Familial-genetic and reproductive epidemiology of schizophrenia in rural Ireland: Age at onset, familial morbid risk and parental fertility

Acta Psychiatrica Scandinavica

Volumn 93, Issue 1, 1996, Pages 62-68

  Waddington, J L ^a   Youssef, H A ^b  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^b St Davnet's Hospital   (Ireland)

Author keywords

Age at onset; Epidemiology; Fertility; Gender; Reproduction; Schizophrenia

Indexed keywords

ADULT; ARTICLE; FAMILY; FEMALE; FERTILITY; GENETICS; HUMAN; IRELAND; MAJOR CLINICAL STUDY; MALE; MARRIAGE; ONSET AGE; PRIORITY JOURNAL; RISK FACTOR; SCHIZOPHRENIA;

EID: 0030062845     PISSN: 0001690X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0447.1996.tb10620.x     Document Type: Article

References (58)

1. GOTTESMAN II, SHIELDS J. Schizophrenia: the epigenetic puzzle. New York: Cambridge University Press, 1982.
2. KENDLER KS, DIEHL SR. The genetics of schizophrenia: a current, genetic-epidemiologic perspective. Schiz Bull 1993: 19: 261-285.
3. WADDINGTON JL, WELLER MPI. Schizophrenia: genetic retrenchment and epidemiological renaissance. Arch Gen Psychiatry 1992: 49: 990-994.
4. WADDINGTON JL. Schizophrenia: developmental neuroscience and pathobiology. Lancet 1993: 341: 531-536.
5. MEDNICK SA, MACHON RA, HUTTUNEN M et al. Adult schizophrenia following prenatal exposure to an influenza epidemic. Arch Gen Psychiatry 1988: 45: 189-192.
6. O'CALLAGHAN E, SHAM P, TAKEI N et al. Schizophrenia after prenatal exposure to 1957 A2 influenza epidemic. Lancet 1991: 337: 1248-1250.
7. ADAMS W, KENDELL RE, HARE E et al. Epidemiological evidence that maternal influenza contributes to the aetiology of schizophrenia: an analysis of Scottish, English and Danish data. Br J Psychiatry 1993: 163: 522-534.
8. CROW TJ, DONE DJ. Prenatal exposure to influenza does not cause schizophrenia. Br J Psychiatry 1992: 161: 390-393.
9. SUSSER E, LIN S. Schizophrenia after prenatal exposure to the Dutch hunger winter of 1944-45. Arch Gen Psychiatry 1992: 49: 983-988.
10. TORREY EF, BOWLER A. Geographical distribution of insanity in America: evidence for an urban factor. Schiz Bull 1990: 16: 591-604.
11. LEWIS G, DAVID A, ANDREASSON S et al. Schizophrenia and city life. Lancet 1992: 340: 137-140.
12. SARTORIUS N, JABLENSKY A, KORTEN A et al. Early manifestations and first-contact incidence of schizophrenia in different cultures. Psychol Med 1986: 16: 909-928.
13. DER G, GUPTA S, MURRAY RM. Is schizophrenia disappearing? Lancet 1990: 335: 513-516.
14. EAGLES JM. Is schizophrenia disappearing? Br J Psychiatry 1991: 158: 834-835.
15. KENDELL RE, MALCOLM DE, ADAMS W. The problem of detecting changes in the incidence of schizophrenia. Br J Psychiatry 1993: 162: 212-218.
16. MCGUFFIN P, FARMER A, GOTTESMAN II. Is there really a split in schizophrenia? The genetic evidence. Br J Psychiatry 1987: 150: 581-592.
17. MEEHL PE. Schizotaxia revisited. Arch Gen Psychiatry 1989: 46: 935-944.
18. TSUANG MT, LYONS MJ, FARAONE SV. Heterogeneity of schizophrenia: conceptual models and analytic strategies. Br J Psychiatry 1990: 156: 17-26.
19. YOUSSEF HA, KINSELLA A, WADDINGTON JL. Evidence for geographical variations in the prevalence of schizophrenia in rural Ireland. Arch Gen Psychiatry 1991: 48: 254-258.
20. YOUSSEF HA, KINSELLA A, WADDINGTON JL. Gender specificity of geographical variation in morbid risk for schizophrenia in rural Ireland. Acta Psychiatr Scand 1993: 88: 135-139.
21. WADDINGTON JL, YOUSSEF HA. Evidence for a gender-specific decline in the rate of schizophrenia in rural Ireland over a 50-year period. Br J Psychiatry 1994: 164: 171-176.
22. GOLDSTEIN JM, FARAONE SV, CHEN WJ et al. Sex differences in the familial transmission of schizophrenia. Br J Psychiatry 1990: 156: 819-826.
23. WOLYNIEC PS, PULVER AE, MCGRATH JA et al. Schizophrenia: gender and familial risk. J Psychiat Res 1992: 26: 17-27.
24. KENDLER KS, TSUANG MT, HAYS P. Age at onset in schizophrenia. Arch Gen Psychiatry 1987: 44: 881-890.
25. SHAM PC, JONES P, RUSSELL A et al. Age at onset, sex and familial psychiatric morbidity in schizophrenia. Br J Psychiatry 1994: 165: 466-473.
26. SAUGSTAD LF. Social class, marriage, and fertility in schizophrenia. Schiz Bull 1989: 15: 9-43.
27. AMERICAN PSYCHIATRIC ASSOCIATION. Diagnostic and statistical manual of mental disorders, 3rd edn., revised. Washington, DC: APA, 1987.
28. WADDINGTON JL, YOUSSEF HA. The expression of schizophrenia, affective disorder and vulnerability to tardive dyskinesia in an extensive pedigree. Br J Psychiatry 1988: 153: 376-381.
