Theory and statistics of detecting synergism between two active drugs: cocaine and buprenorphine

Psychopharmacology

Volumn 133, Issue 4, 1997, Pages 378-382

  Tallarida, Ronald J ^a   Kimmel, Heather L ^b   Holtzman, Stephen G ^b  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Buprenorphine; Cocaine; Drug interactions; Isobologram; Statistics; Synergism

Indexed keywords

BUPRENORPHINE; COCAINE;

ARTICLE; DOSE RESPONSE; DRUG INTERACTION; DRUG TOXICITY; NONHUMAN; PRIORITY JOURNAL; STATISTICS; THEORY;

ANIMALS; BUPRENORPHINE; COCAINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; DRUG SYNERGISM; MALE; MODELS, PSYCHOLOGICAL; NARCOTIC ANTAGONISTS; NARCOTICS; RATS; RATS, SPRAGUE-DAWLEY; RESEARCH DESIGN; ROTATION; STEREOTYPED BEHAVIOR; SUBSTANTIA NIGRA;

EID: 0030732241     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050417     Document Type: Article

References (12)

1. Fieller EC (1944) A fundamental formula in the statistics of biological assay, and some applications. Q J Pharmacol 17: 117-123
2. Finney DJ (1971) Probit analysis, 3rd edn.Cambridge University Press, Cambridge
3. Jiang Q, Sheldon RF, Porreca F (1988) Sites of clonidine action to inhibit gut propulsion in mice: demonstration of a central component. Gastroenterology 95:1265-1271
4. Kimmel HL, Tallarida RJ, Holtzman SG (1997) Synergism between buprenorphine and cocaine on the rotational behavior of the nigrally-lesioned rat. Psychopharmacology 133:372-377
5. Ossipov MH, Lozito R, Messineo E, Green J, Harris S (1990) Spinal antinociceptive synergy between clonidine and morphine, U69593, and DPDPE. Isobolographic analysis. Life Sci 46: PL71-76
6. Roerig SC, Fujimoto JM (1988) Morphine antinociception in different strains of mice: relationship of supraspinal-spinal multiplicative interaction to tolerance. J Pharmacol Exp Ther 247: 603-608
7. Tallarida RJ (1992) Statistical analysis of drug combinations for synergism. Pain 49:93-97
8. Tallarida RJ, Murray RB (1987) Manual of pharmacologic calculation with computer programs, 2nd edn. Springer, New York
9. Tallarida RJ, Porreca F, Cowan A (1989) Statistical analysis of drug-drus and site-site interactions with isobolograms. Life Sci 45:947-961
10. Wessinger WD (1986) Approaches to the study of drug interactions in behavioral pharmacology. Neurosci Biobehav Rev 10: 103-113
11. Woolverton WL (1987) Analysis of drug interactions in behavioral pharmacology. In: Thompson T, Dews PB, Barrett JE (eds) Neurobehavioral pharmacology. Lawrence Erlbaum Associates, Hillsdale, N J, pp 275-302
12. Yeung JC, Rudy J (1980) Multiplicative interaction between narcotic agonisms expressed at spinal and supraspinal sites of antinociceptive action as revealed by concurrent intrathecal and intracerebroventricular injections of morphine. J Pharmacol Exp Ther 215:633-642