A method to determine precise benchmark doses for carbamate anticholinesterases

Toxicological Sciences

Volumn 96, Issue 1, 2007, Pages 154-161

  Lassiter, T Leon ^a   Brimijoin, Stephen ^a  

^a MAYO GRADUATE SCHOOL   (United States)

Author keywords

Benchmark dose; Brain; Carbamate; Cholinesterase; Rat; Reactivation

Indexed keywords

CARBAMIC ACID DERIVATIVE; CHOLINESTERASE; DYFLOS; FORMETANATE; METHOMYL; OXAMYL;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL MODIFICATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INACTIVATION; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PREDICTION; QUALITY CONTROL; RAT; TOXICOKINETICS; TOXIN ANALYSIS;

ANIMALS; BIOLOGICAL ASSAY; BRAIN; CARBAMATES; CENTRIFUGATION; CHOLINESTERASE INHIBITORS; CHOLINESTERASES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; ISOFLUROPHATE; KINETICS; MALE; METHOMYL; MICE; MICE, INBRED C57BL; MODELS, CHEMICAL; PESTICIDES; RATS; RATS, LONG-EVANS; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; TIME FACTORS;

RATTUS;

EID: 33847332668     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfl183     Document Type: Article

References (24)

1. Bignami, G., Rosíc, N., Michalek, H., Milosevíc, M., and Gatti, G. L. (1975). Behavioral toxicity of anticholinesterase agents: Methodological, neurochemical, and neuropsychological aspects. In Behavioral Toxicology (B. Weiss and V. G. Laties, Eds.), pp. 155-216. Plenum Press, New York.
2. Bowman, W. C., and Rand, M. J. (1980). Absorption, distribution, excretion and metabolism of drugs: Biopharmaceutics and pharmacokinetics. In Textbook of Pharmacology, 2nd ed. (W. C. Bowman and M. J. Rand, Eds.), Chap. 40, pp. 50-51. Blackwell Scientific Publications, Oxford.
3. Dawson, R. M., and Poretski, M. (1977). Phenyldichlorophosphate as an aid in studies of decarbamylation of carbamylated acetylcholinesterase. Anal. Biochem. 179, 451-455.
4. Ecobichon, D. J. (2001). Toxic effects of pesticides. In Casarett & Doull's Toxicology, The Basic Science of Poisons (C. D. Klaassen, Ed.), pp. 763-810. McGraw-Hill, New York.
5. Ellman, G. L., Courtney, K. D., Andres, V., Jr, and Featherstone, R. M. (1961). A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7, 88-95.
6. French, M. C., Sellers, D. J., and Wilkinson, R. G. (1977). A comparison of methods for measuring acetyl cholinesterase activity in blood samples inhibited by carbamates. Biochem. Pharmacol. 26, 1263-1266.
7. Gupta, R. C., Patterson, G. T., and Dettbarn, W. D. (1986). Mechanisms of toxicity and tolerance to diisopropylphosphorofluoridate at the neuromuscular junction of the rat. Toxicol. Appl. Pharmacol. 84, 541-550.
8. Hunt, K. A., and Hooper, M. J. (1993). Development and optimization of reactivation techniques for carbamate-inhibited brain and plasma cholinesterases in birds and mammals. Anal. Biochem. 212, 335-343.
9. Hunt, K. A., Hooper, M. J., and Littrell, E. E. (1995). Carbofuran poisoning in herons: Diagnosis using cholinesterase reactivation techniques. J. Wildl. Dis. 31, 186-192.
10. Hunter, D. L., and Padilla, S. (1999). Influence of storage conditions on the stability of cholinesterase activity in plasma and brain tissue taken from carbamate or organophosphorus pesticide-treated rats. Toxicol. Methods 9, 189-199.
11. International Life Sciences Institute (ILSI) (1999). Common Mechanism of Toxicity: Evaluation of Carbamate Pesticides. International Life Sciences Institute, Washington, DC.
12. Johnson, C. D., and Russell, R. L. (1975). A rapid simple radiometric assay for cholinesterase, suitable for multiple determinations. Anal. Biochem. 64, 229-238.
13. Kirman, C. R., Sweeney, L. M., Meek, M. E., and Gargas, M. L. (2003). Assessing the dose-dependency of allometric scaling performance using physiologically based pharmacokinetic modeling. Regul. Toxicol. Pharmacol. 38, 345-367.
14. Li, B., Stribley, J. A., Ticu, A., Xie, W., Schopfer, L. M., Hammond, P., Brimijoin, S., Hinrichs, S., and Lockridge, O. (2000). Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse. J. Neurochem. 75, 1320-1331.
15. Moser, V. C. (1999). Comparison of aldicarb and methamidophos neurotoxicity at different ages in the rat: Behavioral and biochemical parameters. Toxicol. Appl. Pharmacol. 157, 94-106.
16. Nostrandt, A. C., Duncan, J. A., and Padilla, S. (1993). A modified spectrophotometric method appropriate for measuring cholinesterase activity in tissue from carbaryl-treated animals. Fundam. Appl. Toxicol. 21, 196-203.
17. Reiner, E. (1971). Spontaneous reactivation of phosphorylated and carbamylated cholinesterase. Bull. W H O. 44, 109-112.
18. Reiner, E., and Aldridge, W. N. (1967). Effect of pH on inhibition and spontaneous reactivation of acetylcholinesterase treated with esters of phosphorus acids and of carbamic acids. Biochem. J. 106, 171-179.
19. Roufogalis, B. D., and Thomas, J. (1969). The effect of organic and inorganic cations on the decarbamylation of dimethylcarbamyacetylcholinesterase: A comparison with deacetylation. Mol. Pharmacol. 5, 286-293.
20. Sand, S., von Rosen, D., Victorin, K., and Filipsson, A. F. (2006). Identification of a critical dose level for risk assessment: developments in benchmark dose analysis of continuous endpoints. Toxicol. Sci. 90, 241-251.
21. Sheets, L. P., Hamilton, B. F., Sangha, G. K., and Thyssen, J. H. (1997). Subchronic neurotoxicity screening studies with six organophosphate insecticides: An assessment of behavior and morphology relative to cholinesterase inhibition. Fundam. Appl. Toxicol. 35, 101-119.
22. United States Environmental Protection Agency (USEPA) (1992). Draft report: A cross-species scaling factor for carcinogen risk assessment based on equivalence of mg/kg3/4/day. Fed. Regist. 57, 24152-24173.
23. United States Environmental Protection Agency (USEPA) (2004). Carbamate cumulative assessment group; availability. Fed. Regist. 69, 5340-5344.
24. United States Environmental Protection Agency (USEPA) (2005). Preliminary cumulative risk assessment for the N-methyl carbamates. Available at: http://www.epa.gov.