Lysosomal responses and metallothionein induction in the blue mussel Mytilus edulis from the south-west coast of Iceland

Environment International

Volumn 33, Issue 3, 2007, Pages 362-369

  Da Ros, L ^a   Moschino, V ^a   Guerzoni, S ^a   Halldorsson H P ^a,b  

^a INSTITUTE OF MARINE SCIENCES   (Italy)

^b UNIVERSITY OF ICELAND   (Iceland)

Author keywords

Biomarkers; Biomonitoring; Iceland; Lysosome; Metallothioneins; Mytilus edulis

Indexed keywords

BIOMARKERS; CRYOSTATS; ENVIRONMENTAL ENGINEERING; IMPURITIES; LIPIDS; ORGANOMETALLICS;

BIOMONITORING; ICELAND; LYSOSOME; METALLOTHIONEINS; MYTILUS EDULIS;

MARINE POLLUTION;

LIPID; LIPOFUSCIN; METALLOTHIONEIN; ORGANOMETALLIC COMPOUND; POLYCYCLIC AROMATIC HYDROCARBON;

BIOACCUMULATION; BIOMARKER; BIOMONITORING; BIVALVE; COASTAL ZONE; INTERTIDAL ENVIRONMENT; MARINE POLLUTION; ORGANOMETALLIC COMPOUND; PAH; POLLUTION EFFECT; SUBARCTIC REGION;

ANIMAL TISSUE; ARTICLE; COASTAL WATERS; CONTAMINATED MUSSEL; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; FROZEN SECTION; HEPATOPANCREAS; ICELAND; IMAGE ANALYSIS; INTERTIDAL ZONE; LYSOSOME; MUSSEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN INDUCTION; QUANTITATIVE ANALYSIS; SEA POLLUTION; SHIPPING;

ARCTIC; HVALFJORDUR; ICELAND; OSAR BAY; REYKJANES PENINSULA; REYKJAVIK;

MYTILUS EDULIS;

EID: 33847257539     PISSN: 01604120     EISSN: 18736750     Source Type: Journal    
DOI: 10.1016/j.envint.2006.11.016     Document Type: Article

References (71)

