The effects of 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) on food intake in non-deprived C57BL6 mice

European Journal of Pharmacology

Volumn 559, Issue 2-3, 2007, Pages 184-188

  Ebenezer, Ivor S ^a   Surujbally, Ashya ^a  

^a UNIVERSITY OF PORTSMOUTH   (United Kingdom)

Author keywords

(Mouse); 5 HT1A receptors; 8 OH DPAT; Food intake; WAY100635

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN 1A AGONIST; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG RECEPTOR BINDING; FOOD INTAKE; HYPERPHAGIA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; HYPERPHAGIA; INJECTIONS, SUBCUTANEOUS; MALE; MICE; MICE, INBRED C57BL; PIPERAZINES; PYRIDINES; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SPECIES SPECIFICITY; TIME FACTORS;

EID: 33847150468     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.01.010     Document Type: Article

References (27)

1. 1A receptors. Eur. J. Pharmacol. 408 (2000) 273-276
2. 1A antagonists MM-77 and WAY 100635 on the mouse isolated vasa deferentia. Autonom. Autocoid Pharmacol. 25 (2005) 121-127
3. Bendotti C., and Samanin R. R. 8-Hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) elicits eating in free feeding rats by acting on central serotonin neurons. Eur. J. Pharmacol. 121 (1986) 147-150
4. Blundell J.E. Is there a role for serotonin (5-hydroxytryptamine) in feeding?. Int. J. Obes. 1 (1977) 14-42
5. Blundell J.E. Serotonin and appetite. Neuropharmacology 23 (1984) 1537-1551
6. 1A receptor immunoreactivity in hypothalamic neurons involved in body weight control. NeuroReport 13 (2002) 945-951
7. Dourish C.T., Hutson P.H., and Curzon G. Characteristics of feeding induced by the serotonin agonist 2-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT). Brain Res. Bull. 15 (1985) 377-384
8. 1A agonist 8-OH-DPAT increases consumption of palatable we mash and liquid diets in the rat. Psychopharmacology (Berl.) 94 (1988) 58-63
9. Ebenezer I.S. The effects of intracerebroventricular administration of baclofen on food intake in rats. NeuroReport 1 (1990) 73-76
10. Ebenezer I.S. Effects of the 5HT1A agonist, 8-OH-DPAT on operant food intake in non-deprived rats. NeuroReport 3 (1992) 62-64
11. Ebenezer I.S. Effects of gepirone and buspirone on operant food intake in non-deprived rats. Br. J. Pharmacol. 110 (1993) 98P
12. 1A agonist gepirone on food intake in rats may depend on their motivation to eat. Methods Find. Exp. Clin. Pharmacol. 25 (2003) 727-731
13. 1A receptors. Physiol. Behav. 73 (2001) 223-227
14. Fletcher P.J., and Davis M. The involvement of 5-hydroxytryptaminergic and dopaminergic mechanisms in the eating induced by buspirone, gepirone and ipsapirone. Br. J. Pharmacol. 99 (1990) 519-525
15. 1A receptor antagonist. Behav. Brain Res. 73 (1996) 337-353
16. Gilbert F., and Dourish C.T. Effects of the novel anxiolytics gepirone, buspirone and ipsapirone on free feeding and on feeding induced by 8-OH-DPAT. Psychopharmacology (Berl.) 93 (1987) 349-352
17. 1A receptor agonist, 8-OH-DPAT, preferentially activates cell body 5HT autoreceptors in rats brain in vivo. Naunyn-Schmiedeberg's. Arch. Pharmacol. 338 (1988) 463-471
18. Hoyer D., Hannon J.P., and Martin G.R. Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol. Biochem. Behav. 71 (2002) 533-554
19. 1A receptor agonist 8-OH-DPAT on food and water intake in chickens. Physiol. Behav. 75 (2002) 271-275
20. 1A autoreceptor. J. Neurosci. Methods 34 (1990) 83-90
21. Shepherd J.K., and Rogers R.J. 8-OH-DPAT specifically enhances feeding behaviour in mice: evidence from behavioural competition. Psychopharmacology (Berl.) 101 (1990) 408-413
22. 1B agonists. Synapse 1 (1987) 3-9
23. Simansky K.J. Serotonergic control of the organization of feeding and satiety. Behav. Brain Res. 73 (1996) 37-42
24. Swiergiel A.H., and Dunn A.J. Lack of evidence for a role of serotonin in interleukin-1-induced hypophagia. Pharmacol. Biochem. Behav. 65 (2000) 531-537
25. Tite R.M., and Ebenezer I.S. The effects of chronic administration of fluoxetine on 8-OH-DPAT-induce hypophagia in rats. Proc. Br. Pharmacol. Soc. (2004). http://www.pa2online.org//Vol2Issue1abst014P (at http://www.pa2online.org//Vol2Issue1abst014P)
26. Tricklebank M.D., Forler C., and Fozard J.R. The involvement of subtypes of the 5-HT1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-propylamino)tetralin in the rats. Eur. J. Pharmacol. 105 (1984) 271-282
27. Winer B.J. Statistical Principles in Experimental Design (1971), Mc Graw-Hill, New York