Intranasal trigeminal function in subjects with and without an intact sense of smell

Brain Research

Volumn 1139, Issue 1, 2007, Pages 235-244

  Iannilli, E ^a,b   Gerber, J ^c   Frasnelli, J ^a,d   Hummel, T ^a  

^a UNIVERSITY OF DRESDEN MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF CHIETI   (Italy)

^c UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^d MCGILL UNIVERSITY   (Canada)

Author keywords

Anosmia; Irritation; Olfaction; Smell; Trigeminal

Indexed keywords

CARBON DIOXIDE;

ADULT; ANOSMIA; ARTICLE; CEREBELLUM; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FRONTAL LOBE; HUMAN; INSULA; LIMBIC CORTEX; MALE; MOTOR CORTEX; NOSE IRRITATION; NUCLEAR MAGNETIC RESONANCE IMAGING; ODOR; PREFRONTAL CORTEX; PREMOTOR CORTEX; PRIORITY JOURNAL; PUTAMEN; SMELLING; SOMATOSENSORY CORTEX; SUBICULUM; SUPPLEMENTARY MOTOR AREA; TEMPORAL LOBE; TRIGEMINAL NERVE;

ADULT; BRAIN MAPPING; CEREBRAL CORTEX; FEMALE; FUNCTIONAL LATERALITY; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NASAL MUCOSA; OLFACTION DISORDERS; OLFACTORY PATHWAYS; SMELL; STATISTICS, NONPARAMETRIC; TRIGEMINAL NERVE;

EID: 33847271588     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2006.12.082     Document Type: Article

References (50)