1. Amiard-Triquet C., Rainglet F., Larroux C., Regoli F., and Hummel H. Metallothioneins in arctic bivalves. Ecotoxicol Environ Saf 41 (1998) 96-102
2. Bancroft J.D. An introduction to histochemical technique (1967), Butterworths, London 268
3. Bayne B.L., Moore M.N., and Koehn R.K. Lysosomes and the response by Mytilus edulis L. to an increase in salinity. Mar Biol Lett 2 (1980) 193-204
4. Bayne B.L., Brown D.A., Burns K., Dixon D.R., Ivanovici A., Livingstone D.R., et al. The effects of stress and pollution on marine animals. Praeger special studies (1985), Praeger Publishers, New York
5. Brunk U.T., and Terman A. Lipofuscin: mechanisms of age-related accumulation and influence on cell function. Free Radic Biol Med 33 (2002) 611-619
6. Cajaraville M.P., Marigomez J.A., and Angulo E. A stereological survey of lysosomal structure alterations in Littorina littorea exposed to 1-naphthol. Comp Biochem Physiol 93C (1989) 231-237
7. Cajaraville M.P., Bebianno M.J., Blasco J., Porte C., Sarasquete C., and Viarengo A. The use of biomarkers to assess the impact of pollution in coastal environments of the Iberian Peninsula: a practical approach. Sci Total Environ 247 (2000) 295-311
8. Camus L., Grøsvick B., Børseth J.F., Jones M.B., and Depledge M.H. Stability of lysosomal and cell membranes in haemocytes of the common mussel (Mytilus edulis): effects of low temperatures. Mar Environ Res 50 (2000) 325-329
9. Camus L., Birkely S.R., Jones M.B., Børseth J.F., Grøsvik B.E., Gulliksen B., et al. Biomarker responses and PAH uptake in Mya truncata following exposure to oil-contaminated sediment in an Arctic fjord (Svalbard). Sci Total Environ 308 (2003) 221-234
10. Cancio I., Ibabe A., and Cajaraville M.P. Seasonal variations of peroxisomal enzyme activities and peroxisomal structure in mussels Mytilus galloprovincialis and its relationship with the lipid content. Comp Biochem Physiol 123C (1999) 135-144
11. Da Ros L., Marin M.G., Nesto N., and Ford S.E. Preliminary results of a field study on some stress-related parameters in Tapes philippinarum naturally infected by the protozoan Perkinsus sp. Mar Environ Res 46 (1998) 249-252
12. Dimitriadis V.K., Domouhtsidou G.P., and Cajaraville M.P. Cytochemical and histochemical aspects of the digestive gland cells of the mussel Mytilus galloprovincialis (L.) in relation to function. J Mol Histol 35 (2004) 501-509
13. Domouhtsidou G.P., and Dimitriadis V.K. Lysosomal and lipid alterations in the digestive gland of mussels, Mytilus galloprovincialis (L.) as biomarkers of environmental stress. Environ Pollut 115 (2001) 123-137
14. Domouhtsidou G.P., Dailianis S., Kaloyianni M., and Dimitriadis V.K. Lysosomal membrane stability and metallothionein content in Mytilus galloprovincialis (L.), as biomarkers: combination with trace metal concentrations. Mar Pollut Bull 48 (2004) 572-586
15. Egilsson D., Ólafsdóttir E.D., Ingvadóttir E., Halldórsdóttir H., Sigur{eth}sson F.H., Jónsson G.S., et al. Mælingar á mengandi efnum á og vi{eth} Ísland. Ni{eth}urstö{eth}ur vöktunarmælinga. Starfshópur um mengunarmælingar, Umhverfisrá{eth}uneyti{eth} (Measurements of contaminants in and near Iceland. Results from monitoring studies. Working group of monitoring, Ministry for the Environment), 1999, Reykjavík (1999) 138 [in Icelandic]
16. Ericson G., Skarphé{eth}insdóttir H., Dalla Zuanna L., and Svavarsson J. DNA adducts as indicators of genotoxic exposure in indigenous and transplanted mussels, Mytilus edulis L. from Icelandic coastal sites. Mutat Res 516 (2002) 91-99
17. Etxeberria M., Cajaraville M.P., and Marigomez I. Changes in digestive cell lysosomal structure in mussels as biomarkers of environmental stress in the Urdaibai Estuary (Biscay Coast, Iberian Peninsula). Mar Pollut Bull 30 (1995) 599-603
18. Følsvik N., Berger J.A., Brevik E.M., and Walday M. Quantification of organotin compounds and determination of imposex in populations of dogwhelks (Nucella lapillus) from Norway. Chemosphere 38 (1999) 681-691
19. Halldórsson H.P., Ericson G., and Svavarsson J. DNA strand breakage in mussels (Mytilus edulis L.) deployed in intertidal and subtidal zones in Reykjavik harbour. Mar Environ Res 58 (2004) 763-767
20. Halldórsson H.P., Svavarsson J., and Granmo Å. The effect of pollution on scope for growth of the mussel (Mytilus edulis L.) in Iceland. Mar Environ Res 59 (2005) 47-64
21. Hamza-Chaffai A., Amiard J.C., Pellerin J., Joux L., and Berthet B. The potential use of metallothionein in the clam Ruditapes decussatus as a biomarker of in situ metal exposure. Comp Biochem Physiol 127C (2000) 185-197
22. Hole L.R., Moore M.N., and Bellamy D. Age-related cellular reactions to copper in the marine mussel Mytilus edulis. Mar Ecol Prog Ser 94 (1993) 175-179
