Anticlastogenic effect of redistilled cow's urine distillate in human peripheral lymphocytes challenged with manganese dioxide and hexavalent chromium

Biomedical and Environmental Sciences

Volumn 19, Issue 6, 2006, Pages 487-494

  Dutta, Dipanwita ^a   Devi, S Saravana ^a   Krishnamurthi, K ^a   Chakrabarti, T ^a  

^a NATIONAL ENVIRONMENTAL ENGINEERING RESEARCH INSTITUTE   (India)

Author keywords

Chromosomal aberration; Clastogenicity; DNA strand break; Hexavalent chromium and manganese dioxide; Micronuclei; Redistilled cow's urine distillate (RCUD)

Indexed keywords

ANTIMUTAGENIC AGENT; ANTIOXIDANT; CHROMIUM; CHROMIUM HEXAVALENT ION; MANGANESE DERIVATIVE; MANGANESE DIOXIDE; MUTAGENIC AGENT; OXIDE; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; CATTLE; CELL CULTURE; CHEMISTRY; DNA DAMAGE; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; LYMPHOCYTE; MUTAGEN TESTING; PH; URINE;

ANIMALS; ANTIMUTAGENIC AGENTS; ANTIOXIDANTS; CATTLE; CELLS, CULTURED; CHROMIUM; DNA DAMAGE; HUMANS; HYDROGEN-ION CONCENTRATION; LYMPHOCYTES; MANGANESE COMPOUNDS; MUTAGENICITY TESTS; MUTAGENS; OXIDES; URINE;

EID: 33847244990     PISSN: 08953988     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Chauhan R S (2004). Panchagavya Therapy (Cow pathy). Current status and future directions. The Indian Cow 1(1), 3-7.
2. Dharma K, Rathore R, Chauhan R S, et al. (2005). Panchagavya (Cow pathy): An Overview. International Journal of Cow Science 1(2), 26-29.
3. The Telegraph London, 02/09/2001 A gift from the gods: bottled cow's urine By Julian West in New Delhi (Filed: 02/09/2001).
4. Rohit B K, Pendkar M R, Apte B K (2003). Analytical study of cow urine and its possible role in therapeutics. In National conference on Panchagavya Ayurved Evum Kamdhenu Krishi Tantra (S. Mansinhka, Ed) pp. 24-28, Govygyan Anusandhan Kendra, India.
5. Krishnamurthi K, Dutta D, Sivanesan S D, et al. (2004). Protective effect of distillate and redistillate of cow's urine in human polymorphonuclear leukocytes challanged with established genotoxic chemicals. Biomedical and Environmental Science 17, 247-256.
6. Shi X, Dalal N S (1989). Chromium (V) and hydroxyl radical formation during the glutathione reductase-catalyzed reduction of chromium VI. Biochem Biophys Res Commun 163, 627-634
7. Berlett B S, Chock P B, Vim M B, et al. (1990). Manganese (II) catalyzes the bicarbonate - dependent oxidation of amino acids by hydrogen peroxide and amino acid facilitated dismutation of hydrogen penoxide. Proc Natl Acad Sci USA 87, 389-394.
8. Birnboim H C, Jevcak J J (1981). Fluorimetric method for rapid detection of DNA strand breaks in human white blood cells produced by low doses of radiation. Cancer Research 41, 1889-1892.
9. Krishnamurthi K, Saravana Devi S, Chakrabarti T (2003). Genotoxic effects of PAH containing sludge extracts in Chinese hamster ovary cell cultures. Biomedical and Environmental Sciences 16, 68-82.
10. Api A M, San R H C (1999). Genotoxicity tests with 6-acetyl-1,1,2,4,4,7- hexamethylcyclopenta-y-2-benzopyran. Mutation Research 446, 67-81.
11. Ozkul Y, Silici S, Eroglu E (2005). The anticarcinogenic effect of propolis in human lymphocytes culture. Phytomedicine 12, 742-747.
12. Stella M A, Montaldi R, Rossi G, et al. (1982). Clastogenic effects of chromium on human lymphocytes in vitro and in vivo. Mutation Research 101, 151-164.
13. Tsapakos M J, Wetterhahn K E (1983). The interaction of chromium with nucleic acids. Chem Biol Interact 46, 265-277.
14. Hneihen A S, Standeven A M, Wetterhahn K E (1993). Differential binding of chromium (VI) and chromium (III) complexes to salmon sperm nuclei and nuclear DNA isolated from thymus DNA. Carcinogenesis 14, 1795-1803.
15. Kadiska M B, Xiang Q H, Mason R P (1994). In vivo free radical generation by chromium (VI): an electron spin resonance spin-trapping investigation. Chem Res Toxicol 7, 800-805.
16. Shi X L, Datal N S (1992). The role of Superoxide radical in chromium (VI)-generated hydroxyl radical: the Cr (VI Haber-Weiss Cycle. Arch Biochem Biophys 292, 323-327.
17. Kasai H, Grain P F, Kuchino Y, Nishimura S, et al. (1986). Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair. Carcinogenesis 7, 1849-1851.
18. Zhitkovich-Voitkun V, Costa M (1995). Glutathione and free amino acids form stable complexes with DNA following exposure of intact mammalian cells to chromate. Carcinogenesis 16, 907-913.
19. Zhitkovich-Voitkun V, Costa M (1996). Formation of the amino acid-DNA complexes by hexavalent and trivalent chromium in vitro: importance of trivalent chromium and the phosphate group. Biochemistry 35, 7275-7282.
20. Lirvall M, Ljungqvist-Hoddelius P, Wasteson A, et al. (1996). UVB radiation affects the mobility of epidermal growth factor receptors in human keratinocytes and fibroblasts. Biosci Rep 16, 227-238.