msHOT: Modifying Hudson's ms simulator to incorporate crossover and gene conversion hotspots

Bioinformatics

Volumn 23, Issue 4, 2007, Pages 520-521

  Hellenthal, Garrett ^a   Stephens, Matthew ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b University of Chicago   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME ANALYSIS; COMPUTER PROGRAM; COMPUTER SIMULATION; CROSSING OVER; GENE CONVERSION; GENE MUTATION; GENETIC RECOMBINATION; GENETIC VARIABILITY; MATHEMATICAL COMPUTING; POPULATION GENETICS; POPULATION MIGRATION; POPULATION SIZE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 33847273741     PISSN: 13674803     EISSN: 13674811     Source Type: Journal    
DOI: 10.1093/bioinformatics/btl622     Document Type: Article

References (8)

1. Hudson,R. (1983) Properties of a neutral allele model with intragenic recombination. Theor. Popul. Biol., 23, 183-201.
2. Hudson,R. (2002) Generating samples under a Wright-Fisher neutral model of genetic variation. Bioinformatics, 18, 337-338.
3. Jeffreys,A. and May,C. (2004) Intense and highly localized gene conversion activity in human meiotic crossover hot spots. Nat. Genet., 36, 151-156.
4. Jeffreys,A. et al. (2001) Intensely punctate meiotic recombination in the class II region of the major histocompatibility complex. Nat. Genet., 29, 217-222.
5. Myers,S. et al. (2005) A fine-scale map of recombination rates and hotspots across the human genome. Science, 310, 321-324.
6. Schaffner,S. et al. (2005) Calibrating a coalescent simulation of human genome sequence variation. Genome Res., 15, 1576-1583.
7. Szostak,J. et al. (1983) The double-strand-break repair model for recombination. Cell, 33, 25-35.
8. Wiuf,C. and Hein,J. (2000) The coalescent with gene conversion. Genetics, 155, 451-462.