23. Hole L.R., Moore M.N., and Bellamy D. Age-related cellular and physiological reactions to hypoxia and hyperthermia in marine mussels. Mar Ecol Prog Ser 122 (1995) 173-178
24. Holland G. The Arctic ocean - the management of change in the northern seas. Ocean Coast Manag 45 (2002) 841-851
25. Krishnakumar P.K., Casillas E., and Varanasi U. Effect of environmental contaminations on the health of Mytilus edulis from Puget Sound. Washington: I. Cytochemical measures of lysosomal responses in the digestive cells using image analysis. Mar Ecol Prog Ser 106 (1994) 249-261
26. Koukouzika N., and Dimitriadis V.K. Multiple biomarker comparison in Mytilus galloprovincialis from the Greek Coast: lysosomal membrane stability, neutral red retention, micronucleus frequency and stress on stress. Ecotoxicology 14 (2005) 449-463
27. Lam P.K.S., and Gray J.S. The use of biomarkers in environmental monitoring programmes. Mar Pollut Bull 46 (2003) 182-186
28. Leung KM.Y., Dewhurst R.E., Halldórsson H., and Svavarsson J. Metallothioneins and trace metals in the dogwhelk Nucella lapillus (L.) collected from Icelandic coasts. Mar Pollut Bull 51 (2005) 729-737
29. Livingstone D.R., and Pipe R.K. Mussels and environmental contaminants: molecular and cellular aspects. In: Gosling E. (Ed). The mussel mytilus: Ecology, physiology, genetic and culture vol. 425-464 (1992), Elsevier Science Publishers, Amsterdam
30. Lowe D.M. Alterations in the cellular structure of Mytilus edulis resulting from exposure to environmental contaminants under field and experimental conditions. Mar Ecol Prog Ser 46 (1988) 91-100
31. Lowe D.M., Moore M.N., and Clarke K.R. Effects of oil on digestive cells in mussels: quantitative alterations in cellular and lysosomal structure. Aquat Toxicol 1 (1981) 213-226
32. Lowe D.M., Fossato V.U., and Depledge M.H. Contaminant-induced lysosomal membrane damage in blood cells of mussels Mytilus galloprovincialis from the Venice laggon: an in vitro study. Mar Ecol Prog Ser 129 (1995) 189-196
33. Marigomez I., and Baybay-Villacorta L. Pollutant-specific and general lysosomal responses in digestive cells of mussels exposed to model organic chemicals. Aquat Toxicol 64 (2003) 235-257
34. Marigomez I., Gil J.M., and Angulo E. Accumulation of pigment and lipofuscin granules in Littorina littorea exposed to sublethal concentrations of cadmium: a histochemical study. Zool Jb Anat 120 (1990) 127-141
35. Marigomez I., Orbea A., Olabarrieta I., Etxeberria M., and Cajaraville M.P. Structural changes in the digestive lysosomal system of sentinel mussels as biomarkers of environmental stress in Mussel-Watch Programmes. Comp Biochem Physiol 113C (1996) 291-297
36. Marigomez I., Soto M., Cajaraville M.P., Angulo E., and Giamberini L. Cellular and subcellular distribution of metals in molluscs. Microsc Res Tech 56 5 (2002) 358-392
37. Marigomez I., Izagirre U., and Lekube X. Lysosomal enlargement in digestive cells of mussels exposed to cadmium, benzo[a]pyrene and their combination. Comp Biochem Physiol 141C (2005) 188-193
38. Marigomez I., Lekube X., Cajaraville M.P., Domouhtsidou G.P., and Dimitriadis V.K. Comparison of cytochemical procedures to estimate lysosomal biomarkers in mussel digestive cells. Aquat Toxicol 75 (2005) 86-95
39. Moore M.N. Cytochemical demonstration of latency of lysosomal hydrolases in digestive cells of the common mussel, Mytilus edulis, and changes induced by thermal stress. Cell Tissue Res 175 (1976) 279-287
40. Moore M.N. Lysosomal responses to environmental chemicals in some marine invertebrates. In: Giam C.S. (Ed). Pollutants effects on marine organisms (1977), D.C. Health and Co., Lexington 143-154
41. Moore M.N. Cytochemical determination of cellular responses to environmental stressors in marine organisms. Rapp P - v Reun Cons int Explor Mer 179 (1980) 7-15
42. Moore M.N. Cytochemical responses of the lysosomal system and NADPH-ferrihemoprotein reductase in molluscan digestive cells to environmental and experimental exposure to xenobiotics. Mar Ecol Prog Ser 46 (1988) 81-89
43. Moore MN. Reactions of molluscan lysosomes as biomarkers of pollutant-induced cell injury. In: Renzoni A, Mattei N, Fosssi MC, editors. Contaminants in the environment. A multidisciplinary assessment of risks to man and other organisms. CRC Press, Lewis Publishers, Boca Raton 1994, 111-123.
44. Moore M.N., Koehn R.K., and Bayne B.L. Leucine aminopeptidase (Aminopeptidase I) N-acetyl-h-hexosaminidase and lysosomes in the mussel, Mytilus edulis L, in response to salinity changes. J Exp Zool 214 (1980) 239-249
45. Moore M.N., Depledge M.H., Readman J.W., and Leonard D.R.P. An integrated biomarker-based strategy for ecotoxicological evaluation of risk in environmental management. Mutat Res 552 (2004) 247-268
46. Moore M.N., Allen I.J., and McVeigh A. Environmental prognostics: an integrated model supporting lysosomal stress responses as predictive biomarkers of animal health status. Mar Environ Res 61 (2006) 278-304
