Oral treatment with probucol in a pharmacological dose has no beneficial effects on mortality in chronic ischemic heart failure after large myocardial infarction in rats

European Journal of Pharmacology

Volumn 558, Issue 1-3, 2007, Pages 119-127

  Betge, Stefan ^a   Lutz, Katharina ^a   Roskos, Martin ^a   Figulla, Hans Reiner ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Antioxidants; Cardiac remodeling; Experimental myocardial infarction; Heart failure; Probucol

Indexed keywords

ANTIOXIDANT; COLLAGEN; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; PLACEBO; PROBUCOL; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FIBROSING ALVEOLITIS; HEART FAILURE; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE; HEART MUSCLE ISCHEMIA; KAPLAN MEIER METHOD; LEWIS RAT; MALE; MORTALITY; NONHUMAN; PRIORITY JOURNAL; RANDOMIZATION; RAT; SURVIVAL RATE; SURVIVAL TIME; TREATMENT OUTCOME; VASODILATATION;

ADMINISTRATION, ORAL; ANIMALS; ANTIOXIDANTS; CHRONIC DISEASE; COLLAGEN; HEART FAILURE, CONGESTIVE; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCARDIUM; PROBUCOL; RATS; RATS, INBRED LEW; SURVIVAL RATE; VENTRICULAR REMODELING;

EID: 33847250381     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.11.049     Document Type: Article

References (30)

