Metabolism of a 14C/3H-labeled GABAA receptor partial agonist in rat, dog and human liver microsomes: Evaluation of a dual-radiolabel strategy

Journal of Pharmaceutical and Biomedical Analysis

Volumn 43, Issue 4, 2007, Pages 1195-1205

  Shaffer, Christopher L ^a   Langer, Connie S ^a  

^a PFIZER INC   (United States)

Author keywords

Dual radiolabel compounds; In vitro drug metabolism; Metabolite structure elucidation

Indexed keywords

2 [[2 (3 FLUOROPYRID 2 YL) 1H IMIDAZOL 1 YL]METHYL] 1 PROPYL 5 CYANO 1H BENZIMIDAZOLE; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; CARBON 14; DRUG METABOLITE; PARTIAL AGONIST; RADIOISOTOPE; TRITIUM; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; CARBON; DIAGNOSTIC AGENT;

ANALYTIC METHOD; ANIMAL TISSUE; ARTICLE; DEALKYLATION; DOG; DRUG METABOLISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG TRANSFORMATION; EVALUATION; FEASIBILITY STUDY; HUMAN; HUMAN TISSUE; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; LIQUID SCINTILLATION COUNTING; LIVER MICROSOME; MALE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RAT; ANIMAL; BIOTRANSFORMATION; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; DRUG POTENTIATION; GENETICS; IN VITRO STUDY; KINETICS; METABOLISM; SCINTILLATION COUNTING; SPRAGUE DAWLEY RAT; TIME;

ANIMALS; BIOTRANSFORMATION; CARBON RADIOISOTOPES; CHROMATOGRAPHY, LIQUID; DOGS; EVALUATION STUDIES; GABA AGONISTS; HUMANS; KINETICS; MALE; MASS SPECTROMETRY; MICROSOMES, LIVER; MOLECULAR STRUCTURE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; SCINTILLATION COUNTING; TIME FACTORS; TRITIUM;

EID: 33847171108     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2006.11.022     Document Type: Article

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