1. Abolmaali N.D., Hietschold V., Vogl T.J., Huttenbrink K.B., and Hummel T. MR evaluation in patients with isolated anosmia since birth or early childhood. AJNR Am. J. Neuroradiol. 23 (2002) 157-164
2. Adcock J.E., Wise R.G., Oxbury J.M., Oxbury S.M., and Matthews P.M. Quantitative fMRI assessment of the differences in lateralization of language-related brain activation in patients with temporal lobe epilepsy. Neuroimage 18 (2003) 423-438
3. Apkarian A.V., Bushnell M.C., Treede R.D., and Zubieta J.K. Human brain mechanism of pain perception and regulation in health and disease. Eur. J. Pain 9 (2005) 463-484
4. Ashburner J., Friston K.J., and Penny W.D. Spatial normalization using basis function. In: Frackowiak R.S.J., Frith C., Dolan R., Friston K.J., Price C.J., Zeki S., Ashburner J., and Penny W.D. (Eds). Human Brain Function. 2nd ed. (2003), Academic Press, New York 25-42
5. Cain W.S., and Murphy C. Interaction between chemoreceptive modalities of odour and irritation. Nature 284 (1980) 255-257
6. Cashion E.H., Livermore A., and Hummel T. Odour suppression in binary mixtures. Biol. Psychol. 73 (2006) 288-297
7. Chudler E.H., Dong W.K., and Kawakami Y. Tooth pulp evoked potentials in the monkey: cortical surface and intracortical distribution. Pain 22 (1985) 221-223
8. 2 in bullfrogs. Am. J. Physiol. 258 5 Pt. 2 (1990) R1207-R1212
9. Cometto-Muniz J.E., Cain W.S., and Abraham M.H. Determinants for nasal trigeminal detection of volatile organic compounds. Chem. Senses 30 (2005) 627-642
10. Deblaere K., Boon P.A., Vandemaele P., Tieleman A., Vonck K., Vingerhoets G., Backes W., Defreyne L., and Achten E. MRI language dominance assessment in epilepsy patients at 1.0 T: region of interest analysis and comparison with intracarotid amytal testing. Neuroradiology 46 (2004) 413-420
11. Doty R.L., Brugger W.P.E., Jurs P.C., Orndorff M.A., Snyder P.J., and Lowry L.D. Intranasal trigeminal stimulation from odorous volatiles: psychometric responses from anosmic and normal humans. Physiol. Behav. 20 (1978) 175-185
12. Elsberg C.A., Levy I., and Brewer E.D. The sense of smell. VI. The trigeminal effects of odorous substances. Bull. Neurol. Inst. N.Y. 4 (1935) 270-285
13. Finger T.E., and Böttiger B. Peripheral peptidergic fibers of the trigeminal nerve in the olfactory bulb of the rat. J. Comp. Neurol. 334 (1993) 117-124
14. Frasnelli J., Schuster B., Zahnert T., and Hummel T. Chemosensory specific reduction of trigeminal sensitivity in subjects with olfactory dysfunction. Neuroscience 142 (2006) 541-546
15. Frasnelli J., Schuster B., and Hummel T. Subjects with congenital anosmia have larger peripheral but similar central trigeminal responses. Cereb. Cortex 17 (2007) 370-377
16. Fröhlich R. Ueber einige Modificationen des Geruchsinnes. Akad. Wiss. Wien, Math.-Nat. CL. 6 (1851) 322-328
17. Gaillard W.D., Balsamo L., Xu B., Grandin C.B., Braniecki S.H., Papero P.H., Weinstein S., Conry J., Pearl P.L., Sachs B., Sato S., Jabbari B., Vezina L.G., Frattali C., and Theodore W.H. Language dominance in partial epilepsy patients identified with an fMRI reading task. Neurology 59 (2002) 256-265
18. Gottfried J.A. Smell: central nervous processing. Adv. Oto-rhino-laryngol. 63 (2006) 44-69
19. Gudziol H., Schubert M., and Hummel T. Decreased trigeminal sensitivity in anosmia. ORL J. Oto-rhino-laryngol. Relat. Spec. 63 (2001) 72-75
20. Handwerker H., and Kobal G. Psychophysiology of experimentally induced pain. Physiol. Rev. 73 (1993) 639-671
21. Hari R., and Forss N. Magnetoencephalography in the study of human somatosensory cortical processing. Philos. Trans. R. Soc. Lond., B Biol. Sci. 354 (1999) 1145-1154
22. 2 stimulation of the human nasal mucosa. Pain 72 (1997) 145-151
23. Holland S.K., Plante E., Byars A., Strawsburg R.H., Schmithorst V.J., and Ball Jr. W.S. Normal fMRI brain activation patterns in children performing a verb generation task. Neuroimage 14 (2001) 837-843
24. Hummel T., and Livermore A. Intranasal chemosensory function of the trigeminal nerve and aspects of its relation to olfaction. Int. Arch. Occup. Environ. Health 75 (2002) 305-313
25. Hummel T., Barz S., Lötsch J., Roscher S., Kettenmann B., and Kobal G. Loss of olfactory function leads to a decrease of trigeminal sensitivity. Chem. Senses 21 (1996) 75-79
26. Hummel T., Sekinger B., Wolf S., Pauli E., and Kobal G. "Sniffin' Sticks": olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold. Chem. Senses 22 (1997) 39-52