47. Mourgaud Y., Martinez E., Geffard A., Andral B., Stanisiere J.Y., and Amiard J. Metallothionein concentration in the mussel Mytilus galloprovincialis as a biomarker of response to metal contamination: validation in the field. Biomarkers 7 (2002) 479-490
48. Muir D., Savinova T., Savinov V., Alexeeva L., Potelov V., and Svetochev V. Bioaccumulation of PCBs and chlorinated pesticides in seals, fishes and invertebrates from the White Sea, Russia. Sci Total Environ 306 (2003) 111-131
49. Owen G. Lysosomes, peroxisomes and bivalves. Sci Prog 60 (1970) 299-318
50. Pearse A.G.E. Histochemistry, theoretical and applied vol. 2 (1972), Churchill-Livingstone, London
51. Petrović S., Ozretic B., Krajnovic-Ozretić M., and Bobinac D. Lysosomal membrane stability and metallothioneins in digestive gland of mussels (Mytilus galloprovincialis Lam.) as biomarkers in a field study. Mar Pollut Bull 42 (2001) 1373-1378
52. Petrović S., Semencić L., Ozretić B., and Ozretić M. Seasonal variations of physiological and cellular biomarkers and their use in the biomonitoring of north-adriatic coastal waters (Croatia). Mar Pollut Bull 49 (2004) 713-720
53. Raspor B., Dragun Z., Erk M., Ivankovic D., and Pavicic J. Is the digestive gland of Mytilus galloprovincialis a tissue of choice for estimating cadmium exposure by means of metallothioneins?. Sci Total Environ 333 (2004) 99-108
54. Regoli F. Lysosomal responses as a sensitive stress index in biomonitoring heavy metal pollution. Mar Ecol Prog Ser 84 (1992) 63-69
55. Regoli F., Hummel H., Amiard-Triquet C., Larroux C., and Sukhotin A. Trace metals and variations of antioxidant enzymes in arctic bivalve populations. Arch Environ Contam Toxicol 35 (1998) 594-601
56. Ringwood A.H., Conners D., and Hoguet J. Effects of natural and anthropogenic stressors on lysosomal destabilization in oysters Crassostrea virginica. Mar Ecol Prog Ser 166 (1998) 163-171
57. Seed R. Ecology. In: Bayne B.L. (Ed). Marine Mussels: their ecology and physiology (1976), Cambridge University Press, Cambridge 13-65
58. Sokal R.R., and Rohlf F.J. Biometry (2000), W.H. Freeman and Company, New York
59. Skarphé{eth}insdóttir H., Ólafsdóttir K., Svavarsson J., and Jóhannesson T. Seasonal fluctuations of tributyltin (TBT) and dibutyltin (DBT) in the dogwhelk, Nucella lapillus (L.), and the blue mussel, Mytilus edulis L., in Iceland waters. Mar Pollut Bull 32 4 (1996) 358-361
60. Stephensen E., Svavarsson J., Sturve J., Ericson G., Adolfsson-Erici M., and Förlin L. Biochemical indicators of pollution exposure in shorthorn sculpin (Myoxocephalus scorpius), caught in four harbours on the southwest coast of Iceland. Aquat Toxicol 48 (2000) 431-442
61. Strand J., and Asmund G. Tributyltin accumulation and effects in marine molluscs from West Greenland. Environ Pollut 123 (2003) 31-37
62. Terman A., and Brunk U.T. Lipofuscin. Int J Biochem Cell Biol 36 (2004) 1400-1404
63. Thorarinsdóttir G.G. Gonad development, larval settlement and growth of Mytilus edulis L. in a suspended population in Hvalfjördur, south-west Iceland. Aquac Res 27 (1996) 57-65
64. Thorarinsdóttir G.G., and Gunnarsson K. Reproductive cycle of Mytilus edulis L. on the west and east coasts of Iceland. Polar Res 22 (2003) 217-223
65. UNEP. Manual on the biomarkers recommended for the MED POL biomonitoring programme. UNEP (OCA) MED 132/3, Athens, Greece (1999)
66. Valette-Silver N., Hameedi M.J., Efurd D.W., and Robertson A. Status of the contamination in sediments and biota from the western Beaufort Sea (Alaska). Mar Pollut Bull 38 8 (1999) 702-722
67. Vetter W., Hummert K., Luckas B., and Skírnisson K. Organochlorine residues in two seal species from Western Iceland. Sci Total Environ 170 (1995) 159-164
68. Viarengo A., and Nott J. Mechanisms of heavy metal cation homeostasis in marine invertebrates. Comp Biochem Physiol 104C (1993) 355-372
69. Viarengo A., Pertica M., Canesi L., Mazzucotelli A., Orunesu M., and Bouquegneau J.M. Purification and biochemical characterisation of a lysosomal copper-rich thionein-like protein involved in metal detoxification in the digestive gland of mussels. Comp Biochem Physiol 93C (1989) 389-395
70. Viarengo A., Ponzano E., Dondero F., and Fabbri R. A simple spectrophotometric method for metallothionein evaluation in marine organisms: an application to Mediterranean and Antarctic molluscs. Mar Environ Res 44 1 (1997) 69-84
71. Yngvadóttir E., Halldórsdóttir H., Ragnarsdóttir {Thorn}., and Uusinoka T. Monitoring of the marine biosphere around Iceland 2003 and 2004. Icelandic Fisheries Laboratories report 13-05, project no. 1610 (2005), Ministry for the Environment. http://www.rf.is/media/utgafa//Skyrsla13-05.pdf http://www.rf.is/media/utgafa//Skyrsla13-05.pdf