Quantification of isoniazid and acetylisoniazid in rat plasma and alveolar macrophages by liquid chromatography-tandem mass spectrometry with on-line extraction

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 847, Issue 2, 2007, Pages 188-198

  Ng, Ka yun ^a   Zhou, Huiyu ^a   Zhang, Yan Ling ^a   Hybertson, Brooks ^c   Randolph, Theodore ^b   Christians, Uwe ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c University of Colorado at Boulder   (United States)

Author keywords

Acetylated isoniazid; Isoniazid; LC LC MS MS; Microparticles; Pharmacokinetics; PLA; Tuberculosis

Indexed keywords

ANIMAL CELL CULTURE; ANTIBIOTICS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS; PULMONARY DISEASES;

ACETYLATED ISONIAZID; ISONIAZID; MICROPARTICLES; PLA; TUBERCULOSIS;

LIVING SYSTEMS STUDIES;

ACETYLISONIAZID; DRUG METABOLITE; ISONIAZID; METHANIAZIDE;

ANIMAL CELL; ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG METABOLISM; DRUG TARGETING; HOMOGENATE; LIQUID CHROMATOGRAPHY; LUNG ALVEOLUS MACROPHAGE; MICROPARTICLE ENZYME IMMUNOASSAY; NONHUMAN; PRIORITY JOURNAL; RAT; REPRODUCIBILITY; TANDEM MASS SPECTROMETRY; TARGET CELL;

ANIMALS; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ISONIAZID; MACROPHAGES, ALVEOLAR; MALE; MOLECULAR STRUCTURE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 33847295103     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2006.10.008     Document Type: Article

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