Contribution of the fermenting yeast strain to ethyl carbamate generation in stone fruit spirits

Applied Microbiology and Biotechnology

Volumn 74, Issue 4, 2007, Pages 843-850

  Schehl, Beatus ^a   Senn, Thomas ^a   Lachenmeier, Dirk W ^b   Rodicio, Rosaura ^c   Heinisch, Jürgen J ^a,d  

^a UNIVERSITY OF HOHENHEIM   (Germany)

^b Chemisches und Veterinäruntersuchungsamt ^*  (Germany)

^c Instituto de Biotecnologia de Asturias   (Spain)

^d UNIVERSITY OF OSNABRÜCK   (Germany)

Author keywords

Ethyl carbamate; Fermentation; Saccharomyces; Spirit; Yeast

Indexed keywords

ARGINASE ACTIVITIES; CHERRY MASHES; ETHYL CARBAMATES;

CARCINOGENS; ETHANOL; FERMENTATION; FRUITS; UREA;

YEAST;

ARGINASE; CAR1 PROTEIN; FUNGAL PROTEIN; UNCLASSIFIED DRUG; UREA; URETHAN;

CARBAMATE (ESTER); CARCINOGEN; CATABOLISM; CYANIDE; ETHANOL; FERMENTATION; FRUIT; GENETIC ENGINEERING; LABORATORY METHOD; SUGAR; UREA; YEAST;

ARTICLE; CHERRY; CONTROLLED STUDY; DIPLOIDY; ENZYME ACTIVITY; FERMENTATION; FUNGAL STRAIN; GENE DELETION; GENETIC ENGINEERING; HETEROZYGOSITY; NONHUMAN; SACCHAROMYCES CEREVISIAE; STATISTICAL SIGNIFICANCE; STONE FRUIT; YEAST;

ARGINASE; ETHANOL; FERMENTATION; GENE DELETION; HEXOSES; PRUNUS; SACCHAROMYCES CEREVISIAE; UREA; URETHANE;

CARCINOGENS; ETHANOL; FERMENTATION; FRUITS; UREA; YEASTS;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 33847337411     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-006-0736-4     Document Type: Article

References (30)