29. ANDREASEN NC, RICE J, ENDICOTT J et al. The family history approach to diagnosis. Arch Gen Psychiatry 1986: 43: 421-429.
30. BAKER NJ, BERRY L, ADLER LE. Family diagnoses missed on a clinical inpatient service. Am J Psychiatry 1987: 144: 630-632.
31. WADDINGTON JL, YOUSSEF HA, DOLPHIN C et al. Cognitive dysfunction, negative symptoms and tardive dyskinesia in schizophrenia. Arch Gen Psychiatry 1987: 44: 907-912.
32. FEIGHNER JP, ROBINS SE, GUZE SB et al. Diagnostic criteria for use in psychiatric research. Arch Gen Psychiatry 1972: 26: 57-63.
33. COHEN J. A coefficient of agreement for nominal scales. Educ Psychol Meas 1960: 10: 37-46.
34. WEINBERG W. Methoden und Tecknik der Statistik mit besonders Berucksichtigung der Sozialbiologie. In: Gottstein A et al., ed. Handbuch der Sozialen Hygiene und Gesundheitsfursorge. Berlin, 1925: 71-148.
35. SLATER E, COWIE V. The genetics of mental disorders. Oxford: Oxford University Press, 1971.
36. KENDLER KS, MCGUIRE M, GRUENBERG AM et al. The Roscommon family study. I. Methods, diagnosis of probands, and risk of schizophrenia in relatives. Arch Gen Psychiatry 1993: 50: 527-540.
37. BREBOROWICZ G, TRZEBIATOWSKA-TRZECIAK O. A method for testing differences in morbidity risk for affective psychoses. Acta Psychiatr Scand 1976: 54: 353-358.
38. GUTH C, JONES P, MURRAY R. Familial psychiatric illness and obstetric complications in early-onset affective disorder. Br J Psychiatry 1993: 163: 492-498.
39. WADDINGTON JL, YOUSSEF HA, KINSELLA A. Geographical variations in the prevalence of schizophrenia. Arch Gen Psychiatry 1992: 49: 907-908.
40. GEDDES JR, BLACK RJ, WHALLEY LJ et al. Persistence of the decline in the diagnosis of schizophrenia among first admissions to Scottish hospitals from 1969 to 1988. Br J Psychiatry 1993: 163: 620-626.
41. MAIER W, LICHTERMANN D, MINGES J et al. The impact of gender and age at onset on the familial aggregation of schizophrenia. Eur Arch Psychiat Clin Neurosci 1993: 242: 279-285.
42. BELLODI L, BUSSOLENI, SCORZA-SMERALDI R et al. Family study of schizophrenia: exploratory analysis for relevant factors. Schiz Bull 1986: 12: 120-128.
43. SHIMIZU A, KURACHI M, YAMAGUCHI N et al. Morbidity risk of schizophrenia to parents and siblings of schizophrenia patients. Jap J Psychiat Neurol 1987: 41: 65-70.
44. ANGERMEYER MC, KUHN L. Gender differences in age at onset of schizophrenia. Eur Arch Psychiat Neurol Sci 1988: 237: 351-364.
45. LEWIS S. Sex and schizophrenia: vive la difference. Br J Psychiatry 1992: 161: 445-450.
46. HAFNER H, MAURER K, LOFFLER W et al. The influence of age and sex on the onset and early course of schizophrenia. Br J Psychiatry 1993: 162: 80-86.
47. PULVER AE, BROWN CH, WOLYNIEC P et al. Schizophrenia: age at onset, gender and familial risk. Acta Psychiatr Scand 1990: 82: 344-351.
48. GOLDSTEIN JM, FARAONE SV, CHEN WJ et al. Gender and the familial risk for schizophrenia: disentangling confounding factors. Schiz Res 1992: 7: 135-140.
49. LANE A, BYRNE M, MULVANY F et al. Reproductive behaviour in schizophrenia relative to other mental disorders: evidence for increased fertility in men despite decreased marital rate. Acta Psychiatr Scand 1995: 91: 222-228.
50. HUXLEY J, MAYRE E, OSMOND H et al. Schizophrenia as a genetic morphism. Nature 1964: 204: 220-221.
51. GOTTESMAN II, BERTELSEN A. Confirming unexpressed genotypes for schizophrenia. Arch Gen Psychiatry 1989: 46: 867-872.
52. DORFMAN A, SHIELDS G, DELISI LE. DSM-III-R personality disorders in parents of schizophrenic patients. Am J Med Genet (Neuropsychiat Genet) 1993: 48: 60-62.
53. KENDLER KS, MCGUIRE M, GRUENBERG AM et al. The Roscommon family study. III. Schizophrenia-related personality disorders in relatives. Arch Gen Psychiatry 1993: 50: 781-788.
54. PENROSE LS. Survey of cases of mental illness. Eur Arch Psychiat Clin Neurosci 1991: 240: 315-324.
55. DECINA D, MUKHERJEE S, LUCAS L et al. Patterns of illness in parent-child pairs both hospitalized for either schizophrenia or a major mood disorder. Psychiat Res 1991: 39: 81-87.
56. KENDLER KS, MCGUIRE M, GRUENBERG AM et al. The Roscommon family study. IV. Affective illness, anxiety disorders, and alcoholism in relatives. Arch Gen Psychiatry 1993: 50: 952-960.
57. MAIER, LICHTERMANN D, MINGES J et al. Continuity and discontinuity of affective disorders and schizophrenia. Arch Gen Psychiatry 1993: 50: 871-883.
58. MCINNIS MG, MCMAHON FJ, CHASE GA et al. Anticipation in bipolar affective disorder. Am J Hum Genet 1993: 53: 385-390.