1. Bax J.J., Schinkel A.F., Boersma E., Elhendy A., Rizzello V., Maat A., Roelandt J.R., van der Wall E.E., and Poldermans D. Extensive left ventricular remodeling does not allow viable myocardium to improve in left ventricular ejection fraction after revascularization and is associated with worse long-term prognosis. Circulation 110 (2004) II18-II22
2. Belch J.J., Bridges A.B., Scott N., and Chopra M. Oxygen free radicals and congestive heart failure. Br. Heart J. 65 (1991) 245-248
3. Carluccio E., Biagioli P., Alunni G., Murrone A., Giombolini C., Ragni T., Marino P.N., Reboldi G., and Ambrosio G. Patients with hibernating myocardium show altered left ventricular volumes and shape, which revert after revascularization: evidence that dyssynergy might directly induce cardiac remodeling. J. Am. Coll. Cardiol. 47 (2006) 969-977
4. Djahansouzi S., Braesen J.H., Koenig K., Beisiegel U., and Kontush A. The effect of pharmacological doses of different antioxidants on oxidation parameters and atherogenesis in hyperlipidaemic rabbits. Atherosclerosis 154 (2001) 387-398
5. Finkel T. Oxygen radicals and signaling. Curr. Opin. Cell. Biol. 10 (1998) 248-253
6. Fletcher P.J., Pfeffer J.M., Pfeffer M.A., and Braunwald E. Left ventricular diastolic pressure-volume relations in rats with healed myocardial infarction. Effects on systolic function. Circ. Res. 49 (1981) 618-626
7. Fridovich I. Superoxide dismutases. Annu. Rev. Biochem. 44 (1975) 147-159
8. Hill M.F., and Singal P.K. Right and left myocardial antioxidant responses during heart failure subsequent to myocardial infarction. Circulation 96 (1997) 2414-2420
9. Hoshida S., Yamashita N., Igarashi J., Aoki K., Kuzuya T., and Hori M. Long-term probucol treatment reverses the severity of myocardial injury in Watanabe heritable hyperlipidemic rabbits. Arterioscler. Thromb. Vasc. Biol. 17 (1997) 2801-2807
10. Hu K., Gaudron P., and Ertl G. Long-term effects of beta-adrenergic blocking agent treatment on hemodynamic function and left ventricular remodeling in rats with experimental myocardial infarction: importance of timing of treatment and infarct size. J. Am. Coll. Cardiol. 31 (1998) 692-700
11. Ikeuchi M., Tsutsui H., Shiomi T., Matsusaka H., Matsushima S., Wen J., Kubota T., and Takeshita A. Inhibition of TGF-beta signaling exacerbates early cardiac dysfunction but prevents late remodeling after infarction. Cardiovasc. Res. 64 (2004) 526-535
12. Kaul N., Siveski-Iliskovic N., Hill M., Khaper N., Seneviratne C., and Singal P.K. Probucol treatment reverses antioxidant and functional deficit in diabetic cardiomyopathy. Mol. Cell. Biochem. 160-161 (1996) 283-288
13. Li W.G., Zaheer A., Coppey L., and Oskarsson H.J. Activation of JNK in the remote myocardium after large myocardial infarction in rats. Biochem. Biophys. Res. Commun. 246 (1998) 816-820
14. Mansuy P., Mougenot N., Ramirez-Gil J.F., Bonnefont-Rousselot D., Raillecove F., Komajda M., and Lechat P. Effects of prolonged propranolol treatment on left ventricular remodeling and oxidative stress after myocardial infarction in rats. J. Cardiovasc. Pharmacol. 35 (2000) 806-813
15. Miyashita F., Kawaguchi A., Sugimoto K., Kitoh Y., Tsutsumi H., and Fujimura A. Failure of probucol to prolong survival in salt-loaded stroke-prone spontaneously hypertensive rats. Hypertens. Res. 23 (2000) 497-501
16. Nakamura R., Egashira K., Machida Y., Hayashidani S., Takeya M., Utsumi H., Tsutsui H., and Takeshita A. Probucol attenuates left ventricular dysfunction and remodeling in tachycardia-induced heart failure: roles of oxidative stress and inflammation. Circulation 106 (2002) 362-367
17. Oskarsson H.J., Coppey L., Weiss R.M., and Li W.G. Antioxidants attenuate myocyte apoptosis in the remote non-infarcted myocardium following large myocardial infarction. Cardiovasc. Res. 45 (2000) 679-687
18. Paglia D.E., and Valentine W.N. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med. 70 (1967) 158-169
19. Rabkin D.G., Weinberg A.D., and Spotnitz H.M. Optimizing probucol administration to preserve left ventricular compliance after reperfusion injury in the heterotopic rat heart isograft. J. Heart Lung Transplant. 22 (2003) 959-966
20. Richard M.J., Portal B., Meo J., Coudray C., Hadjian A., and Favier A. Malondialdehyde kit evaluated for determining plasma and lipoprotein fractions that react with thiobarbituric acid. Clin. Chem. 38 (1992) 704-709
21. Selye H., Bajusz E., Grasso S., and Mendell P. Simple techniques for the surgical occlusion of coronary vessels in the rat. Angiology 11 (1960) 398-407
22. Senior R., Lahiri A., and Kaul S. Effect of revascularization on left ventricular remodeling in patients with heart failure from severe chronic ischemic left ventricular dysfunction. Am. J. Cardiol. 88 (2001) 624-629
23. Sia Y.T., Lapointe N., Parker T.G., Tsoporis J.N., Deschepper C.F., Calderone A., Pourdjabbar A., Jasmin J.F., Sarrazin J.F., Liu P., Adam A., Butany J., and Rouleau J.L. Beneficial effects of long-term use of the antioxidant probucol in heart failure in the rat. Circulation 105 (2002) 2549-2555
24. Sia Y.T., Parker T.G., Liu P., Tsoporis J.N., Adam A., and Rouleau J.L. Improved post-myocardial infarction survival with probucol in rats: effects on left ventricular function, morphology, cardiac oxidative stress and cytokine expression. J. Am. Coll. Cardiol. 39 (2002) 148-156
25. Siveski-Iliskovic N., Kaul N., and Singal P.K. Probucol promotes endogenous antioxidants and provides protection against adriamycin-induced cardiomyopathy in rats. Circulation 89 (1994) 2829-2835
26. Spinale F.G., Escobar G.P., Hendrick J.W., Clark L.L., Camens S.S., Mingoia J.P., Squires C.G., Stroud R.E., and Ikonomidis J.S. Chronic matrix metalloproteinase inhibition following myocardial infarction in mice: differential effects on short and long-term survival. J. Pharmacol. Exp. Ther. 318 (2006) 966-973
27. Tagawa T., Urabe Y., Kimura Y., Suzuki S., Ono H., and Takeda K. Long-term treatment with probucol improves endothelial function in patients with coronary artery disease. Hypertens. Res. 27 (2004) 311-318
28. Tardif J.C., Cote G., Lesperance J., Bourassa M., Lambert J., Doucet S., Bilodeau L., Nattel S., and de Guise P. Probucol and multivitamins in the prevention of restenosis after coronary angioplasty. Multivitamins and Probucol Study Group. N. Engl. J. Med. 337 (1997) 365-372
29. von Harsdorf R., Li P.F., and Dietz R. Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis. Circulation 99 (1999) 2934-2941
30. Yagi K. A simple fluorometric assay for lipoperoxide in blood plasma. Biochem. Med. 15 (1976) 212-216