1. An D, Ough CS (1993) Urea excretion and uptake by wine yeasts as affected by various factors. Am J Enol Vitic 44:34-40
2. Aresta M, Boscolo M, Franco DW (2001) Copper(II) catalysis in cyanide conversion into ethyl carbamate in spirits and relevant reactions. J Agric Food Chem 49:2819-2824
3. Baumann U, Zimmerli B (1986) Gas chromatographic determination of urethane (ethyl carbamate) in alcoholic beverages. Mitt Geb Lebensmunters Hyg 77:327-332
4. Funch F, Lisbjerg S (1988) Analysis of ethyl carbamate in alcoholic beverages. Zeitschrift für Lebensmittel-Untersuchung und-Forschung 186:29-32
5. Green SM, Eisenstein E, McPhie P, Hensley P (1990) The purification and characterization of arginase from Saccharomyces cerevisiae. J Biol Chem 265:1601-1607
6. Güldener U, Heck S, Fielder T, Beinhauer J, Hegemann JH (1996) A new efficient gene disruption cassette for repeated use in budding yeast. Nucleic Acids Res 13:2519-2524
7. Kitamoto K, Oda K, Gomi K, Takahashi K (1991) Genetic engineering of a sake yeast producing no urea by successive disruption of arginase gene. Appl Environ Microbiol 57:301-306
8. Lachenmeier DW, Frank W, Kuballa T (2004) Application of tandem mass spectrometry combined with gas chromatography to the routine analysis of ethyl carbamate in stone-fruit spirits. Rapid Commun Mass Spectrom 19:108-112
9. Lachenmeier DW, Schehl B, Kuballa T, Frank W, Senn T (2005) Retrospective trends and current status of ethyl carbamate in German stone-fruit spirits. Food Addit Contam 22:397-405
10. Melzoch K, Hajslova J, Sitner V (1996) Ethyl carbamate in distillates: occurrence, formation and risk assessment. Zahradnictvi-UZPI 23:99-104
11. Messenguy F, Vierendeels F, Scherens B, Dubois E (2000) In Saccharomyces cerevisiae, expression of arginine catabolic genes CAR1 and CAR2, in response to exogenous nitrogen availability is mediated by the Ume6 (CargRI)-Sin3 (CargRII)-Rpd3 (CargRIII) complex. J Bacteriol 182:3158-3164
12. Mildau G, Preuß A, Frank W, Heering W (1987) Ethyl carbamate (urethane) in alcoholic beverages: improved analysis and light-dependent formation. Dtsch Lebensm-Rundsch 83:69-74
13. Monteiro FF, Trouosdale E, Bisson LF (1989) Ethyl carbamate formation in wine: use of radioactively labeled precursors to demonstrate the involvement of urea. Am J Enol Vitic 40:1-8
14. Ough CS (1976) Ethyl carbamate in fermented beverages and foods: I. Naturally occurring ethyl carbamate. J Agric Food Chem 24:323-328
15. Ough CS, Trioli G (1988) Urea removal from wine by an acid urease. Am J Enol Vitic 39:303-307
16. Ough CS, Crowell EA, Gutlove BR (1988) Carbamyl compound reactions with ethanol. Am J Enol Vitic 39:239-249
17. Ough CS, Stevens D, Sendovski T, Huang Z, An D (1990) Factors contributing to urea formation in commercially fermented wines. Am J Enol Vitic 41:68-73
18. Pieper HJ, Rau T, Eller T, Volz A (1987) Schnellmethode zur Bestimmung des Acetaldehyds unter besonderer Berücksichtigung der Qualitä tskontrolle bei der Produktion von Obstbranntwein. Dtsch Lebensm-Rundsch 83:35-41
19. Pretorius IS (2000) Tailoring wine yeast for the new millenium: novel approaches to the ancient art of winemaking. Yeast 16:675-729
20. Robzyk K, Kassir Y (1992) A simple and highly efficient procedure for rescuing autonomous plasmids from yeast. Nucleic Acids Res 20:3790
21. Schehl B, Müller C, Senn T, Heinisch JJ (2004) A laboratory yeast strain suitable for spirit production. Yeast 21:1375-1389
22. Schehl B, Lachenmeier D, Senn T, Heinisch JJ (2005) Effect of the stone content on the quality of plum and cherry spirits produced from mash fermentations with commercial and laboratory yeast strains. J Agric Food Chem 53:8230-8238
23. Shima J, Sakata-Tsuda Y, Suzuki Y, Nakajima R, Watanabe H, Kawamoto S, Takano H (2003) Disruption of the CAR1 gene encoding arginase enhances freeze-tolerance of the commercial Baker's yeast Saccharomyces cerevisiae. Appl Environ Microbiol 69:715-718
24. Sumrada RA, Cooper TG (1984) Nucleotide sequence of the Saccharomyces cerevisiae arginase gene (CAR1) and its transcription under various physiological conditions. J Bacteriol 160:1078-1087
25. Walker GM (1998) Yeast - physiology and biotechnology. Wiley, West Sussex, England
26. Whitney PA, Magasanik B (1973) The induction of arginase in Saccharomyces cerevisiae. J Biol Chem 17:6197-6202
27. Wurzinger A, Bandion F (1985) Quantitative determination of total hydrocyanic acid in fruit distillates and fruit brandies. Mitt Klosterneuburg 35:42-44
28. Wurzinger A, Bandion F (1993) Detection and assessment of hydrocyanic acid in wine. Mitt Klosterneuburg 43:180-184
29. Yoshizawa K, Takahashi K (1988) Utilization of urease for urea decomposition in Sake. J Brew Soc Jpn 83:142-144
30. Zamenhoff S (1957) Preparation and assay of deoxyribonucleic acids from animal tissue. Methods Enzymol 3:702-704