Role of surgical resection in pelvic Ewing's sarcoma. J Clin Oncol 1995;13:2336-2341.
16. Tucker MA, D'Angio GJ, Boice JD, Strong LC, Li FP, Stovall M, Stone BJ, Green DM, Lombardi F, Newton W, Hoover RN, Frumeni JF. Bone sarcomas linked to radiotherapy in children. N Engl J Med 1987;317:588-593.
17. Strong LC, Herson J, Osborne BM, Sutow WW. Risk of radiation-related subsequent malignant tumors in survivors of Ewing's sarcoma. J Natl Cancer Inst 1979;62:1401-1406.
18. Greene MH, Glaubiger DL, Mead GD, Fraumeni JF. Subsequent cancer in patients with Ewing's sarcoma. Cancer Treat Rep 1979;63:2043-2046.
19. Smith LM, Cox RS, Donaldson SS. Second cancers in long-term survivors of Ewing's sarcoma. Clin Orthop 1992;274: 275-281.
20. Perez CA, Tefft M, Nesbit MJ, Burgert EJ, Vietti TJ, Kissane J, Pritchard DJ, Gehan EA. Radiation therapy in the multimodal management of Ewing's sarcoma of bone: Report of the Intergroup Ewing's Sarcoma Study. Natl Cancer Inst Monogr 1981;263-271.
21. Marcus RJ, Cantor A, Heare TC, Graham PJ, Mendenhall NP, Million RR. Local control and function after twice-a-day radiotherapy for Ewing's sarcoma of bone. Int J Radiat Oncol Biol Phys 1991;21:1509-1515.
22. Brown JM, Giaccia AJ. Tumour hypoxia: The picture has changed in the 1990s. Int J Radiat Biol 1994;65:95-102.
23. Murphy WA. Imaging bone tumors in the 1990's. Cancer 1991;67:1169-1176.
24. Cangir A, Vietti TJ, Gehan EA, Burgert EJ, Thomas P, Tefft M, Nesbit ME, Kissane J, Pritchard D. Ewing's sarcoma metastatic at diagnosis. Results and comparisons of two intergroup Ewing's sarcoma studies. Cancer 1990;66:887-893.
25. Gasparini M, Lombardi F, Ballerini E, Gandola L, Gianni MC, Massimino M, Rottoli L, Fossati BF. Long-term outcome of patients with monostotic Ewing's sarcoma treated with combined modality. Med Pediatr Oncol 1994;23:406-412.
26. Arai Y, Kun LE, Brooks MT, Fairclough DL, Fontanesi J, Meyer WH, Hayes FA, Thompson E, Rao BN. Ewing's sarcoma: Local tumor control and patterns of failure following limited-volume radiation therapy. Int J Radiat Oncol Biol Phys 1991;21:1501-1508.
27. Oberlin O, Patte C, Demeocq F, Lacombe MJ, Brunat MM, Demaille MC, Tron P, N'Guyen BB, Lemerle J. The response to initial chemotherapy as a prognostic factor in localized Ewing's sarcoma. Eur J Cancer Clin Oncol 1985;21:463-467.
28. Sauer R, Jurgens H, Burgers JM, Dunst J, Hawlicek R, Michaelis J. Prognostic factors in the treatment of Ewing's sarcoma. The Ewing's Sarcoma Study Group of the German Society of Paediatric Oncology CESS 81. Radiother Oncol 1987;10:101-110.
29. Smith MA. The impact of doxorubicin dose intensity on survival of patients with Ewing's sarcoma [letter]. J Clin Oncol 1991;9:889-890.
30. Smith MA, Ungerleider RS, Horowitz ME, Simon R. Influence of doxorubicin dose intensity on response and outcome for patients with osteogenic sarcoma and Ewing's sarcoma. J Natl Cancer Inst 1991;83:1460-1470.
31. Miser JS, Kinsella TJ, Triche TJ, Tsokos M, Forquer R, Wesley R, Horvath K, Belasco J, Longo DL, Steis R, et al. Preliminary results of treatment of Ewing's sarcoma of bone in children and young adults: Six months of intensive combined modality therapy without maintenance. J Clin Oncol 1988;6:484-490.
32. Grier H, Krailo M, Link M, Tarbell N, Fryer C, Pritchard D, Gebhardt M, Dickman P, Pearlman E, Meyer P, Moore S, Raussen P, Vietti T, Miser J. Improved outcome in nonmetastatic Ewing's sarcoma (EWS) and PNET of bone with the addition of ifosfamide (I) and etoposide (E) to vincristine (V), adriamycin (Ad), cylophosphamide (C), and actinomycin (A): A Children's Cancer Group (CCG) and Pediatric Oncology Group (POG) report. Am Soc Clin Oncol Proc 1994;13: 421.
33. Grier H, Krailo M, Tarbell N, Link M, Fryer C, Pritchard D, Gebhardt M, Dickman P, Pearlman E, Meyers P, Moore S, Donaldson S, Rausen A, Vietti T, Miser J. Adding ifosfamide (I) and etoposide (E) to vincristine (V), cyclophosphamide (C), adriamycin (Ad), and actinomycin (A) improves outcome in non-metastatic Ewing's (EWS) and PNET: Update of COG/ POG study. Med Pediatr Oncol 1996;27:259
34. Meyer WH, Kun L, Marina N, Robertson P, Parham D, Rao B, Fletcher B, Pratt CB. Ifosfamide plus etoposide in newly diagnosed Ewing's sarcoma of bone. J Clin Oncol 1992;10: 1737-1742.
35. Gobel V, Jurgens H, Etspuler G, Kemperdick H, Jungblut RM, Stiene U, Gobel U. Prognostic significance of tumor volume in localized Ewing's sarcoma of bone in children and adolescents. J Cancer Res Clin Oncol 1987;113:187-191.