27. Hummel T., Futschik T., Frasnelli J., and Huttenbrink K.B. Effects of olfactory function, age, and gender on trigeminally mediated sensations: a study based on the lateralization of chemosensory stimuli. Toxicol. Lett. 140-141 (2003) 273-280
28. Hummel T., Doty R.L., and Yousem D.M. Functional MRI of intranasal chemosensory trigeminal activation. Chem. Senses 30 Suppl. 1 (2005) i205-i206
29. Hummel T., Beuthien-Baumann B., Heinke M., Oehme L., van den Hoff J., and Gerber J.C. PET-based investigation of cerebral activation following intranasal trigeminal stimulation. Chem. Senses 31 (2006) A60-A61
30. Jantsch H.H., Kemppainen P., Ringler R., Handwerker H.O., and Forster C. Cortical representation of experimental tooth pain in humans. Pain 118 (2005) 390-399
31. Kakigi R., Nakata H., Inui K., Hiroe N., Nagata O., Honda M., Tanaka S., Sadato N., and Kawakami M. Intracelebral pain processing in a Yoga Master who claims not to feel pain during meditation. Eur. J. Pain 9 (2005) 581-589
32. Kobal G. Elektrophysiologische Untersuchungen des menschlichen Geruchssinns (1981), Thieme Verlag, Stuttgart
33. Kobal G., and Hummel C. Cerebral chemosensory evoked potentials elicited by chemical stimulation of the human olfactory and respiratory nasal mucosa. Electroenceph. Clin. Neurophysiol. 71 (1988) 241-250
34. Kobal G., Hummel T., Sekinger B., Barz S., Roscher S., and Wolf S. "Sniffin' sticks": screening of olfactory performance. Rhinology 34 (1996) 222-226
35. Kobal G., Klimek L., Wolfensberger M., Gudziol H., Temmel A., Owen C.M., Seeber H., Pauli E., and Hummel T. Multicenter investigation of 1,036 subjects using a standardized method for the assessment of olfactory function combining tests of odor identification, odor discrimination, and olfactory thresholds. Eur. Arch. Otorhinolaryngol. 257 (2000) 205-211
36. Laska M., Distel H., and Hudson R. Trigeminal perception of odorant quality in congenitally anosmic subjects. Chem. Senses 22 (1997) 447-456
37. Livermore A., Hummel T., and Kobal G. Chemosensory evoked potentials in the investigation of interactions between the olfactory and the somatosensory (trigeminal) systems. Electroenceph. Clin. Neurophysiol. 83 (1992) 201-210
38. Oldfield R.C. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9 (1971) 97-113
39. Penny W.D., Holmes A.P., and Friston K.J. Random effects analysis. In: Frackowiak R.S.J., Frith C., Dolan R., Friston K.J., Price C.J., Zeki S., Ashburner J., and Penny W.D. (Eds). Human Brain Function. 2nd ed. (2003), Academic Press, New York 127-145
40. Peyron R., Laurent B., and Garcia-Larrea L. Functional imaging of brain responses to pain. A review and meta-analysis. Neurophysiol. Clin. 30 (2000) 263-288
41. Price C.J., and Friston K.J. Cognitive conjunction: a new approach to brain activation experiments. Neuroimage 5 (1997) 261-270
42. Ruehle B.S., Handwerker H.O., Lennerz J.K., Ringler R., and Forster C. Brain activation during input from mechanoinsensitive versus polymodal C-nociceptors. J. Neurosci. 26 (2006) 5492-5499
43. Savic I., Gulyas B., and Berglund H. Odorant differentiated pattern of cerebral activation: comparison of acetone and vanillin. Hum. Brain Mapp. 17 (2002) 17-27
44. Stevens J.C., Plantinga A., and Cain W.S. Reduction of odor and nasal pungency associated with aging. Neurobiol. Aging 3 (1982) 125-132
45. Stone H. Effect of ethmoidal nerve stimulation on olfactory bulbar electrical activity. In: Pfaffmann C. (Ed). Olfaction and Taste (1969), Roeckefeller University Press, New York 216-220
46. Walker J.C., Reynolds J.H., Warren D.W., and Sidman J.D. Responses of normal and anosmic subjects to odorants. In: Green B.G., Mason J.R., and Kare M.R. (Eds). Chemical Senses. Irritation Vol. 2 (1990), Marcel Dekker, New York 95-117
47. WMA. World Medical Association: Declaration of Helsinki. Recommendations guiding physicians in biomedical research involving human subjects. J. Med. Assoc. 277 (1997) 925-926
48. Wolfensberger M., Schnieper I., and Welge-Lussen A. Sniffin' Sticks: a new olfactory test battery. Acta Oto-laryngol. 120 (2000) 303-306
49. Youngentob S.L., Hornung D.E., and Mozell M.M. Determination of carbon dioxide detection thresholds in trained rats. Physiol. Behav. 49 (1991) 21-26
50. Yousem D.M., Geckle R.J., Bilker W., McKeown D.A., and Doty R.L. MR evaluation of patients with congenital hyposmia or anosmia. Am. J. Radiol. 166 (1996) 439-443